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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3we45FIRibosomal protein S6 kinase beta-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3we45FIRibosomal protein S6 kinase beta-12.7.11.11.000
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.670
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.630
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.595
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.550
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.543
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.542
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.518
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.515
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.512
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.511
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.508
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.503
2c6eHPMAurora kinase A2.7.11.10.502
2hog710Serine/threonine-protein kinase Chk12.7.11.10.502
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.502
3bqr4RBDeath-associated protein kinase 3/0.502
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
3t8oATPRhodopsin kinase/0.500
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.499
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.498
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.497
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.495
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.494
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.493
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.492
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.492
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.488
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.487
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.486
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.485
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.485
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.484
3a7hATPSerine/threonine-protein kinase 242.7.11.10.483
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.483
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.483
4fv9E71Mitogen-activated protein kinase 12.7.11.240.483
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.481
2vgpAD6Aurora kinase B-A2.7.11.10.481
2x6dX6DAurora kinase A2.7.11.10.481
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.481
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.480
4aguD15Cyclin-dependent kinase-like 1/0.480
4c3pACPAurora kinase A2.7.11.10.477
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.476
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.476
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.475
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.475
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.474
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.474
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.474
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.474
4ii5ADPCyclin-dependent kinase 22.7.11.220.473
1zrzBI1Protein kinase C iota type2.7.11.130.472
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.469
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.469
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.468
1wvxBD4Death-associated protein kinase 12.7.11.10.468
3d7tSTUTyrosine-protein kinase CSK/0.468
3t113T1Gag-Pol polyprotein3.4.23.160.468
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.467
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.467
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.466
4c57FEFCyclin-G-associated kinase2.7.11.10.466
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.465
4izy1J2Mitogen-activated protein kinase 82.7.11.240.465
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.464
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
3a62STURibosomal protein S6 kinase beta-12.7.11.10.464
4c58824Cyclin-G-associated kinase2.7.11.10.464
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.464
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.463
3zewSTUEphrin type-B receptor 42.7.10.10.463
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.463
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.462
1xl2189Gag-Pol polyprotein3.4.23.160.461
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.461
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.460
4hnc0UTMandelate racemase/0.460
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2j0m4STFocal adhesion kinase 12.7.10.20.459
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.459
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.458
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.458
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.458
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.457
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.456
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.456
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.456
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.456
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.455
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.455
4c62XWWTyrosine-protein kinase JAK2/0.455
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.455
2ojj82AMitogen-activated protein kinase 12.7.11.240.454
2qblCAMCamphor 5-monooxygenase1.14.15.10.454
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.454
3ztxZTXAurora kinase B-A2.7.11.10.454
4fnyI3KALK tyrosine kinase receptor2.7.10.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.454
5eypLOCTubulin beta chain/0.454
1k6cMK1Gag-Pol polyprotein3.4.23.160.453
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.453
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.453
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.453
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.453
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.453
5ap57RODual specificity protein kinase TTK2.7.12.10.453
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4i3zADPCyclin-dependent kinase 22.7.11.220.452
2y3sTIRTamL/0.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2w1fL0FAurora kinase A2.7.11.10.450
2yxuATPPyridoxal kinase2.7.1.350.450
3at4CCKCasein kinase II subunit alpha2.7.11.10.450
3sx2NADUncharacterized protein/0.450
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.450
1ykdCMPAdenylate cyclase/0.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3nwxKVSGag-Pol polyprotein3.4.23.160.449
3uvqFS8Mitogen-activated protein kinase 14/0.449
4du82P0Mevalonate diphosphate decarboxylase/0.449
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
4q73FADBifunctional protein PutA/0.449
4qysPLRTryptophan synthase beta chain 24.2.1.200.449
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.448
1w2xRCPAcetyl-CoA carboxylase/0.448
2fy4COACholine O-acetyltransferase2.3.1.60.448
3a1nNADNDP-sugar epimerase/0.448
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.448
3t2yFADSulfide-quinone reductase/0.448
4aotGW8Serine/threonine-protein kinase 102.7.11.10.448
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
4l4cCAMCamphor 5-monooxygenase1.14.15.10.448
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.447
2ijmATPFocal adhesion kinase 12.7.10.20.447
2izt23DCasein kinase I isoform gamma-32.7.11.10.447
2vv9IM9Cyclin-dependent kinase 22.7.11.220.447
3iok1P6Tyrosine-protein kinase JAK2/0.447
4c4f7CEDual specificity protein kinase TTK2.7.12.10.447
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.447
4nr42LKCREB-binding protein/0.447
4xwtU5PRibonuclease J/0.447
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.446
2ejvNADL-threonine 3-dehydrogenase/0.446
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.446
4g3rCAMCamphor 5-monooxygenase1.14.15.10.446
4k8aK8AFocal adhesion kinase 12.7.10.20.446
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.445
3c4xATPRhodopsin kinase/0.445
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3u9eCOALmo1369 protein/0.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.445
4gk3L87Ephrin type-A receptor 32.7.10.10.445
4riyADPEpidermal growth factor receptor2.7.10.10.445
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.444
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.444
2henADPEphrin type-B receptor 22.7.10.10.444
2qa2FADPolyketide oxygenase CabE/0.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.444
3bheBZNGag-Pol polyprotein3.4.23.160.444
3icsADPCoenzyme A disulfide reductase/0.444
3nwq2NCGag-Pol polyprotein3.4.23.160.444
3vs3VSETyrosine-protein kinase HCK2.7.10.20.444
4f640S8Fibroblast growth factor receptor 1/0.444
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
4o0uADNAurora kinase A2.7.11.10.444
2c4g514Cyclin-dependent kinase 22.7.11.220.443
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
3cgeNDPCoenzyme A disulfide reductase/0.443
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.443
3pxkPXKFocal adhesion kinase 12.7.10.20.443
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4c4g7RODual specificity protein kinase TTK2.7.12.10.443
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.443
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ryvZEAProtein LlR18A/0.443
2csnCKICasein kinase I homolog 12.7.11.10.442
2qoqANPEphrin type-A receptor 32.7.10.10.442
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.442
1iwiCAMCamphor 5-monooxygenase1.14.15.10.441
1k6vXN2Gag-Pol polyprotein3.4.23.160.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.441
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.441
3icrCOACoenzyme A disulfide reductase/0.441
3opdHIEHeat shock protein 83/0.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4b7sQLECytochrome P450 monooxygenase PikC/0.441
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.441
4g1wG1WMitogen-activated protein kinase 82.7.11.240.441
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5bsgNAPPyrroline-5-carboxylate reductase/0.441
5l8lADPAurora kinase A2.7.11.10.441
1dz6CAMCamphor 5-monooxygenase1.14.15.10.440
1mqbANPEphrin type-A receptor 22.7.10.10.440
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.440
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.440
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2qboCAMCamphor 5-monooxygenase1.14.15.10.440
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.440
3jskAHZThiamine thiazole synthase/0.440
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4c4iX20Dual specificity protein kinase TTK2.7.12.10.440
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.440