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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vhw NAI Alanine dehydrogenase 1.4.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vhw NAIAlanine dehydrogenase 1.4.1.1 1.198
2vhz NAIAlanine dehydrogenase 1.4.1.1 1.129
2vhx NADAlanine dehydrogenase 1.4.1.1 1.073
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.942
2voj NADAlanine dehydrogenase 1.4.1.1 0.915
3adp NAILambda-crystallin 1.1.1.45 0.803
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.762
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.761
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.756
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.744
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.743
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.741
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.741
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.740
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.739
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.734
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.731
1pjc NADAlanine dehydrogenase / 0.730
4j4b NAIUncharacterized protein / 0.729
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.728
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.728
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.727
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.727
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.725
2g5c NADPrephenate dehydrogenase / 0.724
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.724
3jv7 NADSecondary alcohol dehydrogenase / 0.724
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.723
1uxk NADMalate dehydrogenase / 0.722
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.720
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.719
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.718
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.718
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.718
4lcj NADC-terminal-binding protein 2 / 0.718
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.718
3q2k NAIProbable oxidoreductase / 0.717
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.716
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.715
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.715
4j49 NAIUncharacterized protein / 0.714
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.712
4k28 NADShikimate dehydrogenase family protein / 0.712
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.711
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.711
3uko NADAlcohol dehydrogenase class-3 / 0.711
4j43 NADUncharacterized protein / 0.709
4j49 NADUncharacterized protein / 0.709
1uxj NADMalate dehydrogenase / 0.708
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.706
3d64 NADAdenosylhomocysteinase / 0.705
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.704
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.703
3ggp NADPrephenate dehydrogenase / 0.702
3wle NAD(R)-specific carbonyl reductase / 0.702
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.702
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.701
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.701
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.700
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.699
4jji NADAlcohol dehydrogenase class-3 / 0.699
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.698
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.696
3wv8 ATPHmd co-occurring protein HcgE / 0.696
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.695
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.695
1f8f NADBenzyl alcohol dehydrogenase / 0.694
3ggo NAIPrephenate dehydrogenase / 0.694
4c4o NADSADH / 0.694
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.693
1pzh NADLactate dehydrogenase / 0.692
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.692
2npx NADNADH peroxidase 1.11.1.1 0.692
4l0q NADAlcohol dehydrogenase class-3 / 0.692
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.691
3m2t NADProbable dehydrogenase / 0.691
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.690
1o6z NADMalate dehydrogenase / 0.690
3wsw NADL-lactate dehydrogenase / 0.690
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.689
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.687
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.687
3keo NADRedox-sensing transcriptional repressor Rex / 0.687
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.687
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.687
1vi2 NADQuinate/shikimate dehydrogenase / 0.686
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.686
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.685
5a02 NAPGlucose-fructose oxidoreductase / 0.685
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.685
1vjt NADAlpha-glucosidase, putative / 0.684
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.684
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.684
2ph5 NADHomospermidine synthase / 0.682
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.682
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
4xyb NDPFormate dehydrogenase / 0.680
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.679
3ec7 NADInositol 2-dehydrogenase / 0.679
4z0p NDPNAD-dependent dehydrogenase / 0.679
1emd NADMalate dehydrogenase / 0.678
3kb6 NADD-lactate dehydrogenase / 0.678
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.677
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.677
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.677
3mj4 FADUDP-galactopyranose mutase / 0.677
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.677
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.676
1sow NADL-lactate dehydrogenase 1.1.1.27 0.676
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.676
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.676
5a05 NDPGlucose-fructose oxidoreductase / 0.676
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.675
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.675
3wv7 ADPHmd co-occurring protein HcgE / 0.675
5a03 NDPGlucose-fructose oxidoreductase / 0.675
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.674
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.674
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.674
4weq NAPNAD-dependent dehydrogenase / 0.674
1u7h NADPutative ornithine cyclodeaminase / 0.673
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.673
1x7d NADPutative ornithine cyclodeaminase / 0.672
2fkn NADUrocanate hydratase 4.2.1.49 0.672
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.672
3two NDPMannitol dehydrogenase / 0.672
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.672
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
1bdm NAXMalate dehydrogenase / 0.671
1guy NADMalate dehydrogenase / 0.671
2a92 NAIL-lactate dehydrogenase / 0.671
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.671
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.671
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.670
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.670
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.670
5a06 NDPGlucose-fructose oxidoreductase / 0.670
2hu2 NADC-terminal binding protein 1 / 0.669
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.669
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.668
1hku NADC-terminal-binding protein 1 1.1.1 0.667
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.667
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.667
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.667
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.667
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.666
3ggg NADPrephenate dehydrogenase / 0.666
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.666
5a1t NAIL-lactate dehydrogenase / 0.666
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.664
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.663
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.663
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.663
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.662
2cda NAPGlucose 1-dehydrogenase / 0.662
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.662
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.661
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.661
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.660
3gvi ADPMalate dehydrogenase / 0.660
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.660
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.660
1ib6 NADMalate dehydrogenase / 0.659
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.659
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.658
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.658
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.658
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.657
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.657
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.656
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.656
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.655
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.655
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.654
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.654
2b4r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.654
5a04 NDPGlucose-fructose oxidoreductase / 0.654
1c1d NAIPhenylalanine dehydrogenase / 0.653
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.653
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.653
1ebu NDAHomoserine dehydrogenase 1.1.1.3 0.652
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.652
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.652
4gl4 NAIAlcohol dehydrogenase class-3 / 0.652
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.651
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.650
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650
2ome NADC-terminal-binding protein 2 / 0.650
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.650