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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a4lRRCCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a4lRRCCyclin-dependent kinase 22.7.11.221.000
3lfnA27Cyclin-dependent kinase 22.7.11.220.603
3lfqA28Cyclin-dependent kinase 22.7.11.220.587
3r83Z14Cyclin-dependent kinase 22.7.11.220.586
3r7yZ04Cyclin-dependent kinase 22.7.11.220.568
1oitHDTCyclin-dependent kinase 22.7.11.220.556
2c6o4SPCyclin-dependent kinase 22.7.11.220.554
4ek816KCyclin-dependent kinase 22.7.11.220.546
1w8cN69Cyclin-dependent kinase 22.7.11.220.545
2a0cCK9Cyclin-dependent kinase 22.7.11.220.544
3rpo24ZCyclin-dependent kinase 22.7.11.220.543
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.542
3qzhX69Cyclin-dependent kinase 22.7.11.220.540
2w05FRTCyclin-dependent kinase 22.7.11.220.538
2r3lSCWCyclin-dependent kinase 22.7.11.220.533
1ke7LS3Cyclin-dependent kinase 22.7.11.220.532
3le62BZCyclin-dependent kinase 22.7.11.220.528
2w06FRVCyclin-dependent kinase 22.7.11.220.525
2xmyCDKCyclin-dependent kinase 22.7.11.220.524
1h0w207Cyclin-dependent kinase 22.7.11.220.523
2r64740Cyclin-dependent kinase 22.7.11.220.520
3rm719ZCyclin-dependent kinase 22.7.11.220.519
1y91CT9Cyclin-dependent kinase 22.7.11.220.518
3s2pPMUCyclin-dependent kinase 22.7.11.220.518
2b52D42Cyclin-dependent kinase 22.7.11.220.516
2exmZIPCyclin-dependent kinase 22.7.11.220.516
3r8vZ62Cyclin-dependent kinase 22.7.11.220.516
3r1yX76Cyclin-dependent kinase 22.7.11.220.515
3sqq99ZCyclin-dependent kinase 22.7.11.220.515
1h1s4SPCyclin-dependent kinase 22.7.11.220.514
3ddqRRCCyclin-dependent kinase 22.7.11.220.514
3r7vZ02Cyclin-dependent kinase 22.7.11.220.514
3rahO1ZCyclin-dependent kinase 22.7.11.220.514
1oirHDYCyclin-dependent kinase 22.7.11.220.513
3qqlX03Cyclin-dependent kinase 22.7.11.220.512
3qxoX65Cyclin-dependent kinase 22.7.11.220.512
1b38ATPCyclin-dependent kinase 22.7.11.220.511
1pxmCK5Cyclin-dependent kinase 22.7.11.220.511
2r3iSCFCyclin-dependent kinase 22.7.11.220.511
3s1h56ZCyclin-dependent kinase 22.7.11.220.511
3rni21ZCyclin-dependent kinase 22.7.11.220.510
1h1r6CPCyclin-dependent kinase 22.7.11.220.509
2r3gSC9Cyclin-dependent kinase 22.7.11.220.508
1e1xNW1Cyclin-dependent kinase 22.7.11.220.507
4lyn1YGCyclin-dependent kinase 22.7.11.220.507
1ke6LS2Cyclin-dependent kinase 22.7.11.220.506
2c5yMTWCyclin-dependent kinase 22.7.11.220.506
1oguST8Cyclin-dependent kinase 22.7.11.220.505
3r28XA0Cyclin-dependent kinase 22.7.11.220.505
4bcpT3CCyclin-dependent kinase 22.7.11.220.505
3qwjX6ACyclin-dependent kinase 22.7.11.220.504
3r1sX73Cyclin-dependent kinase 22.7.11.220.504
3r7uX96Cyclin-dependent kinase 22.7.11.220.504
1w0xOLOCyclin-dependent kinase 22.7.11.220.503
3r7iX9ICyclin-dependent kinase 22.7.11.220.503
1di8DTQCyclin-dependent kinase 22.7.11.220.502
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.502
2w1hL0FCyclin-dependent kinase 22.7.11.220.502
3r73X87Cyclin-dependent kinase 22.7.11.220.501
1pyePM1Cyclin-dependent kinase 22.7.11.220.500
1h0vUN4Cyclin-dependent kinase 22.7.11.220.499
4eor4SPCyclin-dependent kinase 22.7.11.220.499
1gih1PUCyclin-dependent kinase 22.7.11.220.498
3r6xX84Cyclin-dependent kinase 22.7.11.220.498
3rm618ZCyclin-dependent kinase 22.7.11.220.498
3ezrEZRCyclin-dependent kinase 22.7.11.220.497
1hckATPCyclin-dependent kinase 22.7.11.220.496
2iw94SPCyclin-dependent kinase 22.7.11.220.495
3rk909ZCyclin-dependent kinase 22.7.11.220.495
4acm7YGCyclin-dependent kinase 22.7.11.220.495
4fkq42KCyclin-dependent kinase 22.7.11.220.495
3ddpRC8Cyclin-dependent kinase 22.7.11.220.494
2uznC96Cyclin-dependent kinase 22.7.11.220.492
1b39ATPCyclin-dependent kinase 22.7.11.220.491
1unlRRCCyclin-dependent-like kinase 52.7.11.10.491
2vtsLZCCyclin-dependent kinase 22.7.11.220.491
4kd11QKCyclin-dependent kinase 22.7.11.220.491
2b55D31Cyclin-dependent kinase 22.7.11.220.490
3lfsA07Cyclin-dependent kinase 22.7.11.220.490
1v1k3FPCyclin-dependent kinase 22.7.11.220.488
2uzoC62Cyclin-dependent kinase 22.7.11.220.488
3qqhX0ACyclin-dependent kinase 22.7.11.220.488
3r71X86Cyclin-dependent kinase 22.7.11.220.488
3r8lZ30Cyclin-dependent kinase 22.7.11.220.488
3ig7EFPCyclin-dependent kinase 22.7.11.220.487
3iggEFQCyclin-dependent kinase 22.7.11.220.487
2b53D23Cyclin-dependent kinase 22.7.11.220.486
2iw84SPCyclin-dependent kinase 22.7.11.220.485
2r3p3SCCyclin-dependent kinase 22.7.11.220.485
3r7eX88Cyclin-dependent kinase 22.7.11.220.485
2r3jSCJCyclin-dependent kinase 22.7.11.220.484
3wblPDYCyclin-dependent kinase 22.7.11.220.484
1aq1STUCyclin-dependent kinase 22.7.11.220.483
2r3o2SCCyclin-dependent kinase 22.7.11.220.483
3qx2X63Cyclin-dependent kinase 22.7.11.220.483
1oi9N20Cyclin-dependent kinase 22.7.11.220.482
1pxlCK4Cyclin-dependent kinase 22.7.11.220.482
2b54D05Cyclin-dependent kinase 22.7.11.220.482
2r3kSCQCyclin-dependent kinase 22.7.11.220.482
3rk708ZCyclin-dependent kinase 22.7.11.220.481
3s0o50ZCyclin-dependent kinase 22.7.11.220.481
2c6lDT4Cyclin-dependent kinase 22.7.11.220.480
3qqfX07Cyclin-dependent kinase 22.7.11.220.480
3qzgX67Cyclin-dependent kinase 22.7.11.220.480
3rjc06ZCyclin-dependent kinase 22.7.11.220.480
1pxoCK7Cyclin-dependent kinase 22.7.11.220.478
3qu0X40Cyclin-dependent kinase 22.7.11.220.478
3r1qX75Cyclin-dependent kinase 22.7.11.220.478
3roy22ZCyclin-dependent kinase 22.7.11.220.478
3pj8404Cyclin-dependent kinase 22.7.11.220.477
1g5sI17Cyclin-dependent kinase 22.7.11.220.476
1h1q2A6Cyclin-dependent kinase 22.7.11.220.476
2duv371Cyclin-dependent kinase 22.7.11.220.475
3qwkX62Cyclin-dependent kinase 22.7.11.220.475
3r9dX6BCyclin-dependent kinase 22.7.11.220.475
3rkb12ZCyclin-dependent kinase 22.7.11.220.475
4fklCK2Cyclin-dependent kinase 22.7.11.220.475
4fkr45KCyclin-dependent kinase 22.7.11.220.475
4fkv61KCyclin-dependent kinase 22.7.11.220.475
3ezvEZVCyclin-dependent kinase 22.7.11.220.474
4bcoT6QCyclin-dependent kinase 22.7.11.220.474
2r3r6SCCyclin-dependent kinase 22.7.11.220.473
3sw719KCyclin-dependent kinase 22.7.11.220.473
4eon1ROCyclin-dependent kinase 22.7.11.220.473
1ykr628Cyclin-dependent kinase 22.7.11.220.471
2vu3LZECyclin-dependent kinase 22.7.11.220.471
3r8pZ46Cyclin-dependent kinase 22.7.11.220.471
4erwSTUCyclin-dependent kinase 22.7.11.220.471
1gii1PUCyclin-dependent kinase 22.7.11.220.470
2vttLZDCyclin-dependent kinase 22.7.11.220.469
3qtzX42Cyclin-dependent kinase 22.7.11.220.469
4bgh3I6Cyclin-dependent kinase 22.7.11.220.469
2c6kDT2Cyclin-dependent kinase 22.7.11.220.468
3r9hZ67Cyclin-dependent kinase 22.7.11.220.465
4fko20KCyclin-dependent kinase 22.7.11.220.465
2r3fSC8Cyclin-dependent kinase 22.7.11.220.464
3rak03ZCyclin-dependent kinase 22.7.11.220.464
4nifANPMitogen-activated protein kinase 12.7.11.240.464
1oiuN76Cyclin-dependent kinase 22.7.11.220.463
3qqkX02Cyclin-dependent kinase 22.7.11.220.463
3qtuX44Cyclin-dependent kinase 22.7.11.220.462
3rpv26ZCyclin-dependent kinase 22.7.11.220.462
3sw418KCyclin-dependent kinase 22.7.11.220.462
5cnnANPEpidermal growth factor receptor2.7.10.10.462
2vthLZ2Cyclin-dependent kinase 22.7.11.220.461
2wotZZGTGF-beta receptor type-12.7.11.300.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
2ds11CDCyclin-dependent kinase 22.7.11.220.460
2r3mSCXCyclin-dependent kinase 22.7.11.220.460
3qziX72Cyclin-dependent kinase 22.7.11.220.460
3rk507ZCyclin-dependent kinase 22.7.11.220.460
4fks46KCyclin-dependent kinase 22.7.11.220.460
2y9qANPMitogen-activated protein kinase 12.7.11.240.459
3nynSGVG protein-coupled receptor kinase 62.7.11.160.459
4eok4SPCyclin-dependent kinase 22.7.11.220.459
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.458
2wpa889Cyclin-dependent kinase 22.7.11.220.456
3qruX19Cyclin-dependent kinase 22.7.11.220.456
3qtrX36Cyclin-dependent kinase 22.7.11.220.456
1gz8MBPCyclin-dependent kinase 22.7.11.220.453
1oiyN41Cyclin-dependent kinase 22.7.11.220.453
3ral04ZCyclin-dependent kinase 22.7.11.220.453
4bcmT7ZCyclin-dependent kinase 22.7.11.220.453
2x1nX1NCyclin-dependent kinase 22.7.11.220.452
1eh4IC1Casein kinase I homolog 12.7.11.10.451
1urwI1PCyclin-dependent kinase 22.7.11.220.451
2btsU32Cyclin-dependent kinase 22.7.11.220.451
1pxpCK8Cyclin-dependent kinase 22.7.11.220.450
1vyw292Cyclin-dependent kinase 22.7.11.220.450
2c69CT8Cyclin-dependent kinase 22.7.11.220.450
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.450
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.450
3qtxX43Cyclin-dependent kinase 22.7.11.220.450
3raiX85Cyclin-dependent kinase 22.7.11.220.450
4cfnJYMCyclin-dependent kinase 22.7.11.220.450
3r9nZ68Cyclin-dependent kinase 22.7.11.220.449
3rmf20ZCyclin-dependent kinase 22.7.11.220.449
2j9mPY8Cyclin-dependent kinase 22.7.11.220.448
4fkpLS5Cyclin-dependent kinase 22.7.11.220.448
1ckpPVBCyclin-dependent kinase 22.7.11.220.447
1vyzN5BCyclin-dependent kinase 22.7.11.220.447
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1p2a5BNCyclin-dependent kinase 22.7.11.220.446
1ke5LS1Cyclin-dependent kinase 22.7.11.220.445
1ke9LS5Cyclin-dependent kinase 22.7.11.220.445
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.445
3ti1B49Cyclin-dependent kinase 22.7.11.220.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.444
1pxkCK3Cyclin-dependent kinase 22.7.11.220.444
2vtqLZACyclin-dependent kinase 22.7.11.220.444
3ql8X01Cyclin-dependent kinase 22.7.11.220.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.444
4fki09KCyclin-dependent kinase 22.7.11.220.444
4fkt48KCyclin-dependent kinase 22.7.11.220.444
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
2bhhRYUCyclin-dependent kinase 22.7.11.220.442
1pxjCK2Cyclin-dependent kinase 22.7.11.220.441
3r8uZ31Cyclin-dependent kinase 22.7.11.220.441
3unj0BXCyclin-dependent kinase 22.7.11.220.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1r78FMDCyclin-dependent kinase 22.7.11.220.440
4fkw62KCyclin-dependent kinase 22.7.11.220.440