Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rf2 NAP NADPH dependent R-specific alcohol dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 1.304
3qrw NDPPutative ketoacyl reductase 1.3.1 1.065
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.944
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.943
4dbz NDPPutative ketoacyl reductase 1.3.1 0.941
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.924
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.923
4hwk NAPSepiapterin reductase 1.1.1.153 0.919
1w4z NAPPutative ketoacyl reductase 1.3.1 0.917
1x7h NDPPutative ketoacyl reductase 1.3.1 0.917
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.917
3ai3 NDPNADPH-sorbose reductase / 0.916
4kwh NAPReductase homolog / 0.914
1x7g NAPPutative ketoacyl reductase 1.3.1 0.908
3ai2 NDPNADPH-sorbose reductase / 0.907
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.899
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.894
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.886
1ipe NDPTropinone reductase 2 1.1.1.236 0.878
4bmv NAPShort-chain dehydrogenase / 0.870
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.869
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.868
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.863
3geg NADShort-chain dehydrogenase/reductase SDR / 0.863
4j7u NAPSepiapterin reductase 1.1.1.153 0.861
3p19 NDPPutative blue fluorescent protein / 0.860
4j7x NAPSepiapterin reductase 1.1.1.153 0.860
4fn4 NADShort chain dehydrogenase / 0.853
3r3s NADPutative oxidoreductase / 0.852
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.848
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.847
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.840
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.837
4yag NAIC alpha-dehydrogenase / 0.836
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.835
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.832
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.831
3uce NDPDehydrogenase / 0.830
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.829
1oaa NAPSepiapterin reductase 1.1.1.153 0.827
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.826
5jla NADPutative short-chain dehydrogenase/reductase / 0.825
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.822
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.821
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.819
3u4c NDPNADPH-dependent reductase BacG / 0.818
3wds NADNADH-dependent quinuclidinone reductase / 0.815
1ae1 NAPTropinone reductase 1 / 0.814
4yai NAIC alpha-dehydrogenase / 0.813
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.812
2jah NDPClavaldehyde dehydrogenase / 0.812
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.811
4b79 NADProbable short-chain dehydrogenase / 0.810
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.808
3ak4 NADNADH-dependent quinuclidinone reductase / 0.807
3o26 NDPSalutaridine reductase / 0.806
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.804
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.802
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.801
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.799
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.788
2bd0 NAPSepiapterin reductase / 0.787
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.787
1pr9 NAPL-xylulose reductase 1.1.1.10 0.783
2c29 NAPDihydroflavonol 4-reductase / 0.783
2dte NAIGlucose 1-dehydrogenase related protein / 0.783
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.780
2wsb NADGalactitol dehydrogenase / 0.780
3tn7 NJPShort-chain alcohol dehydrogenase / 0.780
4wec NADShort chain dehydrogenase / 0.779
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.778
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.778
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.775
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.775
2yut NAPPutative short-chain oxidoreductase / 0.774
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.770
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.768
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.768
3d3w NAPL-xylulose reductase 1.1.1.10 0.766
3mje NDPAmphB / 0.765
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.765
1zem NADXylitol dehydrogenase / 0.763
3tsc NADUncharacterized protein / 0.762
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.761
2yy7 NADL-threonine dehydrogenase / 0.761
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.758
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.756
3bmo NAPPteridine reductase / 0.756
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.756
3sju NDPKeto reductase / 0.756
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.755
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.755
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.754
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.754
5jyd NADShort chain dehydrogenase / 0.754
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.753
3tox NAPPutative oxidoreductase / 0.751
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.750
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.750
3g49 NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.746
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.746
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.745
3h4v NAPPteridine reductase 1 1.5.1.33 0.744
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.743
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.741
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.739
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.737
4hxy NDPPlm1 / 0.737
2wdz NADGalactitol dehydrogenase / 0.736
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.736
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.735
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.732
1xkq NDPUncharacterized protein / 0.731
1sby NADAlcohol dehydrogenase 1.1.1.1 0.730
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.729
3l77 NJPShort-chain alcohol dehydrogenase / 0.729
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.726
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.726
4qed NAPElxO / 0.726
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.725
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.725
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.725
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.724
1iy8 NADLevodione reductase / 0.723
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.722
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.722
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.720
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.717
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.716
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.714
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.713
3icp NADNAD-dependent epimerase/dehydratase / 0.712
3a9w NADNDP-sugar epimerase / 0.710
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.710
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.710
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.709
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.708
3sx2 NADUncharacterized protein / 0.707
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.707
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.704
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.704
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.702
5hws NAP2-dehydropantoate 2-reductase / 0.702
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.701
4imp NDPPolyketide synthase extender modules 3-4 / 0.700
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.698
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.698
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.697
2rcy NAPPyrroline-5-carboxylate reductase / 0.696
3s55 NADPutative short-chain dehydrogenase/reductase / 0.695
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.695
4qec NAPElxO / 0.695
1i3l NADUDP-glucose 4-epimerase / 0.693
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.693
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.693
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.692
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.692
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.692
4eso NAPPutative oxidoreductase / 0.691
5d2e NAPMlnE / 0.690
1hdo NAPFlavin reductase (NADPH) / 0.689
3a1n NADNDP-sugar epimerase / 0.689
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.689
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.688
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.688
5lc1 NADL-threonine 3-dehydrogenase / 0.686
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.685
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.685
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.685
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.685
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.684
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.683
2bfo NDPPteridine reductase 1 1.5.1.33 0.683
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.683
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.683
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.682
3a4v NADNDP-sugar epimerase / 0.682
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.681
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.679
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.679
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.679
2p5y NADUDP-glucose 4-epimerase / 0.677
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.676
1g1a NADdTDP-glucose 4,6-dehydratase / 0.675
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.675
3ko8 NADNAD-dependent epimerase/dehydratase / 0.675
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.675
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.674
1ek5 NADUDP-glucose 4-epimerase / 0.674
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.674
3aw9 NADNAD-dependent epimerase/dehydratase / 0.674
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.674
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.673
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.673
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.672
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.671
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.671
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.670
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.670
1vrw NAIEnoyl-ACP reductase / 0.669
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.666
4b4o NDPEpimerase family protein SDR39U1 / 0.666
4egb NADdTDP-glucose 4,6-dehydratase / 0.666
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.664
4fw8 NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.663
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.662
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.662
3iup NDPPossible NADH oxidoreductase / 0.662
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.662
5b1y NDP3-oxoacyl-[acyl-carrier-protein] reductase / 0.661
1wnt NAPL-xylulose reductase 1.1.1.10 0.660
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.660
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.659
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.659
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.659
3h2s NDPPutative NADH-flavin reductase / 0.659
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.659
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.658
4idg NADPutative UDP-glucose 4-epimerase / 0.658
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.658
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.657
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.657
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.656
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.656
1djl NAPNAD(P) transhydrogenase, mitochondrial 1.6.1.2 0.655
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.655
3rkr NAPUncharacterized protein / 0.655
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.655
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.655
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.654
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.653
4y0k NAPAntE / 0.653
3wmx NADNAD dependent epimerase/dehydratase / 0.652
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.650
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.650
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.650
4tvb NADHomospermidine synthase 2.5.1.44 0.650