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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xuu ADP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.965
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.871
3c4z ADPRhodopsin kinase / 0.849
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.847
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.834
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.830
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.820
3qc9 ADPRhodopsin kinase / 0.813
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.812
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.811
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.808
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.805
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.804
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.793
5dos ATPAurora kinase A 2.7.11.1 0.791
5dr2 ATPAurora kinase A 2.7.11.1 0.791
3c50 ADPRhodopsin kinase / 0.790
5dt3 ATPAurora kinase A 2.7.11.1 0.788
5dn3 ATPAurora kinase A 2.7.11.1 0.787
3c4w ATPRhodopsin kinase / 0.781
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.772
3t8o ATPRhodopsin kinase / 0.769
2pup ADPMethylthioribose kinase 2.7.1.100 0.767
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.765
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.764
2pyw ADPMethylthioribose kinase 2.7.1.100 0.763
2pui ADPMethylthioribose kinase 2.7.1.100 0.762
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.761
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.760
4ceg ADPAurora kinase A 2.7.11.1 0.758
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.758
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.757
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.757
3cly ACPFibroblast growth factor receptor 2 / 0.756
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.756
4utd ACPAurora kinase A 2.7.11.1 0.755
5dnr ATPAurora kinase A 2.7.11.1 0.754
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
5drd ATPAurora kinase A 2.7.11.1 0.748
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.747
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.744
4n57 ADPAPH(2'')-Id / 0.744
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.743
4ork GDPBifunctional AAC/APH 2.3.1 0.742
5dt4 ATPAurora kinase A 2.7.11.1 0.742
1u54 ACPActivated CDC42 kinase 1 / 0.741
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.738
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.738
4q5h ANPProtein kinase OspG 2.7 0.738
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.737
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.737
5ce3 ADPProtein kinase YopO / 0.737
5iqf GDPBifunctional AAC/APH 2.3.1 0.737
5l8j ADPAurora kinase A 2.7.11.1 0.737
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.736
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.735
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.733
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.732
4c3r ACPAurora kinase A 2.7.11.1 0.732
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.730
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.730
4dee ADPAurora kinase A 2.7.11.1 0.729
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.728
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.728
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.727
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.727
5iqh GNPBifunctional AAC/APH 2.3.1 0.727
2pun ACPMethylthioribose kinase 2.7.1.100 0.726
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.726
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.725
4xlv ACPInsulin receptor 2.7.10.1 0.725
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
2pul ACPMethylthioribose kinase 2.7.1.100 0.723
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.721
5iqb GNPBifunctional AAC/APH 2.3.1 0.721
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.720
2pz5 ACPFibroblast growth factor receptor 2 / 0.720
4bn1 ADPAurora kinase A 2.7.11.1 0.720
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.718
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.718
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.717
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
1ol6 ATPAurora kinase A 2.7.11.1 0.716
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
1mq4 ADPAurora kinase A 2.7.11.1 0.714
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.713
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.713
3q5i ANPProtein kinase, putative / 0.713
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.713
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.713
2py3 ACPFibroblast growth factor receptor 2 / 0.712
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.711
2dwb ANPAurora kinase A 2.7.11.1 0.711
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.711
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.710
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.710
4qny ANPMitogen activated protein kinase, putative / 0.709
4ysj ADPCalmodulin-like domain protein kinase / 0.709
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.708
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.708
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.708
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.707
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.706
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.705
2olc ADPMethylthioribose kinase 2.7.1.100 0.704
3bu5 ATPInsulin receptor 2.7.10.1 0.704
3c4x ATPRhodopsin kinase / 0.704
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.703
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.702
4jrn ANPRhoptry kinase family protein / 0.701
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.700
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.700
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3oro AGSSerine/threonine protein kinase / 0.698
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.696
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.696
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.696
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.695
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.695
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.695
3tdw GDPGentamicin resistance protein / 0.694
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.694
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.694
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.693
3pff ADPATP-citrate synthase 2.3.3.8 0.693
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.693
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.692
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.692
2yaa ATPDeath-associated protein kinase 2 / 0.691
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.691
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.691
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.691
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.690
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.688
3ori AGSSerine/threonine protein kinase / 0.688
5byl GCPBifunctional AAC/APH 2.3.1 0.688
1cm8 ANPMitogen-activated protein kinase 12 / 0.687
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.687
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.687
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.686
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.686
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.684
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.684
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.683
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.683
5l8l ADPAurora kinase A 2.7.11.1 0.682
2vqd AP2Biotin carboxylase 6.3.4.14 0.681
3wnz ADPAlanine--anticapsin ligase / 0.681
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.680
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.680
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.679
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.679
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4ffm ADPUncharacterized protein / 0.678
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.677
3t7o UPGGlycogenin-1 2.4.1.186 0.677
3tdv GDPGentamicin resistance protein / 0.677
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.677
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
5iqi GNPBifunctional AAC/APH 2.3.1 0.677
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.676
5iqa GNPBifunctional AAC/APH 2.3.1 0.676
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.675
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.673
3r5f ATPD-alanine--D-alanine ligase / 0.673
1m0w ANPGlutathione synthetase 6.3.2.3 0.672
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.672
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.672
3orp AGSSerine/threonine protein kinase / 0.671
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.671
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.670
2wqe ADPAurora kinase A 2.7.11.1 0.670
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.670
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.668
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.668
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.667
1ol5 ADPAurora kinase A 2.7.11.1 0.666
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
3nie ANPMitogen-activated protein kinase / 0.666
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.665
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
2pzp ACPFibroblast growth factor receptor 2 / 0.663
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.663
4ix5 ANPUncharacterized protein / 0.663
4o4e ATPKinase / 0.663
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.662
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.662
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.662
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.661
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.661
5iqd GNPBifunctional AAC/APH 2.3.1 0.661
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.660
5c3a URMHisto-blood group ABO system transferase / 0.660
3ork AGSSerine/threonine protein kinase / 0.659
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.659
4zgn ATPCell division cycle protein 123 / 0.659
5ios FADFlavin-dependent thymidylate synthase 2.1.1.148 0.659
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.658
4c3p ACPAurora kinase A 2.7.11.1 0.658
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
5iqe GNPBifunctional AAC/APH 2.3.1 0.657
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.656
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.655
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.655
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
4fhp UTPTerminal uridylyltransferase cid1 / 0.655
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.655
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
5l8k ADPAurora kinase A 2.7.11.1 0.655
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.654
2fju GSPRas-related C3 botulinum toxin substrate 1 / 0.653
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.653
3wo1 ADPAlanine--anticapsin ligase / 0.653
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.652
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.652
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.652
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.652
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.651
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.651
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.650
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.650
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.650
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.650