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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b9i ADP Mitogen-activated protein kinase FUS3 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 1.060
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 1.001
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.955
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.846
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.835
4dee ADPAurora kinase A 2.7.11.1 0.833
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.833
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.825
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.823
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.801
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.796
4xlv ACPInsulin receptor 2.7.10.1 0.794
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.791
3rv4 ADPBiotin carboxylase 6.3.4.14 0.791
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.790
1cm8 ANPMitogen-activated protein kinase 12 / 0.789
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
5dr2 ATPAurora kinase A 2.7.11.1 0.784
2vqd AP2Biotin carboxylase 6.3.4.14 0.783
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.776
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.770
2pyw ADPMethylthioribose kinase 2.7.1.100 0.769
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.766
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.763
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.759
5eg3 ACPFibroblast growth factor receptor 2 / 0.757
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.755
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.753
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.752
5dt3 ATPAurora kinase A 2.7.11.1 0.750
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.746
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.745
2olc ADPMethylthioribose kinase 2.7.1.100 0.744
2pui ADPMethylthioribose kinase 2.7.1.100 0.743
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.742
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.741
3g8d ADPBiotin carboxylase 6.3.4.14 0.739
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.738
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.738
4o1p ANPRibonuclease L / 0.737
1mq4 ADPAurora kinase A 2.7.11.1 0.736
1ol6 ATPAurora kinase A 2.7.11.1 0.736
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.735
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.735
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.734
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.732
5dos ATPAurora kinase A 2.7.11.1 0.732
3bu5 ATPInsulin receptor 2.7.10.1 0.731
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.730
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.730
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.729
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.727
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.727
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.726
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.725
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.722
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.719
3nie ANPMitogen-activated protein kinase / 0.719
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
4ffr ATPUncharacterized protein / 0.719
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
5dnr ATPAurora kinase A 2.7.11.1 0.719
5drd ATPAurora kinase A 2.7.11.1 0.719
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.718
2py3 ACPFibroblast growth factor receptor 2 / 0.718
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.718
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.718
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.717
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.717
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.717
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.717
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.717
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.717
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.717
4ysj ADPCalmodulin-like domain protein kinase / 0.717
5ce3 ADPProtein kinase YopO / 0.716
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.713
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.713
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.712
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.711
4ceg ADPAurora kinase A 2.7.11.1 0.711
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.710
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.710
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.708
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.708
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.708
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4utd ACPAurora kinase A 2.7.11.1 0.708
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.707
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.707
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.707
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.705
2pml ANPUncharacterized protein / 0.705
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.705
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.704
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.704
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.704
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4c3r ACPAurora kinase A 2.7.11.1 0.703
2pz5 ACPFibroblast growth factor receptor 2 / 0.702
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.702
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.701
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.701
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.699
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.699
5dn3 ATPAurora kinase A 2.7.11.1 0.699
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.697
4bn1 ADPAurora kinase A 2.7.11.1 0.697
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.697
4qny ANPMitogen activated protein kinase, putative / 0.697
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
2j9g ADPBiotin carboxylase 6.3.4.14 0.695
3c4z ADPRhodopsin kinase / 0.694
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.693
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.693
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4lv8 ADPRhoptry protein 5 C / 0.692
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.691
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.691
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.690
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.688
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.687
3c4w ATPRhodopsin kinase / 0.687
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.687
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.687
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1px2 ATPSynapsin-1 / 0.685
2dwb ANPAurora kinase A 2.7.11.1 0.685
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.685
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.684
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.683
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.682
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.682
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.681
1ol5 ADPAurora kinase A 2.7.11.1 0.681
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.681
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.681
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.681
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.681
4ffl ADPUncharacterized protein / 0.681
4gyi ADPUncharacterized protein / 0.681
5dt4 ATPAurora kinase A 2.7.11.1 0.681
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.680
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.680
3tw6 ADPPyruvate carboxylase / 0.679
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.678
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.678
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
3ori AGSSerine/threonine protein kinase / 0.677
3t8o ATPRhodopsin kinase / 0.677
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.676
2pzp ACPFibroblast growth factor receptor 2 / 0.676
3wo0 ADPAlanine--anticapsin ligase / 0.676
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.675
3c50 ADPRhodopsin kinase / 0.675
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.674
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.674
2el0 SAHDiphthine synthase / 0.674
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.674
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.672
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.672
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.670
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.670
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.670
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.670
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.669
2yaa ATPDeath-associated protein kinase 2 / 0.668
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.668
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.667
5l8k ADPAurora kinase A 2.7.11.1 0.667
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.666
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.665
2pup ADPMethylthioribose kinase 2.7.1.100 0.664
3qc9 ADPRhodopsin kinase / 0.664
4c3p ACPAurora kinase A 2.7.11.1 0.663
5iqe GNPBifunctional AAC/APH 2.3.1 0.663
1m0w ANPGlutathione synthetase 6.3.2.3 0.662
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.662
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.662
3pff ADPATP-citrate synthase 2.3.3.8 0.662
4zgn ATPCell division cycle protein 123 / 0.662
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.661
2pwl ACPFibroblast growth factor receptor 2 / 0.661
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.661
4ts7 ADPPurine phosphoribosyltransferase (GpT-1) / 0.661
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1mjh ATPUniversal stress protein MJ0577 / 0.659
2e7r SAHDiphthine synthase / 0.659
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.659
3a8t ATPAdenylate isopentenyltransferase / 0.659
3krf DSTGeranyl diphosphate synthase large subunit / 0.657
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.656
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.656
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.655
2el3 SAHDiphthine synthase / 0.654
2p6k SAHDiphthine synthase / 0.654
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.654
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.654
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.654
2e8s SAHDiphthine synthase / 0.653
2ejk SAHDiphthine synthase / 0.653
2p5c SAHDiphthine synthase / 0.653
2pci SAHDiphthine synthase / 0.652
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
3g8c ADPBiotin carboxylase 6.3.4.14 0.651
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.650
2uw0 GVKcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4ork GDPBifunctional AAC/APH 2.3.1 0.650
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.650