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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3b2t M33 Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3b2t M33Fibroblast growth factor receptor 2 / 0.801
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.747
4e5i 0N9Polymerase acidic protein / 0.744
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.739
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.729
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.720
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.720
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.717
4j97 ACPFibroblast growth factor receptor 2 / 0.711
2pwl ACPFibroblast growth factor receptor 2 / 0.706
4j98 ACPFibroblast growth factor receptor 2 / 0.706
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.704
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.701
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.701
2pvy ACPFibroblast growth factor receptor 2 / 0.700
4dca ADPAminoglycoside phosphotransferase / 0.699
2yee 2ECHeat shock protein HSP 90-alpha / 0.697
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.694
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.693
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.689
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.689
4b8l A0PAurora kinase B-A 2.7.11.1 0.689
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.687
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.687
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.685
5l8k ADPAurora kinase A 2.7.11.1 0.685
4xhg ADPUncharacterized protein / 0.684
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.683
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.683
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.683
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.680
2vgo AD5Aurora kinase B-A 2.7.11.1 0.680
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.679
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.679
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.679
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.679
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.678
2exm ZIPCyclin-dependent kinase 2 2.7.11.22 0.677
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.677
3tin ADPTtl protein / 0.677
1u54 ACPActivated CDC42 kinase 1 / 0.675
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.674
3cly ACPFibroblast growth factor receptor 2 / 0.674
5l8j ADPAurora kinase A 2.7.11.1 0.673
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.671
4j95 ACPFibroblast growth factor receptor 2 / 0.671
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.671
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
3d5w ADPSerine/threonine-protein kinase PLK / 0.670
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.670
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.670
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.669
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.669
5ani ES4Cyclin-dependent kinase 2 2.7.11.22 0.669
5l8l ADPAurora kinase A 2.7.11.1 0.669
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.668
2cch ATPCyclin-dependent kinase 2 2.7.11.22 0.668
2pz5 ACPFibroblast growth factor receptor 2 / 0.668
2pzp ACPFibroblast growth factor receptor 2 / 0.668
1i59 ADPChemotaxis protein CheA 2.7.13.3 0.667
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.667
4k2r ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.667
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.667
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.666
2py3 ACPFibroblast growth factor receptor 2 / 0.666
4egi B2JHeat shock protein HSP 90-alpha / 0.666
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.665
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.665
4w9w YDJBMP-2-inducible protein kinase 2.7.11.1 0.665
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.665
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.664
3mv5 XFERAC-alpha serine/threonine-protein kinase 2.7.11.1 0.663
1vhz APRADP compounds hydrolase NudE 3.6.1 0.662
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.662
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.661
4r3a ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.661
2i8c ADPD-alanine--D-alanine ligase / 0.660
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.659
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.659
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
4wzy ATPMaltokinase 2.7.1.175 0.659
1h0v UN4Cyclin-dependent kinase 2 2.7.11.22 0.657
1oiy N41Cyclin-dependent kinase 2 2.7.11.22 0.657
2uw0 GVKcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.656
4blt APCNTPase P4 / 0.656
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.654
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3cqu CQURAC-alpha serine/threonine-protein kinase 2.7.11.1 0.654
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.654
4lrz ADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL 2.7 0.654
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.653
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.653
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.652
3w0p ADPHygromycin-B 4-O-kinase 2.7.1.163 0.651
4oti MI1Serine/threonine-protein kinase N1 / 0.651
2wqe ADPAurora kinase A 2.7.11.1 0.650
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.650
4fkl CK2Cyclin-dependent kinase 2 2.7.11.22 0.650