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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.11.000
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.549
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.549
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.542
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.524
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.523
4ysjADPCalmodulin-like domain protein kinase/0.518
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.517
1jklANPDeath-associated protein kinase 12.7.11.10.515
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.510
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.510
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.509
2w4jADPDeath-associated protein kinase 12.7.11.10.506
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.505
2yaaATPDeath-associated protein kinase 2/0.501
2w05FRTCyclin-dependent kinase 22.7.11.220.499
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.499
5av2KMPDeath-associated protein kinase 12.7.11.10.498
4bcmT7ZCyclin-dependent kinase 22.7.11.220.497
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.496
3nynSGVG protein-coupled receptor kinase 62.7.11.160.493
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.492
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.491
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.491
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.488
3my5RFZCyclin-dependent kinase 22.7.11.220.486
3bqr4RBDeath-associated protein kinase 3/0.484
4l9i8PRRhodopsin kinase/0.484
2ckeIQUDeath-associated protein kinase 2/0.483
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.483
3gu7ADPDeath-associated protein kinase 12.7.11.10.482
2j0lANPFocal adhesion kinase 12.7.10.20.480
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.480
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.480
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.479
4dgmAGICasein kinase II subunit alpha2.7.11.10.478
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.477
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.477
2uzbC75Cyclin-dependent kinase 22.7.11.220.476
3c4xATPRhodopsin kinase/0.476
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.476
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.475
4jia1K3Tyrosine-protein kinase JAK2/0.475
5av3KMPDeath-associated protein kinase 12.7.11.10.475
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.474
3gu83GUDeath-associated protein kinase 12.7.11.10.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.473
2vu3LZECyclin-dependent kinase 22.7.11.220.471
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.470
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
4grb0XGCasein kinase II subunit alpha2.7.11.10.470
4aqc88ATyrosine-protein kinase JAK2/0.469
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.469
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
3bu5ATPInsulin receptor2.7.10.10.468
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.468
3qxpX64Cyclin-dependent kinase 22.7.11.220.467
3uvqFS8Mitogen-activated protein kinase 14/0.467
4anmWULCasein kinase II subunit alpha2.7.11.10.467
4wsqKSAAP2-associated protein kinase 12.7.11.10.467
3w2sW2REpidermal growth factor receptor2.7.10.10.466
3ztxZTXAurora kinase B-A2.7.11.10.466
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.466
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.465
4f081RSTyrosine-protein kinase JAK2/0.464
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.463
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.463
1ig1ANPDeath-associated protein kinase 12.7.11.10.462
2j9mPY8Cyclin-dependent kinase 22.7.11.220.462
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.462
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.462
4c4f7CEDual specificity protein kinase TTK2.7.12.10.462
4hvi19STyrosine-protein kinase JAK32.7.10.20.462
1om1IQACasein kinase II subunit alpha2.7.11.10.461
1m2pHNACasein kinase II subunit alpha2.7.11.10.459
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.459
2ijmADPFocal adhesion kinase 12.7.10.20.459
3gubGUBDeath-associated protein kinase 12.7.11.10.459
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.459
3i60E86Mitogen-activated protein kinase 12.7.11.240.458
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.458
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.457
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.457
3eb0DRKUncharacterized protein/0.456
3pe2E1BCasein kinase II subunit alpha2.7.11.10.456
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.456
2pvhP19Casein kinase II subunit alpha2.7.11.10.455
3axwTIDCasein kinase II subunit alpha2.7.11.10.455
4g1wG1WMitogen-activated protein kinase 82.7.11.240.455
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.454
5dosATPAurora kinase A2.7.11.10.454
1jkkANPDeath-associated protein kinase 12.7.11.10.453
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
3q9xEMOCasein kinase II subunit alpha2.7.11.10.453
3zewSTUEphrin type-B receptor 42.7.10.10.453
4aguD15Cyclin-dependent kinase-like 1/0.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
4o0wADNAurora kinase A2.7.11.10.453
1fvv107Cyclin-dependent kinase 22.7.11.220.452
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.452
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.452
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.451
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
3nux3NVCyclin-dependent kinase 62.7.11.220.451
4hge15VTyrosine-protein kinase JAK2/0.451
3js2VM1Fibroblast growth factor receptor 1/0.450
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.450
2xvdAS6Ephrin type-B receptor 42.7.10.10.449
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.449
4dgnLU2Casein kinase II subunit alpha2.7.11.10.449
4jbpYPHAurora kinase A2.7.11.10.449
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.448
4c3pACPAurora kinase A2.7.11.10.448
4btkDTQTau-tubulin kinase 12.7.11.10.446
4jajXU1Aurora kinase A2.7.11.10.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.445
3be9P04Casein kinase II subunit alpha2.7.11.10.445
1k6cMK1Gag-Pol polyprotein3.4.23.160.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.443
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.443
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
2fvdLIACyclin-dependent kinase 22.7.11.220.440
2ijmATPFocal adhesion kinase 12.7.10.20.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3lltANPProtein serine/threonine kinase-1/0.440
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.440
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.440
5dt0SKEAurora kinase A2.7.11.10.440