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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1q1rFADPutidaredoxin reductase1.18.1.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1q1rFADPutidaredoxin reductase1.18.1.51.000
1d7yFADFerredoxin reductase/0.593
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.556
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.10.534
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.509
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.499
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.498
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.498
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.481
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.472
1ppjANYCytochrome b/0.470
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
2wotZZGTGF-beta receptor type-12.7.11.300.468
3opdHIEHeat shock protein 83/0.468
1bygSTUTyrosine-protein kinase CSK/0.467
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.467
1fmlRTLRetinol dehydratase/0.465
3a4pDFQHepatocyte growth factor receptor2.7.10.10.465
1j39UPGDNA beta-glucosyltransferase/0.463
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.463
2btsU32Cyclin-dependent kinase 22.7.11.220.462
4fob0USALK tyrosine kinase receptor2.7.10.10.462
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.461
3friSAH16S rRNA methylase/0.461
1u4dDBQActivated CDC42 kinase 1/0.459
5kgpACOPredicted acetyltransferase/0.459
1x2hLPALipoate-protein ligase A6.3.1.200.458
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.458
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.457
3pqbVGPPutative oxidoreductase/0.457
3copADPGlycogen synthase2.4.1.210.456
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.455
2acxANPG protein-coupled receptor kinase 62.7.11.160.454
2qnqQN3Gag-Pol polyprotein3.4.23.160.454
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ix4ADPUncharacterized protein/0.453
1opbRETRetinol-binding protein 2/0.452
1v9aSAHUncharacterized protein/0.452
2y9qANPMitogen-activated protein kinase 12.7.11.240.451
3ddpRC8Cyclin-dependent kinase 22.7.11.220.451
3qlrNDPDihydrofolate reductase1.5.1.30.451
2cy0NAPShikimate dehydrogenase (NADP(+))/0.450
2pwcG3GGag-Pol polyprotein3.4.23.160.450
2qo9ANPEphrin type-A receptor 32.7.10.10.450
3inxJZCHeat shock protein HSP 90-alpha/0.450
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.450
4y8wSTRSteroid 21-hydroxylase/0.450
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.449
2cig1DGDihydrofolate reductase1.5.1.30.449
2iw94SPCyclin-dependent kinase 22.7.11.220.449
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.449
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
4tuvCPZCytochrome P450 1191.140.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
2qoqANPEphrin type-A receptor 32.7.10.10.448
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4dymIYZActivin receptor type-12.7.11.300.448
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4fv7E94Mitogen-activated protein kinase 12.7.11.240.448
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.447
2qo7ANPEphrin type-A receptor 32.7.10.10.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.447
5eowFAD6-hydroxynicotinate 3-monooxygenase1.14.13.1140.447
1idb0DOGag-Pol polyprotein/0.446
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
3ddqRRCCyclin-dependent kinase 22.7.11.220.445
3lctADPALK tyrosine kinase receptor2.7.10.10.445
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.445
5kf2ACOPredicted acetyltransferase/0.445
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.444
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1ojtFADDihydrolipoyl dehydrogenase/0.444
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.444
2oji33AMitogen-activated protein kinase 12.7.11.240.444
3el9DR7Gag-Pol polyprotein3.4.23.160.444
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.443
2c475IDCasein kinase I isoform gamma-2/0.443
2q631UNGag-Pol polyprotein3.4.23.160.443
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.443
4foc0UUALK tyrosine kinase receptor2.7.10.10.443
1e7qNAPGDP-L-fucose synthase/0.442
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
2zdt46CMitogen-activated protein kinase 102.7.11.240.442
3n8nN883-dehydroquinate dehydratase4.2.1.100.442
3nu9478Gag-Pol polyprotein3.4.23.160.442
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.442
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.442
4qo9627Serine/threonine-protein kinase 242.7.11.10.442
4xgxADPFAD:protein FMN transferase/0.442
1bsvNDPGDP-L-fucose synthase/0.441
1vyrFMNPentaerythritol tetranitrate reductase/0.441
2ckeIQUDeath-associated protein kinase 2/0.441
2jkqVG8Focal adhesion kinase 12.7.10.20.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
3ekqROCGag-Pol polyprotein3.4.23.160.441
3nu6478Gag-Pol polyprotein3.4.23.160.441
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4a28ADPKinesin-like protein KIF11/0.441
4fod0UVALK tyrosine kinase receptor2.7.10.10.441
4o1bDGBNicotinamide phosphoribosyltransferase2.4.2.120.441
5kgjACOPredicted acetyltransferase/0.441
1eh4IC1Casein kinase I homolog 12.7.11.10.440
1hdrNADDihydropteridine reductase1.5.1.340.440
1jpaANPEphrin type-B receptor 22.7.10.10.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
1zx9FADMercuric reductase1.16.1.10.440
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
2qhyMZ1Gag-Pol polyprotein/0.440
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.440
2ydwWSHBromodomain-containing protein 2/0.440
2z97CAMCamphor 5-monooxygenase1.14.15.10.440
3ggaGGWGag-Pol polyprotein/0.440
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3tvuB37Acetyl-CoA carboxylase/0.440
4b99R4LMitogen-activated protein kinase 72.7.11.240.440
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.440
4c02TAKActivin receptor type-12.7.11.300.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4ix5ANPUncharacterized protein/0.440
5kf1ACOPredicted acetyltransferase/0.440