Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2etm7PYFocal adhesion kinase 12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2etm7PYFocal adhesion kinase 12.7.10.21.000
4k8aK8AFocal adhesion kinase 12.7.10.20.569
2j0lANPFocal adhesion kinase 12.7.10.20.561
2ijmATPFocal adhesion kinase 12.7.10.20.542
2ijmADPFocal adhesion kinase 12.7.10.20.516
2x9fX9FEphrin type-B receptor 42.7.10.10.514
2qoqANPEphrin type-A receptor 32.7.10.10.507
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.507
2xvdAS6Ephrin type-B receptor 42.7.10.10.505
3c4xATPRhodopsin kinase/0.505
2j0m4STFocal adhesion kinase 12.7.10.20.504
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.495
2v7a627Tyrosine-protein kinase ABL12.7.10.20.491
3t8oATPRhodopsin kinase/0.491
4gk4L90Ephrin type-A receptor 32.7.10.10.490
3c4wATPRhodopsin kinase/0.488
3c4zADPRhodopsin kinase/0.485
4jia1K3Tyrosine-protein kinase JAK2/0.483
2jkoBIJFocal adhesion kinase 12.7.10.20.480
2qo7ANPEphrin type-A receptor 32.7.10.10.480
3bu5ATPInsulin receptor2.7.10.10.480
4ysjADPCalmodulin-like domain protein kinase/0.479
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.478
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.477
3pxkPXKFocal adhesion kinase 12.7.10.20.474
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.470
2henADPEphrin type-B receptor 22.7.10.10.470
3qc9ADPRhodopsin kinase/0.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.470
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
3zewSTUEphrin type-B receptor 42.7.10.10.463
2hog710Serine/threonine-protein kinase Chk12.7.11.10.462
4b99R4LMitogen-activated protein kinase 72.7.11.240.462
4l9i8PRRhodopsin kinase/0.462
2qocANPEphrin type-A receptor 32.7.10.10.461
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
2pwlACPFibroblast growth factor receptor 2/0.459
1bygSTUTyrosine-protein kinase CSK/0.458
1u54ACPActivated CDC42 kinase 1/0.458
4gu94GUFocal adhesion kinase 12.7.10.20.458
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.458
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.457
3nynSGVG protein-coupled receptor kinase 62.7.11.160.457
2qo9ANPEphrin type-A receptor 32.7.10.10.456
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.456
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.456
2xp2VGHALK tyrosine kinase receptor2.7.10.10.455
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.455
3bqr4RBDeath-associated protein kinase 3/0.454
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.454
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.453
3my5RFZCyclin-dependent kinase 22.7.11.220.453
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.453
5auwQUEDeath-associated protein kinase 12.7.11.10.453
4bcmT7ZCyclin-dependent kinase 22.7.11.220.452
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.451
4i4e1BQFocal adhesion kinase 12.7.10.20.451
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
5aaaVGHALK tyrosine kinase receptor2.7.10.10.451
2py3ACPFibroblast growth factor receptor 2/0.450
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.450
4ansVGHALK tyrosine kinase receptor2.7.10.10.450
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.450
4brxKGWFocal adhesion kinase 12.7.10.20.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.449
2vwu7X1Ephrin type-B receptor 42.7.10.10.448
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.448
1i44ACPInsulin receptor2.7.10.10.447
1jkkANPDeath-associated protein kinase 12.7.11.10.447
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.447
4qo9627Serine/threonine-protein kinase 242.7.11.10.447
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.446
4cd0AWJALK tyrosine kinase receptor2.7.10.10.446
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.446
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
4gk2L66Ephrin type-A receptor 32.7.10.10.445
4k33ACPFibroblast growth factor receptor 32.7.10.10.445
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4jboWPHAurora kinase A2.7.11.10.444
2acxANPG protein-coupled receptor kinase 62.7.11.160.443
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.443
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.443
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.443
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.442
3k5uPFQAurora kinase A2.7.11.10.442
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1mp8ADPFocal adhesion kinase 12.7.10.20.441
4ic7ANPMitogen-activated protein kinase 72.7.11.240.441
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.441
4nks2M2Fibroblast growth factor receptor 1/0.441
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
5dosATPAurora kinase A2.7.11.10.441
1ir3ANPInsulin receptor2.7.10.10.440
2w4jADPDeath-associated protein kinase 12.7.11.10.440
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440