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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.11.000
3hmm855TGF-beta receptor type-12.7.11.300.556
1vjy460TGF-beta receptor type-12.7.11.300.533
3uyt0CKCasein kinase I isoform delta2.7.11.10.532
4c02TAKActivin receptor type-12.7.11.300.531
4bgg844Activin receptor type-12.7.11.300.530
3gxlQIGTGF-beta receptor type-12.7.11.300.529
1eh4IC1Casein kinase I homolog 12.7.11.10.523
4dymIYZActivin receptor type-12.7.11.300.522
3mtfA3FActivin receptor type-12.7.11.300.516
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.513
5e8wSTUTGF-beta receptor type-12.7.11.300.508
4g170VNCasein kinase I isoform gamma-32.7.11.10.506
4kbk1QGCasein kinase I isoform delta2.7.11.10.501
4f650S9Fibroblast growth factor receptor 1/0.497
2wotZZGTGF-beta receptor type-12.7.11.300.496
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.495
2pvhP19Casein kinase II subunit alpha2.7.11.10.493
4aacAAVMitogen-activated protein kinase 14/0.493
3be9P04Casein kinase II subunit alpha2.7.11.10.492
3w33W19Epidermal growth factor receptor2.7.10.10.492
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.491
3uzp0CKCasein kinase I isoform delta2.7.11.10.491
1rw8580TGF-beta receptor type-12.7.11.300.490
3zh8C58Protein kinase C iota type2.7.11.130.490
4dgnLU2Casein kinase II subunit alpha2.7.11.10.488
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.487
4qmzB49Serine/threonine-protein kinase 242.7.11.10.487
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.485
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.484
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.484
2wouZZFTGF-beta receptor type-12.7.11.300.483
3oom507Activin receptor type-12.7.11.300.483
4aqc88ATyrosine-protein kinase JAK2/0.481
3fln3FNMitogen-activated protein kinase 14/0.480
4lopSB4Mitogen-activated protein kinase 14/0.480
1g5sI17Cyclin-dependent kinase 22.7.11.220.479
4i22IREEpidermal growth factor receptor2.7.10.10.479
4loqSB4Mitogen-activated protein kinase 14/0.479
1om1IQACasein kinase II subunit alpha2.7.11.10.478
4kb81QOCasein kinase I isoform delta2.7.11.10.478
4nk92K5Fibroblast growth factor receptor 1/0.477
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.476
4hnf16WCasein kinase I isoform delta2.7.11.10.475
3gubGUBDeath-associated protein kinase 12.7.11.10.474
4aa4QC0Mitogen-activated protein kinase 14/0.474
1dawANPCasein kinase II subunit alpha2.7.11.10.473
1u4dDBQActivated CDC42 kinase 1/0.473
3rmf20ZCyclin-dependent kinase 22.7.11.220.473
4g160VMCasein kinase I isoform gamma-32.7.11.10.473
2pvlP55Casein kinase II subunit alpha2.7.11.10.472
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.472
1m2pHNACasein kinase II subunit alpha2.7.11.10.471
2itpAEEEpidermal growth factor receptor2.7.10.10.471
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.471
3hl7I47Mitogen-activated protein kinase 14/0.471
3s1h56ZCyclin-dependent kinase 22.7.11.220.471
2x1nX1NCyclin-dependent kinase 22.7.11.220.470
1xjdSTUProtein kinase C theta type2.7.11.130.469
2ghlLIBMitogen-activated protein kinase 14/0.469
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.469
4hvi19STyrosine-protein kinase JAK32.7.10.20.469
4looSB4Mitogen-activated protein kinase 14/0.469
4yuqKS1Calmodulin-like domain protein kinase/0.469
1py5PY1TGF-beta receptor type-12.7.11.300.468
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.468
3flwFLWMitogen-activated protein kinase 14/0.468
4iwd1JCHepatocyte growth factor receptor2.7.10.10.468
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3q43D66M1 family aminopeptidase3.4.110.467
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.466
4hge15VTyrosine-protein kinase JAK2/0.466
1gih1PUCyclin-dependent kinase 22.7.11.220.465
1oirHDYCyclin-dependent kinase 22.7.11.220.465
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2pmoHMDProtein kinase 7/0.465
2vv9IM9Cyclin-dependent kinase 22.7.11.220.465
1u54ACPActivated CDC42 kinase 1/0.464
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.464
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.464
1rfuADPPyridoxal kinase2.7.1.350.463
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.463
4f081RSTyrosine-protein kinase JAK2/0.463
1bsvNDPGDP-L-fucose synthase/0.462
1bwsNDPGDP-L-fucose synthase/0.462
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.462
4fkg4CKCyclin-dependent kinase 22.7.11.220.462
4hni16WCasein kinase I isoform epsilon2.7.11.10.462
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.462
2xa4AZ5Tyrosine-protein kinase JAK2/0.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.461
1rfvADPPyridoxal kinase2.7.1.350.460
2b52D42Cyclin-dependent kinase 22.7.11.220.460
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.460
2pvnP63Casein kinase II subunit alpha2.7.11.10.460
3nww3NWMitogen-activated protein kinase 14/0.460
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
2xikJ60Serine/threonine-protein kinase 252.7.11.10.459
2y6o1N1Ephrin type-A receptor 42.7.10.10.459
3ezvEZVCyclin-dependent kinase 22.7.11.220.459
3nynSGVG protein-coupled receptor kinase 62.7.11.160.459
4a4qUX9Pol protein/0.459
4ez50RSCyclin-dependent kinase 62.7.11.220.459
1di8DTQCyclin-dependent kinase 22.7.11.220.458
1hbvGANGag-Pol polyprotein/0.458
1pxoCK7Cyclin-dependent kinase 22.7.11.220.458
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.458
3cisATPUniversal stress protein Rv2623/0.458
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.458
4anmWULCasein kinase II subunit alpha2.7.11.10.458
4btjADPTau-tubulin kinase 12.7.11.10.458
4jia1K3Tyrosine-protein kinase JAK2/0.458
4k28NADShikimate dehydrogenase family protein/0.458
2csnCKICasein kinase I homolog 12.7.11.10.457
3hllI45Mitogen-activated protein kinase 14/0.457
3l8p0CEAngiopoietin-1 receptor2.7.10.10.457
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.457
4qmpDKISerine/threonine-protein kinase 242.7.11.10.457
1yvj4STTyrosine-protein kinase JAK32.7.10.20.456
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.456
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.456
2ien017Gag-Pol polyprotein3.4.23.160.456
2w17I19Cyclin-dependent kinase 22.7.11.220.456
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.456
3vs3VSETyrosine-protein kinase HCK2.7.10.20.456
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.456
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.456
4e4m0NHTyrosine-protein kinase JAK2/0.456
1csnATPCasein kinase I homolog 12.7.11.10.455
2b7aIZATyrosine-protein kinase JAK2/0.455
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.455
3slkNDPPolyketide synthase extender module 2/0.455
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.455
4gg70J8Hepatocyte growth factor receptor2.7.10.10.455
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.454
2q5g1FAPeroxisome proliferator-activated receptor delta/0.454
2vww7X2Ephrin type-B receptor 42.7.10.10.454
2w06FRVCyclin-dependent kinase 22.7.11.220.454
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.453
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.453
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3fklFKLMitogen-activated protein kinase 14/0.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4fkv61KCyclin-dependent kinase 22.7.11.220.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
5e8xSTUTGF-beta receptor type-12.7.11.300.453
1h1s4SPCyclin-dependent kinase 22.7.11.220.452
1jpaANPEphrin type-B receptor 22.7.10.10.452
1lbcCYZGlutamate receptor 2/0.452
2p5cSAHDiphthine synthase/0.452
2uzeC95Cyclin-dependent kinase 22.7.11.220.452
3dt1P40Mitogen-activated protein kinase 14/0.452
3pj8404Cyclin-dependent kinase 22.7.11.220.452
3u9eCOALmo1369 protein/0.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
4qnaX11Serine/threonine-protein kinase 242.7.11.10.452
5cnnANPEpidermal growth factor receptor2.7.10.10.452
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.451
2v7a627Tyrosine-protein kinase ABL12.7.10.20.451
2vx07X7Ephrin type-B receptor 42.7.10.10.451
3rak03ZCyclin-dependent kinase 22.7.11.220.451
3rni21ZCyclin-dependent kinase 22.7.11.220.451
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.451
4gk2L66Ephrin type-A receptor 32.7.10.10.451
4k33ACPFibroblast growth factor receptor 32.7.10.10.451
4kip1R9Mitogen-activated protein kinase 14/0.451
5e92ANPTGF-beta receptor type-22.7.11.300.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
2owkSAHDiphthine synthase/0.450
3ggfGVDSerine/threonine-protein kinase 26/0.450
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.450
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.450
4ewqMWLMitogen-activated protein kinase 14/0.450
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.450
4lxhC1EAlpha/beta hydrolase fold/0.450
1m2qMNXCasein kinase II subunit alpha2.7.11.10.449
2cchATPCyclin-dependent kinase 22.7.11.220.449
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.449
2izrBRKCasein kinase I isoform gamma-32.7.11.10.449
2pwlACPFibroblast growth factor receptor 2/0.449
2r3jSCJCyclin-dependent kinase 22.7.11.220.449
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.449
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4fkt48KCyclin-dependent kinase 22.7.11.220.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1xkkFMMEpidermal growth factor receptor2.7.10.10.448
3nwq2NCGag-Pol polyprotein3.4.23.160.448
3tz3B36Acetyl-CoA carboxylase/0.448
4gk3L87Ephrin type-A receptor 32.7.10.10.448
2b53D23Cyclin-dependent kinase 22.7.11.220.447
2ejvNADL-threonine 3-dehydrogenase/0.447
2g8yNADHydroxycarboxylate dehydrogenase B/0.447
2vwx7X4Ephrin type-B receptor 42.7.10.10.447
2y3sTIRTamL/0.447
3bhtMFRCyclin-dependent kinase 22.7.11.220.447
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3ibqATPPyridoxal kinase/0.447
3sw418KCyclin-dependent kinase 22.7.11.220.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
4dgo0JWCasein kinase II subunit alpha2.7.11.10.447
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4nj32KDCyclin-dependent kinase 22.7.11.220.447
1gii1PUCyclin-dependent kinase 22.7.11.220.446
1m2rMNYCasein kinase II subunit alpha2.7.11.10.446
1zz2B11Mitogen-activated protein kinase 14/0.446
2iw94SPCyclin-dependent kinase 22.7.11.220.446
2p3b3TLV-1 PROTEASE protein/0.446
2p3b3TLV-1 protease/0.446
2xyuQ9GEphrin type-A receptor 42.7.10.10.446
3qlrNDPDihydrofolate reductase1.5.1.30.446
3tqhNDPQuinone oxidoreductase/0.446
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.446
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4dgmAGICasein kinase II subunit alpha2.7.11.10.446
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.446
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.445
3mvl38PMitogen-activated protein kinase 14/0.445
3zmmF9JTyrosine-protein kinase JAK2/0.445
1dr3TAPDihydrofolate reductase1.5.1.30.444
1vikBAYGag-Pol polyprotein/0.444
1w6hTITPlasmepsin-23.4.23.390.444
1x8lOXRRetinol dehydratase/0.444
1y91CT9Cyclin-dependent kinase 22.7.11.220.444
1zemNADXylitol dehydrogenase/0.444
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
3ezrEZRCyclin-dependent kinase 22.7.11.220.444
3q44D50M1 family aminopeptidase3.4.110.444
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3zewSTUEphrin type-B receptor 42.7.10.10.444
4bgh3I6Cyclin-dependent kinase 22.7.11.220.444
4c61LMMTyrosine-protein kinase JAK2/0.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
4y93746Tyrosine-protein kinase/0.444
5e8ySTUTGF-beta receptor type-22.7.11.300.444
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.443
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.443
2eufLQQCyclin-dependent kinase 62.7.11.220.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.443
3own3OWRenin3.4.23.150.443
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.443
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.443
4lfiGNPCasein kinase II subunit alpha2.7.11.10.443
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.443
1p2a5BNCyclin-dependent kinase 22.7.11.220.442
1xddAAYIntegrin alpha-L/0.442
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.442
3w32W32Epidermal growth factor receptor2.7.10.10.442
4aua4AUCyclin-dependent kinase 62.7.11.220.442
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
1ykr628Cyclin-dependent kinase 22.7.11.220.441
2btsU32Cyclin-dependent kinase 22.7.11.220.441
2vwz7X6Ephrin type-B receptor 42.7.10.10.441
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.441
4a6nFADTetX family tetracycline inactivation enzyme/0.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4enhFVXCholesterol 24-hydroxylase/0.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.441
5cnoANPEpidermal growth factor receptor2.7.10.10.441
5d3qGDPDynamin-13.6.5.50.441
1ay0TPPTransketolase 12.2.1.10.440
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.440
1dayGNPCasein kinase II subunit alpha2.7.11.10.440
1fwkADPHomoserine kinase2.7.1.390.440
1k6tXN1Gag-Pol polyprotein3.4.23.160.440
1nvtNAPShikimate dehydrogenase (NADP(+))/0.440
1x8b824Wee1-like protein kinase2.7.10.20.440
1xl5190Gag-Pol polyprotein3.4.23.160.440
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.440
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.440
2p5fSAHDiphthine synthase/0.440
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.440
3pwrROCGag-Pol polyprotein3.4.23.160.440
3zep1NXTyrosine-protein kinase JAK32.7.10.20.440
3zxzKRWHepatocyte growth factor receptor2.7.10.10.440
4gmy0X5Tyrosine-protein kinase JAK2/0.440