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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aos FAD Steroid monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4aos FADSteroid monooxygenase / 1.261
4ap3 FADSteroid monooxygenase / 1.141
4aox FADSteroid monooxygenase / 1.062
4ap1 FADSteroid monooxygenase / 1.041
2gv8 FADThiol-specific monooxygenase 1.14.13 0.818
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.808
3lsh FADPyranose 2-oxidase / 0.806
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.796
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.789
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.777
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.774
2gvc FADThiol-specific monooxygenase 1.14.13 0.765
2hqm FADGlutathione reductase 1.8.1.7 0.762
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.752
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.750
2ign FADPyranose 2-oxidase / 0.746
4mok FADPyranose 2-oxidase / 0.744
4tlz FADKtzI / 0.738
2igo FADPyranose 2-oxidase / 0.736
3pl8 FADPyranose 2-oxidase / 0.736
3gwf FADCyclohexanone monooxygenase / 0.735
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.734
2xvf FADPutative flavin-containing monooxygenase / 0.731
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.730
2yqu FADDihydrolipoyl dehydrogenase / 0.726
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
3gwd FADCyclohexanone monooxygenase / 0.725
1ges FADGlutathione reductase 1.8.1.7 0.724
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.722
4tm0 FADKtzI / 0.722
4b65 FADL-ornithine N(5)-monooxygenase / 0.721
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.718
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.715
4fwf FADLysine-specific histone demethylase 1B 1 0.714
4mih FADPyranose 2-oxidase 1.1.3.10 0.713
3lsi FADPyranose 2-oxidase / 0.710
3k30 ADPHistamine dehydrogenase / 0.709
2eq8 FADDihydrolipoyl dehydrogenase / 0.708
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.708
3mj4 FADUDP-galactopyranose mutase / 0.708
3s5w FADL-ornithine N(5)-monooxygenase / 0.708
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.706
4b64 FADL-ornithine N(5)-monooxygenase / 0.706
4b68 FADL-ornithine N(5)-monooxygenase / 0.706
2r9z FADGlutathione amide reductase / 0.704
1yy5 FADPolyamine oxidase FMS1 / 0.703
2yg7 FADPutrescine oxidase / 0.702
3ict FADCoenzyme A disulfide reductase / 0.702
4cnk FADL-amino acid oxidase / 0.702
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.702
3urh FADDihydrolipoyl dehydrogenase / 0.701
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.700
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.699
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.699
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.698
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.698
2yg3 FADPutrescine oxidase / 0.698
4usr FADMonooxygenase / 0.698
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.696
3k4c FADPyranose 2-oxidase / 0.695
4tm3 FADKtzI / 0.694
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.693
4gcm FADThioredoxin reductase 1.8.1.9 0.693
2x3n FADProbable FAD-dependent monooxygenase / 0.692
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.691
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.691
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.690
2eq6 FADDihydrolipoyl dehydrogenase / 0.690
4b1b FADThioredoxin reductase 1.8.1.9 0.690
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.690
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.689
4d7e FADPutative lysine-N-oxygenase / 0.689
4c3x FAD3-ketosteroid dehydrogenase / 0.688
1nhq FADNADH peroxidase 1.11.1.1 0.687
2q7v FADThioredoxin reductase / 0.687
2x8h FADThioredoxin glutathione reductase / 0.687
4fwe FADLysine-specific histone demethylase 1B 1 0.687
4xbf FADLysine-specific histone demethylase 1A 1 0.687
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.685
1nhs FADNADH peroxidase 1.11.1.1 0.683
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.683
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.683
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.683
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.679
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.679
1gal FADGlucose oxidase 1.1.3.4 0.678
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.678
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.678
1f8w FADNADH peroxidase 1.11.1.1 0.677
1ojt FADDihydrolipoyl dehydrogenase / 0.677
3ish FADThioredoxin reductase 1.8.1.9 0.677
3vqr FADPutative oxidoreductase / 0.677
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.677
3k4n FADPyranose 2-oxidase / 0.676
4dna FADProbable glutathione reductase / 0.676
4gur FADLysine-specific histone demethylase 1B 1 0.676
3gyj FADCholesterol oxidase 1.1.3.6 0.675
1nhr FADNADH peroxidase 1.11.1.1 0.674
3cgb FADCoenzyme A disulfide reductase / 0.674
1ijh FADCholesterol oxidase 1.1.3.6 0.673
2yg4 FADPutrescine oxidase / 0.673
3rha FDAPutrescine oxidase / 0.673
3ute FADUDP-galactopyranose mutase / 0.673
4tm4 FDAKtzI / 0.673
3cn8 FADPolyamine oxidase FMS1 / 0.672
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.671
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.671
5hxw FADL-amino acid deaminase / 0.671
4gus FADLysine-specific histone demethylase 1B 1 0.670
1d7y FADFerredoxin reductase / 0.669
1fec FADTrypanothione reductase 1.8.1.12 0.669
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.669
3cox FADCholesterol oxidase 1.1.3.6 0.669
4yac NAIC alpha-dehydrogenase / 0.669
2tpr FADTrypanothione reductase 1.8.1.12 0.668
2yg5 FADPutrescine oxidase / 0.668
3t2k FADSulfide-quinone reductase / 0.668
1nhp FADNADH peroxidase 1.11.1.1 0.666
1z6l FADPolyamine oxidase FMS1 / 0.666
3cnd FADPolyamine oxidase FMS1 / 0.666
4gut FADLysine-specific histone demethylase 1B 1 0.666
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.666
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.665
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.665
4u2l SFDCholesterol oxidase 1.1.3.6 0.665
2b9w FADPutative aminooxidase / 0.664
2jb2 FADL-amino acid oxidase / 0.664
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
1joa FADNADH peroxidase 1.11.1.1 0.663
4qi4 FADCellobiose dehydrogenase / 0.663
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.663
1n4u FAECholesterol oxidase 1.1.3.6 0.662
1y56 ATPUncharacterized protein / 0.662
3gyi FADCholesterol oxidase 1.1.3.6 0.662
3hdy FADUDP-galactopyranose mutase / 0.662
2eq7 NADDihydrolipoyl dehydrogenase / 0.660
4c5o FADPutative monooxygenase / 0.660
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.660
4fwj FADLysine-specific histone demethylase 1B 1 0.660
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.659
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.658
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.658
1tdo FADL-amino-acid oxidase 1.4.3.2 0.657
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.657
4qi5 FADCellobiose dehydrogenase / 0.657
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.656
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.656
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.656
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.656
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.656
3qvr FADGlucose oxidase 1.1.3.4 0.656
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.655
2x8g FADThioredoxin glutathione reductase / 0.655
4xxg FADCholesterol oxidase 1.1.3.6 0.655
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.654
3hdy FDAUDP-galactopyranose mutase / 0.653
3rfx NADUronate dehydrogenase / 0.653
3cty FADProbable thioredoxin reductase / 0.652
3f8r NAPNADH oxidase/thioredoxin reductase / 0.652
2eq7 FADDihydrolipoyl dehydrogenase / 0.651
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.651
3he3 FADUDP-galactopyranose mutase / 0.651
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.650
2eq9 FADDihydrolipoyl dehydrogenase / 0.650
3bi2 FADPolyamine oxidase FMS1 / 0.650
4tm1 FDAKtzI / 0.650