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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t1k ANP Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3t1k ANPHeat shock protein HSP 90-alpha / 0.908
3t10 ACPHeat shock protein HSP 90-alpha / 0.894
3t0z ATPHeat shock protein HSP 90-alpha / 0.881
2yef ANPHeat shock protein HSP 90-alpha / 0.868
4xc0 ACPHeat shock cognate 90 kDa protein / 0.860
3t2s AGSHeat shock protein HSP 90-alpha / 0.832
4gqt ADPHeat shock protein 90 / 0.825
2xk2 ADPHeat shock protein HSP 90-alpha / 0.819
1byq ADPHeat shock protein HSP 90-alpha / 0.818
4xcl AGSHeat shock cognate 90 kDa protein / 0.815
4xcj ADPHeat shock cognate 90 kDa protein / 0.813
4wuc ANPDNA gyrase subunit B / 0.787
2ior ADPChaperone protein HtpG / 0.772
1yt0 ADPEndoplasmin / 0.768
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.764
4wud ANPDNA gyrase subunit B / 0.760
4ivg ANPTNF receptor-associated protein 1 / 0.739
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.736
2xcm ADPCytosolic heat shock protein 90 / 0.735
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.734
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.732
2wep ADPATP-dependent molecular chaperone HSP82 / 0.729
4prv ADPDNA gyrase subunit B / 0.727
2o1u ANPEndoplasmin / 0.721
4prx ADPDNA gyrase subunit B / 0.721
3zkb ANPDNA gyrase subunit B / 0.712
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.709
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.704
4gt8 ADPSensor protein VraS 2.7.13.3 0.702
3a0t ADPSensor histidine kinase / 0.701
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.697
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.696
3ied AN2HSP90 / 0.696
4ipe ANPTNF receptor-associated protein 1 / 0.695
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.694
3h4l ANPDNA mismatch repair protein PMS1 / 0.694
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.691
1y4s ADPChaperone protein HtpG / 0.688
1nhh ANPDNA mismatch repair protein MutL / 0.685
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.683
3sl2 ATPSensor histidine kinase WalK / 0.682
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.681
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.679
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.677
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.677
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.674
1amw ADPATP-dependent molecular chaperone HSP82 / 0.672
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.664
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.662
1ei1 ANPDNA gyrase subunit B / 0.661
2gqp PA7Endoplasmin / 0.659
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.658
1s16 ANPDNA topoisomerase 4 subunit B / 0.657
2yeg XQGHeat shock protein HSP 90-alpha / 0.655
4biw ANPSensor histidine kinase CpxA / 0.654
1th8 ADPAnti-sigma F factor / 0.652
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.651
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.651