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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xae2XAKinesin-like protein KIF11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xae2XAKinesin-like protein KIF11/1.000
4bbgV02Kinesin-like protein KIF11/0.632
2x7eX7EKinesin-like protein KIF11/0.596
2wogZZDKinesin-like protein KIF11/0.577
3kenZZDKinesin-like protein KIF11/0.575
2iehMOYKinesin-like protein KIF11/0.573
4a51DQ8Kinesin-like protein KIF11/0.572
2x7dEGBKinesin-like protein KIF11/0.548
2fme3QCKinesin-like protein KIF11/0.539
2q2zMKKKinesin-like protein KIF11/0.538
2x2rX2OKinesin-like protein KIF11/0.538
3k5eK5EKinesin-like protein KIF11/0.536
1q0bNATKinesin-like protein KIF11/0.529
2x7cKZ9Kinesin-like protein KIF11/0.524
2gm12AZKinesin-like protein KIF11/0.523
3k3bL31Kinesin-like protein KIF11/0.514
1x88NATKinesin-like protein KIF11/0.485
1fvt106Cyclin-dependent kinase 22.7.11.220.483
3ddqRRCCyclin-dependent kinase 22.7.11.220.480
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4a5yG7XKinesin-like protein KIF11/0.476
4cfnJYMCyclin-dependent kinase 22.7.11.220.476
4qysPLRTryptophan synthase beta chain 24.2.1.200.474
2r3kSCQCyclin-dependent kinase 22.7.11.220.470
1oguST8Cyclin-dependent kinase 22.7.11.220.467
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.467
2b55D31Cyclin-dependent kinase 22.7.11.220.465
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
4eomATPCyclin-dependent kinase 22.7.11.220.464
4fkj11KCyclin-dependent kinase 22.7.11.220.464
4fkw62KCyclin-dependent kinase 22.7.11.220.464
1pxpCK8Cyclin-dependent kinase 22.7.11.220.463
2vv9IM9Cyclin-dependent kinase 22.7.11.220.463
1h1pCMGCyclin-dependent kinase 22.7.11.220.461
4enhFVXCholesterol 24-hydroxylase/0.461
1ke6LS2Cyclin-dependent kinase 22.7.11.220.460
2iw84SPCyclin-dependent kinase 22.7.11.220.460
4erwSTUCyclin-dependent kinase 22.7.11.220.460
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.460
1vyzN5BCyclin-dependent kinase 22.7.11.220.459
2ccu2D9Heat shock protein HSP 90-alpha/0.458
3rk507ZCyclin-dependent kinase 22.7.11.220.458
1w2xRCPAcetyl-CoA carboxylase/0.457
2btsU32Cyclin-dependent kinase 22.7.11.220.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
1fm4DXCMajor pollen allergen Bet v 1-L/0.456
3rk708ZCyclin-dependent kinase 22.7.11.220.456
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.456
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.456
1ke7LS3Cyclin-dependent kinase 22.7.11.220.455
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.455
2yj5ATPCopper-transporting ATPase/0.455
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.455
4eoi1ROCyclin-dependent kinase 22.7.11.220.455
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.454
3ha85JZMitogen-activated protein kinase 14/0.454
4acm7YGCyclin-dependent kinase 22.7.11.220.454
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4fkr45KCyclin-dependent kinase 22.7.11.220.454
4otiMI1Serine/threonine-protein kinase N1/0.454
4rcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.454
2yboSAHMethyltransferase/0.453
3r6xX84Cyclin-dependent kinase 22.7.11.220.453
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.453
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.453
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
3sqq99ZCyclin-dependent kinase 22.7.11.220.452
1ojtFADDihydrolipoyl dehydrogenase/0.451
2puuG2GMitogen-activated protein kinase 14/0.451
2r3lSCWCyclin-dependent kinase 22.7.11.220.451
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3rni21ZCyclin-dependent kinase 22.7.11.220.451
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.451
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.451
4jajXU1Aurora kinase A2.7.11.10.451
1kvkATPMevalonate kinase2.7.1.360.450
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
4ek610KCyclin-dependent kinase 22.7.11.220.450
4ivd15TTyrosine-protein kinase JAK1/0.450
5dpvSKEAurora kinase A2.7.11.10.450
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.449
3hub469Mitogen-activated protein kinase 14/0.449
3unj0BXCyclin-dependent kinase 22.7.11.220.449
4aguD15Cyclin-dependent kinase-like 1/0.449
1aylATPPhosphoenolpyruvate carboxykinase (ATP)/0.448
3lfnA27Cyclin-dependent kinase 22.7.11.220.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.447
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3k2xI5A2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.447
3ral04ZCyclin-dependent kinase 22.7.11.220.447
3rjc06ZCyclin-dependent kinase 22.7.11.220.447
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4fkt48KCyclin-dependent kinase 22.7.11.220.447
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.447
5iubCLRAdenosine receptor A2a/0.447
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.446
3aidARQGag-Pol polyprotein3.4.23.160.446
3ig7EFPCyclin-dependent kinase 22.7.11.220.446
4eos1ROCyclin-dependent kinase 22.7.11.220.446
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
1pyePM1Cyclin-dependent kinase 22.7.11.220.445
1q1wFADPutidaredoxin reductase1.18.1.50.445
2btrU73Cyclin-dependent kinase 22.7.11.220.445
2wi1ZZ2Heat shock protein HSP 90-alpha/0.445
2wipP49Cyclin-dependent kinase 22.7.11.220.445
3a8wATPProtein kinase C iota type2.7.11.130.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
4ez30S0Cyclin-dependent kinase 22.7.11.220.445
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.444
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.444
3t80CTN2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
4cf7ADPAdenylate kinase/0.444
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.444
1fm69CRRetinoic acid receptor RXR-alpha/0.443
1mznBM6Retinoic acid receptor RXR-alpha/0.443
2c5yMTWCyclin-dependent kinase 22.7.11.220.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.443
3d75NBBPheromone-binding protein ASP1/0.443
3qp0NI8Gag-Pol polyprotein3.4.23.160.443
3qrtX14Cyclin-dependent kinase 22.7.11.220.443
3ufnROCGag-Pol polyprotein/0.443
4as76LXKinesin-like protein KIF11/0.443
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.443
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.443
1fvv107Cyclin-dependent kinase 22.7.11.220.442
2cciATPCyclin-dependent kinase 22.7.11.220.442
2vu3LZECyclin-dependent kinase 22.7.11.220.442
2ye42FYHeat shock protein HSP 90-alpha/0.442
2yee2ECHeat shock protein HSP 90-alpha/0.442
3iggEFQCyclin-dependent kinase 22.7.11.220.442
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.442
3qtqX35Cyclin-dependent kinase 22.7.11.220.442
3rpr25ZCyclin-dependent kinase 22.7.11.220.442
4h3zSAHtRNA (guanine-N(1)-)-methyltransferase/0.442
4lb2DM5Serum albumin/0.442
1d4yTPVGag-Pol polyprotein3.4.23.160.441
1h1r6CPCyclin-dependent kinase 22.7.11.220.441
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.441
3rpo24ZCyclin-dependent kinase 22.7.11.220.441
3s00Z60Cyclin-dependent kinase 22.7.11.220.441
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.441
4yswNAIXanthine dehydrogenase/oxidase/0.441
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
2a1mCAMCamphor 5-monooxygenase1.14.15.10.440
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.440
3m0eATPTranscriptional regulator (NtrC family)/0.440