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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1q99ANPSerine/threonine-protein kinase SKY12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1q99ANPSerine/threonine-protein kinase SKY12.7.11.11.000
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.550
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.532
3lltANPProtein serine/threonine kinase-1/0.529
4ic7ANPMitogen-activated protein kinase 72.7.11.240.527
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.519
4j99ACPFibroblast growth factor receptor 2/0.519
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.517
3begANPSRSF protein kinase 12.7.11.10.515
3igoANPCalmodulin-domain protein kinase 1, putative/0.513
2ijmADPFocal adhesion kinase 12.7.10.20.508
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.504
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.502
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.501
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.500
2ojj82AMitogen-activated protein kinase 12.7.11.240.499
3c4xATPRhodopsin kinase/0.497
2cjmATPCyclin-dependent kinase 22.7.11.220.494
4qnyANPMitogen activated protein kinase, putative/0.494
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2zjwREFCasein kinase II subunit alpha2.7.11.10.492
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.492
4j95ACPFibroblast growth factor receptor 2/0.492
2j0lANPFocal adhesion kinase 12.7.10.20.490
4aguD15Cyclin-dependent kinase-like 1/0.489
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.484
4hvi19STyrosine-protein kinase JAK32.7.10.20.484
4ix6ADPUncharacterized protein/0.484
5av3KMPDeath-associated protein kinase 12.7.11.10.483
5cvfATPCasein kinase II subunit alpha2.7.11.10.483
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.482
4ez50RSCyclin-dependent kinase 62.7.11.220.481
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.481
2uzbC75Cyclin-dependent kinase 22.7.11.220.480
5av2KMPDeath-associated protein kinase 12.7.11.10.480
4eooATPCyclin-dependent kinase 22.7.11.220.478
2yaaATPDeath-associated protein kinase 2/0.476
2vu3LZECyclin-dependent kinase 22.7.11.220.474
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.474
4l9i8PRRhodopsin kinase/0.474
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.473
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4dtaADNAPH(2'')-Id/0.473
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.473
4hgs15GCasein kinase I isoform gamma-32.7.11.10.472
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.471
3zewSTUEphrin type-B receptor 42.7.10.10.471
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.471
3juhANPCasein kinase II subunit alpha2.7.11.10.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.470
3dfcANPDeath-associated protein kinase 12.7.11.10.469
3t8oATPRhodopsin kinase/0.468
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.468
2vtqLZACyclin-dependent kinase 22.7.11.220.467
3u4uLNHCasein kinase II subunit alpha2.7.11.10.467
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.466
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.466
4bcmT7ZCyclin-dependent kinase 22.7.11.220.465
4jia1K3Tyrosine-protein kinase JAK2/0.464
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.463
2j0m4STFocal adhesion kinase 12.7.10.20.462
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3zh8C58Protein kinase C iota type2.7.11.130.461
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.461
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.460
3q9xEMOCasein kinase II subunit alpha2.7.11.10.460
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4btjADPTau-tubulin kinase 12.7.11.10.457
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.457
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.457
1fvv107Cyclin-dependent kinase 22.7.11.220.455
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.455
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.454
2ckeIQUDeath-associated protein kinase 2/0.454
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3ncz3NCRho-associated protein kinase 12.7.11.10.454
3nux3NVCyclin-dependent kinase 62.7.11.220.454
4ii5ADPCyclin-dependent kinase 22.7.11.220.454
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2vttLZDCyclin-dependent kinase 22.7.11.220.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
4ysjADPCalmodulin-like domain protein kinase/0.453
1finATPCyclin-dependent kinase 22.7.11.220.452
1i44ACPInsulin receptor2.7.10.10.452
5e8ySTUTGF-beta receptor type-22.7.11.300.452
1jklANPDeath-associated protein kinase 12.7.11.10.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
1mqbANPEphrin type-A receptor 22.7.10.10.451
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.451
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.450
2uzdC85Cyclin-dependent kinase 22.7.11.220.450
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.450
4jqeANPCasein kinase II subunit alpha2.7.11.10.450
2fvdLIACyclin-dependent kinase 22.7.11.220.449
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.449
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2pvmP29Casein kinase II subunit alpha2.7.11.10.448
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
2izsBRQCasein kinase I isoform gamma-32.7.11.10.447
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2w17I19Cyclin-dependent kinase 22.7.11.220.446
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.446
4btjATPTau-tubulin kinase 12.7.11.10.446
4ix5ANPUncharacterized protein/0.446
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.444
3c4wATPRhodopsin kinase/0.444
3gu7ADPDeath-associated protein kinase 12.7.11.10.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.444
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.444
4nk92K5Fibroblast growth factor receptor 1/0.444
3a8wATPProtein kinase C iota type2.7.11.130.443
4bchT7ZCyclin-dependent kinase 92.7.11.220.443
5aut2ANDeath-associated protein kinase 12.7.11.10.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.442
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.441
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.441
3kvxFMYMitogen-activated protein kinase 102.7.11.240.441
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.441
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.440
2cchATPCyclin-dependent kinase 22.7.11.220.440
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3eb0DRKUncharacterized protein/0.440
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.440
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440