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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i8p NAD Aminoaldehyde dehydrogenase 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i8p NADAminoaldehyde dehydrogenase 1 / 1.296
4pz2 NADAldehyde dehydrogenase 2-6 / 1.121
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.111
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 1.070
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 1.058
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.052
4i8q NADPutative betaine aldehyde dehyrogenase / 1.014
3b4w NADAldehyde dehydrogenase family protein / 1.006
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.979
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.976
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.964
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.958
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.956
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.954
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.953
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.947
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.942
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.938
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.938
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.936
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.930
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.923
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.923
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.922
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.919
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.891
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.884
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.883
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.881
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.876
2jg7 NADAntiquitin / 0.864
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.863
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.863
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.841
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.830
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.822
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.810
3haz NADBifunctional protein PutA / 0.804
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.791
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.787
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.786
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.785
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.781
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.781
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.770
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.767
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.767
4l2o NADAldehyde dehydrogenase, dimeric NADP-preferring / 0.767
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.764
4pxl NADAldehyde dehydrogenase3 / 0.764
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.754
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.753
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.752
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.752
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.743
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.737
4f3x NADPutative aldehyde dehydrogenase / 0.736
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.725
4i3w NADAldehyde dehydrogenase (NAD+) / 0.724
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.717
4nmj NAPAldehyde dehydrogenase / 0.715
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.712
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.709
4c3s NADAldehyde Dehydrogenase / 0.707
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.706
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.706
4i9b NADPutative betaine aldehyde dehyrogenase / 0.702
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.700
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.699
4i3v NADAldehyde dehydrogenase (NAD+) / 0.698
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.692
4nmk NAPAldehyde dehydrogenase / 0.691
1bi9 NADRetinal dehydrogenase 2 / 0.689
1jq5 NADGlycerol dehydrogenase 1.1.1.6 0.688
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.688
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.687
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.684
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.682
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.680
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.666
5lc1 NADL-threonine 3-dehydrogenase / 0.664
3iwj NADAminoaldehyde dehydrogenase / 0.662
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.662
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.657
4pt0 NADAldehyde dehydrogenase / 0.655
4h73 NDPAldehyde dehydrogenase / 0.653
3wfj NAD2-dehydropantoate 2-reductase / 0.651
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651