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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.11.000
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.599
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.583
1pkdUCNCyclin-dependent kinase 22.7.11.220.517
4erwSTUCyclin-dependent kinase 22.7.11.220.515
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.514
3uli1N3Cyclin-dependent kinase 22.7.11.220.511
4qmpDKISerine/threonine-protein kinase 242.7.11.10.510
3r9dX6BCyclin-dependent kinase 22.7.11.220.502
1g5sI17Cyclin-dependent kinase 22.7.11.220.499
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.497
1gih1PUCyclin-dependent kinase 22.7.11.220.496
3rmf20ZCyclin-dependent kinase 22.7.11.220.496
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.496
4gmy0X5Tyrosine-protein kinase JAK2/0.496
4jqeANPCasein kinase II subunit alpha2.7.11.10.494
2x1nX1NCyclin-dependent kinase 22.7.11.220.493
1oi9N20Cyclin-dependent kinase 22.7.11.220.490
2i40BLZCyclin-dependent kinase 22.7.11.220.490
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.490
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.488
1oiyN41Cyclin-dependent kinase 22.7.11.220.487
2hog710Serine/threonine-protein kinase Chk12.7.11.10.487
3roy22ZCyclin-dependent kinase 22.7.11.220.487
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.486
4bcqTJFCyclin-dependent kinase 22.7.11.220.483
5e8wSTUTGF-beta receptor type-12.7.11.300.483
4anmWULCasein kinase II subunit alpha2.7.11.10.482
1di8DTQCyclin-dependent kinase 22.7.11.220.481
1h1s4SPCyclin-dependent kinase 22.7.11.220.481
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.481
1aq1STUCyclin-dependent kinase 22.7.11.220.480
1urwI1PCyclin-dependent kinase 22.7.11.220.480
3r9oZ71Cyclin-dependent kinase 22.7.11.220.480
3rpv26ZCyclin-dependent kinase 22.7.11.220.480
4eok4SPCyclin-dependent kinase 22.7.11.220.480
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.480
2uzdC85Cyclin-dependent kinase 22.7.11.220.479
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.479
1oiuN76Cyclin-dependent kinase 22.7.11.220.478
2bheBRYCyclin-dependent kinase 22.7.11.220.478
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.478
4c61LMMTyrosine-protein kinase JAK2/0.478
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.477
2iw84SPCyclin-dependent kinase 22.7.11.220.477
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.477
3qu0X40Cyclin-dependent kinase 22.7.11.220.477
2cchATPCyclin-dependent kinase 22.7.11.220.476
2iw94SPCyclin-dependent kinase 22.7.11.220.476
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.476
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.475
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.475
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.475
1v1k3FPCyclin-dependent kinase 22.7.11.220.474
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.474
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.474
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.474
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.474
2eufLQQCyclin-dependent kinase 62.7.11.220.473
2pvnP63Casein kinase II subunit alpha2.7.11.10.473
3rak03ZCyclin-dependent kinase 22.7.11.220.473
3zep1NXTyrosine-protein kinase JAK32.7.10.20.472
4hvh19RTyrosine-protein kinase JAK32.7.10.20.472
1h1r6CPCyclin-dependent kinase 22.7.11.220.471
4bcpT3CCyclin-dependent kinase 22.7.11.220.471
3qtzX42Cyclin-dependent kinase 22.7.11.220.470
3s1h56ZCyclin-dependent kinase 22.7.11.220.470
4fkv61KCyclin-dependent kinase 22.7.11.220.470
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.470
2c5nCK8Cyclin-dependent kinase 22.7.11.220.469
2c6tDT5Cyclin-dependent kinase 22.7.11.220.469
3ddpRC8Cyclin-dependent kinase 22.7.11.220.469
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.468
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.468
1xjdSTUProtein kinase C theta type2.7.11.130.467
3be9P04Casein kinase II subunit alpha2.7.11.10.467
4e4m0NHTyrosine-protein kinase JAK2/0.467
4ez50RSCyclin-dependent kinase 62.7.11.220.467
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.466
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.466
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.466
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.466
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.466
1bygSTUTyrosine-protein kinase CSK/0.465
1e9hINRCyclin-dependent kinase 22.7.11.220.465
4bchT7ZCyclin-dependent kinase 92.7.11.220.465
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.465
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.465
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
3lfnA27Cyclin-dependent kinase 22.7.11.220.464
3r9hZ67Cyclin-dependent kinase 22.7.11.220.464
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.464
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.464
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.463
3tnwF18Cyclin-dependent kinase 22.7.11.220.463
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.462
2vu3LZECyclin-dependent kinase 22.7.11.220.462
2wotZZGTGF-beta receptor type-12.7.11.300.462
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.462
4dgo0JWCasein kinase II subunit alpha2.7.11.10.462
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.462
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.461
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.461
1tj0FADBifunctional protein PutA1.5.5.20.460
2wihP48Cyclin-dependent kinase 22.7.11.220.460
3rni21ZCyclin-dependent kinase 22.7.11.220.460
3zh8C58Protein kinase C iota type2.7.11.130.459
4dgnLU2Casein kinase II subunit alpha2.7.11.10.459
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.459
1y91CT9Cyclin-dependent kinase 22.7.11.220.458
2j0m4STFocal adhesion kinase 12.7.10.20.458
2uzlC94Cyclin-dependent kinase 22.7.11.220.458
3ral04ZCyclin-dependent kinase 22.7.11.220.458
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.458
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.457
2b52D42Cyclin-dependent kinase 22.7.11.220.457
2bhhRYUCyclin-dependent kinase 22.7.11.220.457
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.457
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.457
1vjy460TGF-beta receptor type-12.7.11.300.456
5cshATPCasein kinase II subunit alpha2.7.11.10.456
1gii1PUCyclin-dependent kinase 22.7.11.220.455
2pmlANPUncharacterized protein/0.455
2uzeC95Cyclin-dependent kinase 22.7.11.220.455
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.455
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.455
4bcoT6QCyclin-dependent kinase 22.7.11.220.455
1ke9LS5Cyclin-dependent kinase 22.7.11.220.454
3ti1B49Cyclin-dependent kinase 22.7.11.220.454
4c62XWWTyrosine-protein kinase JAK2/0.454
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.454
4qmySTUSerine/threonine-protein kinase 242.7.11.10.454
1gij2PUCyclin-dependent kinase 22.7.11.220.453
2f2cAP9Cyclin-dependent kinase 62.7.11.220.453
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.453
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.453
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.453
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
4hvi19STyrosine-protein kinase JAK32.7.10.20.453
4i22IREEpidermal growth factor receptor2.7.10.10.453
1oguST8Cyclin-dependent kinase 22.7.11.220.452
4bcnT9NCyclin-dependent kinase 22.7.11.220.452
1pyePM1Cyclin-dependent kinase 22.7.11.220.451
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.451
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.451
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
3ezrEZRCyclin-dependent kinase 22.7.11.220.451
3ezvEZVCyclin-dependent kinase 22.7.11.220.451
3l8p0CEAngiopoietin-1 receptor2.7.10.10.451
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.450
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.450
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.450
3qxpX64Cyclin-dependent kinase 22.7.11.220.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.449
2pmnK51Protein kinase 7/0.449
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.449
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.449
4fx360KCyclin-dependent kinase 22.7.11.220.449
4hvg19QTyrosine-protein kinase JAK32.7.10.20.449
1ke6LS2Cyclin-dependent kinase 22.7.11.220.448
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
2xikJ60Serine/threonine-protein kinase 252.7.11.10.448
2xmyCDKCyclin-dependent kinase 22.7.11.220.448
2xnbY8LCyclin-dependent kinase 22.7.11.220.448
3rkb12ZCyclin-dependent kinase 22.7.11.220.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.448
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
2b7aIZATyrosine-protein kinase JAK2/0.447
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.447
3gxlQIGTGF-beta receptor type-12.7.11.300.447
3rk507ZCyclin-dependent kinase 22.7.11.220.447
3sqq99ZCyclin-dependent kinase 22.7.11.220.447
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.447
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.447
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4gub0Y4Casein kinase II subunit alpha2.7.11.10.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
4nj32KDCyclin-dependent kinase 22.7.11.220.447
4riyADPEpidermal growth factor receptor2.7.10.10.447
5cvhADPCasein kinase II subunit alpha2.7.11.10.447
1h1pCMGCyclin-dependent kinase 22.7.11.220.446
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.446
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.446
3oom507Activin receptor type-12.7.11.300.446
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.446
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.446
4o8aFADBifunctional protein PutA1.2.1.880.446
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.445
2j0j4STFocal adhesion kinase 12.7.10.20.445
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.445
3qqkX02Cyclin-dependent kinase 22.7.11.220.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
4acm7YGCyclin-dependent kinase 22.7.11.220.445
4dgmAGICasein kinase II subunit alpha2.7.11.10.445
4eomATPCyclin-dependent kinase 22.7.11.220.445
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.444
3bhtMFRCyclin-dependent kinase 22.7.11.220.444
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.444
1dm2HMDCyclin-dependent kinase 22.7.11.220.443
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.443
2b55D31Cyclin-dependent kinase 22.7.11.220.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2in6839Wee1-like protein kinase2.7.10.20.443
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.443
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.443
3qwkX62Cyclin-dependent kinase 22.7.11.220.443
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
3vf9477Tyrosine-protein kinase SYK2.7.10.20.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.443
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.442
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.442
3ddqRRCCyclin-dependent kinase 22.7.11.220.442
3sw418KCyclin-dependent kinase 22.7.11.220.442
4bgg844Activin receptor type-12.7.11.300.442
4eoi1ROCyclin-dependent kinase 22.7.11.220.442
4qmzB49Serine/threonine-protein kinase 242.7.11.10.442
1w0xOLOCyclin-dependent kinase 22.7.11.220.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3qtuX44Cyclin-dependent kinase 22.7.11.220.441
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.441
4hge15VTyrosine-protein kinase JAK2/0.441
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.440
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.440
2btrU73Cyclin-dependent kinase 22.7.11.220.440
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.440
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.440
3rk909ZCyclin-dependent kinase 22.7.11.220.440
4bgh3I6Cyclin-dependent kinase 22.7.11.220.440
4eos1ROCyclin-dependent kinase 22.7.11.220.440
4y93746Tyrosine-protein kinase/0.440