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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fko20KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fko20KCyclin-dependent kinase 22.7.11.221.000
3unj0BXCyclin-dependent kinase 22.7.11.220.651
2xmyCDKCyclin-dependent kinase 22.7.11.220.644
3sw719KCyclin-dependent kinase 22.7.11.220.628
3qtzX42Cyclin-dependent kinase 22.7.11.220.624
3sw418KCyclin-dependent kinase 22.7.11.220.598
4acm7YGCyclin-dependent kinase 22.7.11.220.590
3qtxX43Cyclin-dependent kinase 22.7.11.220.586
3r9oZ71Cyclin-dependent kinase 22.7.11.220.581
3unk0BYCyclin-dependent kinase 22.7.11.220.575
4fkq42KCyclin-dependent kinase 22.7.11.220.572
3rak03ZCyclin-dependent kinase 22.7.11.220.570
3rpv26ZCyclin-dependent kinase 22.7.11.220.568
4fkv61KCyclin-dependent kinase 22.7.11.220.568
3py0SU9Cyclin-dependent kinase 22.7.11.220.567
3s1h56ZCyclin-dependent kinase 22.7.11.220.560
3r8lZ30Cyclin-dependent kinase 22.7.11.220.559
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.556
2w06FRVCyclin-dependent kinase 22.7.11.220.556
1pxmCK5Cyclin-dependent kinase 22.7.11.220.554
4fkt48KCyclin-dependent kinase 22.7.11.220.549
3rpy27ZCyclin-dependent kinase 22.7.11.220.547
4bgh3I6Cyclin-dependent kinase 22.7.11.220.547
3qtuX44Cyclin-dependent kinase 22.7.11.220.546
1urwI1PCyclin-dependent kinase 22.7.11.220.545
4ek816KCyclin-dependent kinase 22.7.11.220.545
2c6iDT1Cyclin-dependent kinase 22.7.11.220.544
4fkw62KCyclin-dependent kinase 22.7.11.220.544
4fks46KCyclin-dependent kinase 22.7.11.220.542
2w1hL0FCyclin-dependent kinase 22.7.11.220.541
3ral04ZCyclin-dependent kinase 22.7.11.220.540
3pxyJWSCyclin-dependent kinase 22.7.11.220.539
1ke6LS2Cyclin-dependent kinase 22.7.11.220.538
2xnbY8LCyclin-dependent kinase 22.7.11.220.537
3r9dX6BCyclin-dependent kinase 22.7.11.220.537
3rmf20ZCyclin-dependent kinase 22.7.11.220.537
1y91CT9Cyclin-dependent kinase 22.7.11.220.533
2btrU73Cyclin-dependent kinase 22.7.11.220.531
2btsU32Cyclin-dependent kinase 22.7.11.220.530
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.530
2uzoC62Cyclin-dependent kinase 22.7.11.220.528
2c6o4SPCyclin-dependent kinase 22.7.11.220.527
4ez30S0Cyclin-dependent kinase 22.7.11.220.527
2r3iSCFCyclin-dependent kinase 22.7.11.220.526
3rk507ZCyclin-dependent kinase 22.7.11.220.525
3rni21ZCyclin-dependent kinase 22.7.11.220.525
1y8yCT7Cyclin-dependent kinase 22.7.11.220.524
3qu0X40Cyclin-dependent kinase 22.7.11.220.524
4fkpLS5Cyclin-dependent kinase 22.7.11.220.523
3lfnA27Cyclin-dependent kinase 22.7.11.220.522
1ke5LS1Cyclin-dependent kinase 22.7.11.220.521
1pxpCK8Cyclin-dependent kinase 22.7.11.220.520
2vv9IM9Cyclin-dependent kinase 22.7.11.220.519
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.518
3ti1B49Cyclin-dependent kinase 22.7.11.220.518
3rk708ZCyclin-dependent kinase 22.7.11.220.516
3s2pPMUCyclin-dependent kinase 22.7.11.220.516
1oitHDTCyclin-dependent kinase 22.7.11.220.514
4ek610KCyclin-dependent kinase 22.7.11.220.514
1di8DTQCyclin-dependent kinase 22.7.11.220.513
1g5sI17Cyclin-dependent kinase 22.7.11.220.513
4fkg4CKCyclin-dependent kinase 22.7.11.220.513
1gih1PUCyclin-dependent kinase 22.7.11.220.511
1ke7LS3Cyclin-dependent kinase 22.7.11.220.511
1pxoCK7Cyclin-dependent kinase 22.7.11.220.511
2w17I19Cyclin-dependent kinase 22.7.11.220.511
3qqhX0ACyclin-dependent kinase 22.7.11.220.511
3r1yX76Cyclin-dependent kinase 22.7.11.220.510
3qtrX36Cyclin-dependent kinase 22.7.11.220.509
3sqq99ZCyclin-dependent kinase 22.7.11.220.509
2r3lSCWCyclin-dependent kinase 22.7.11.220.508
1p2a5BNCyclin-dependent kinase 22.7.11.220.506
3r9hZ67Cyclin-dependent kinase 22.7.11.220.505
3qzhX69Cyclin-dependent kinase 22.7.11.220.502
2a0cCK9Cyclin-dependent kinase 22.7.11.220.500
3ezvEZVCyclin-dependent kinase 22.7.11.220.500
1ke9LS5Cyclin-dependent kinase 22.7.11.220.499
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.499
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.499
1e1xNW1Cyclin-dependent kinase 22.7.11.220.498
3r8zZ63Cyclin-dependent kinase 22.7.11.220.498
2j9mPY8Cyclin-dependent kinase 22.7.11.220.496
3fz1B98Cyclin-dependent kinase 22.7.11.220.495
3uli1N3Cyclin-dependent kinase 22.7.11.220.495
1dm2HMDCyclin-dependent kinase 22.7.11.220.494
2iw84SPCyclin-dependent kinase 22.7.11.220.494
1ckpPVBCyclin-dependent kinase 22.7.11.220.492
1pxlCK4Cyclin-dependent kinase 22.7.11.220.492
1fvv107Cyclin-dependent kinase 22.7.11.220.491
2vthLZ2Cyclin-dependent kinase 22.7.11.220.491
3lfsA07Cyclin-dependent kinase 22.7.11.220.491
4fkj11KCyclin-dependent kinase 22.7.11.220.491
3raiX85Cyclin-dependent kinase 22.7.11.220.490
1w0xOLOCyclin-dependent kinase 22.7.11.220.489
2vttLZDCyclin-dependent kinase 22.7.11.220.489
3r7vZ02Cyclin-dependent kinase 22.7.11.220.489
3rjc06ZCyclin-dependent kinase 22.7.11.220.489
4qmpDKISerine/threonine-protein kinase 242.7.11.10.489
3qxoX65Cyclin-dependent kinase 22.7.11.220.488
4fkr45KCyclin-dependent kinase 22.7.11.220.488
1ykr628Cyclin-dependent kinase 22.7.11.220.486
3qruX19Cyclin-dependent kinase 22.7.11.220.486
3r1sX73Cyclin-dependent kinase 22.7.11.220.486
3r8vZ62Cyclin-dependent kinase 22.7.11.220.486
2bheBRYCyclin-dependent kinase 22.7.11.220.485
1oiyN41Cyclin-dependent kinase 22.7.11.220.484
1gii1PUCyclin-dependent kinase 22.7.11.220.482
1ke8LS4Cyclin-dependent kinase 22.7.11.220.482
2r3o2SCCyclin-dependent kinase 22.7.11.220.482
1h0w207Cyclin-dependent kinase 22.7.11.220.481
2c6lDT4Cyclin-dependent kinase 22.7.11.220.479
2r64740Cyclin-dependent kinase 22.7.11.220.479
1v1k3FPCyclin-dependent kinase 22.7.11.220.478
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.478
1h1s4SPCyclin-dependent kinase 22.7.11.220.477
2iw94SPCyclin-dependent kinase 22.7.11.220.477
2b52D42Cyclin-dependent kinase 22.7.11.220.476
3iggEFQCyclin-dependent kinase 22.7.11.220.476
3qtqX35Cyclin-dependent kinase 22.7.11.220.476
4fki09KCyclin-dependent kinase 22.7.11.220.476
2exmZIPCyclin-dependent kinase 22.7.11.220.475
1h1r6CPCyclin-dependent kinase 22.7.11.220.474
3rm719ZCyclin-dependent kinase 22.7.11.220.473
1oirHDYCyclin-dependent kinase 22.7.11.220.472
3r71X86Cyclin-dependent kinase 22.7.11.220.472
1gij2PUCyclin-dependent kinase 22.7.11.220.471
3qzgX67Cyclin-dependent kinase 22.7.11.220.471
1w8cN69Cyclin-dependent kinase 22.7.11.220.470
2r3kSCQCyclin-dependent kinase 22.7.11.220.469
1vyzN5BCyclin-dependent kinase 22.7.11.220.468
2eufLQQCyclin-dependent kinase 62.7.11.220.467
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.467
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.467
4erwSTUCyclin-dependent kinase 22.7.11.220.466
1oguST8Cyclin-dependent kinase 22.7.11.220.465
2r3p3SCCyclin-dependent kinase 22.7.11.220.465
3r73X87Cyclin-dependent kinase 22.7.11.220.465
1pxkCK3Cyclin-dependent kinase 22.7.11.220.464
3qqkX02Cyclin-dependent kinase 22.7.11.220.464
3r7uX96Cyclin-dependent kinase 22.7.11.220.463
2a4lRRCCyclin-dependent kinase 22.7.11.220.462
2bhhRYUCyclin-dependent kinase 22.7.11.220.462
3s0o50ZCyclin-dependent kinase 22.7.11.220.462
4fklCK2Cyclin-dependent kinase 22.7.11.220.462
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
2c5yMTWCyclin-dependent kinase 22.7.11.220.461
4fx360KCyclin-dependent kinase 22.7.11.220.461
4l4dCAMCamphor 5-monooxygenase1.14.15.10.461
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
3gxlQIGTGF-beta receptor type-12.7.11.300.458
3tnwF18Cyclin-dependent kinase 22.7.11.220.458
2uznC96Cyclin-dependent kinase 22.7.11.220.457
3pj8404Cyclin-dependent kinase 22.7.11.220.457
3rk909ZCyclin-dependent kinase 22.7.11.220.457
4bgg844Activin receptor type-12.7.11.300.457
2b55D31Cyclin-dependent kinase 22.7.11.220.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
3qzfX66Cyclin-dependent kinase 22.7.11.220.456
2r3r6SCCyclin-dependent kinase 22.7.11.220.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
3r7yZ04Cyclin-dependent kinase 22.7.11.220.455
3rpo24ZCyclin-dependent kinase 22.7.11.220.455
2b53D23Cyclin-dependent kinase 22.7.11.220.454
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.454
2c6kDT2Cyclin-dependent kinase 22.7.11.220.453
3dogNNNCyclin-dependent kinase 22.7.11.220.453
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
2r3fSC8Cyclin-dependent kinase 22.7.11.220.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.452
3le62BZCyclin-dependent kinase 22.7.11.220.451
4ejgNCTCytochrome P450 2A131.14.14.10.451
2vtsLZCCyclin-dependent kinase 22.7.11.220.450
3iok1P6Tyrosine-protein kinase JAK2/0.450
3r6xX84Cyclin-dependent kinase 22.7.11.220.449
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.449
1r78FMDCyclin-dependent kinase 22.7.11.220.448
3mdmFJZCholesterol 24-hydroxylase/0.448
4dgo0JWCasein kinase II subunit alpha2.7.11.10.448
1phgMYTCamphor 5-monooxygenase1.14.15.10.447
4dgnLU2Casein kinase II subunit alpha2.7.11.10.447
3rkb12ZCyclin-dependent kinase 22.7.11.220.446
4aqc88ATyrosine-protein kinase JAK2/0.446
4kd11QKCyclin-dependent kinase 22.7.11.220.446
3lfqA28Cyclin-dependent kinase 22.7.11.220.445
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
2r3gSC9Cyclin-dependent kinase 22.7.11.220.444
3qwkX62Cyclin-dependent kinase 22.7.11.220.444
4btjATPTau-tubulin kinase 12.7.11.10.444
4ii5ADPCyclin-dependent kinase 22.7.11.220.444
1iwiCAMCamphor 5-monooxygenase1.14.15.10.443
1oi9N20Cyclin-dependent kinase 22.7.11.220.443
3r83Z14Cyclin-dependent kinase 22.7.11.220.443
1h0vUN4Cyclin-dependent kinase 22.7.11.220.442
3qqfX07Cyclin-dependent kinase 22.7.11.220.442
3qtsX46Cyclin-dependent kinase 22.7.11.220.442
3qx2X63Cyclin-dependent kinase 22.7.11.220.442
3roy22ZCyclin-dependent kinase 22.7.11.220.442
4eomATPCyclin-dependent kinase 22.7.11.220.442
1me6IVSPlasmepsin-23.4.23.390.441
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
1pyePM1Cyclin-dependent kinase 22.7.11.220.441
2cppCAMCamphor 5-monooxygenase1.14.15.10.441
3bheBZNGag-Pol polyprotein3.4.23.160.441
3ddpRC8Cyclin-dependent kinase 22.7.11.220.441
3qwjX6ACyclin-dependent kinase 22.7.11.220.441
3r7eX88Cyclin-dependent kinase 22.7.11.220.441
3sheI85MAP kinase-activated protein kinase 32.7.11.10.441
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.441
2fvdLIACyclin-dependent kinase 22.7.11.220.440
2p83MR0Beta-secretase 13.4.23.460.440
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3r9nZ68Cyclin-dependent kinase 22.7.11.220.440
4hge15VTyrosine-protein kinase JAK2/0.440
4nj32KDCyclin-dependent kinase 22.7.11.220.440