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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t40ID5Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1t40ID5Aldose reductase1.1.1.211.000
2pdmZSTAldose reductase1.1.1.210.765
1z8962PAldose reductase1.1.1.210.758
2iki388Aldose reductase1.1.1.210.742
1z3n3NAAldose reductase1.1.1.210.732
2dv0ZSTAldose reductase1.1.1.210.703
2ikj393Aldose reductase1.1.1.210.702
2hv5ZSTAldose reductase1.1.1.210.698
3g5eQ74Aldose reductase1.1.1.210.680
2fz9ZSTAldose reductase1.1.1.210.672
2i16LDTAldose reductase1.1.1.210.669
2duxZSTAldose reductase1.1.1.210.662
1t41ID5Aldose reductase1.1.1.210.659
4yu153NAldose reductase1.1.1.210.657
2qxwLDTAldose reductase1.1.1.210.656
3lqlLDTAldose reductase1.1.1.210.653
4gca2X9Aldose reductase1.1.1.210.652
2ikhLITAldose reductase1.1.1.210.651
3m4h388Aldose reductase1.1.1.210.650
2fz8ZSTAldose reductase1.1.1.210.647
2pdxZSTAldose reductase1.1.1.210.646
2pdc393Aldose reductase1.1.1.210.644
3ld5LDTAldose reductase1.1.1.210.639
3lboLDTAldose reductase1.1.1.210.638
3mb9ZSTAldose reductase1.1.1.210.636
2pdp393Aldose reductase1.1.1.210.635
3ghuLDTAldose reductase1.1.1.210.633
2pdu393Aldose reductase1.1.1.210.632
2i17LDTAldose reductase1.1.1.210.622
3t423T4Aldose reductase1.1.1.210.622
2pdfZSTAldose reductase1.1.1.210.621
1pwlBFIAldose reductase1.1.1.210.618
1us0LDTAldose reductase1.1.1.210.614
2pdbZSTAldose reductase1.1.1.210.611
3ghrLDTAldose reductase1.1.1.210.611
2pzn393Aldose reductase1.1.1.210.610
2pdh47DAldose reductase1.1.1.210.609
3lenZSTAldose reductase1.1.1.210.609
3lz5LDTAldose reductase1.1.1.210.605
3mc5393Aldose reductase1.1.1.210.602
3m64393Aldose reductase1.1.1.210.601
3ghtLDTAldose reductase1.1.1.210.600
3m0iZSTAldose reductase1.1.1.210.595
2duzZSTAldose reductase1.1.1.210.587
2pdg47DAldose reductase1.1.1.210.581
2pd5ZSTAldose reductase1.1.1.210.578
3ghsLDTAldose reductase1.1.1.210.578
2pdn47DAldose reductase1.1.1.210.571
2pdj393Aldose reductase1.1.1.210.570
1ieiZESAldose reductase1.1.1.210.567
2agtFIDAldose reductase1.1.1.210.558
1frbZSTAldose reductase-related protein 2/0.556
2pdq47DAldose reductase1.1.1.210.547
1ah3TOLAldose reductase1.1.1.210.523
2fzdTOLAldose reductase1.1.1.210.523
2pdlTOLAldose reductase1.1.1.210.515
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.512
2hvoZSTAldose reductase1.1.1.210.511
2pdwFIDAldose reductase1.1.1.210.501
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.499
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.490
4u163C0Muscarinic acetylcholine receptor M3/0.488
4dbw511Aldo-keto reductase family 1 member C3/0.482
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.479
1x1aSAMC-20 methyltransferase/0.478
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
2cbqTH2Neocarzinostatin/0.476
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.475
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2f2kTGGAldose reductase1.1.1.210.472
3mjrAC2Deoxycytidine kinase2.7.1.740.472
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.472
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
4phlPILPhosphodiesterase/0.471
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1yw7A41Methionine aminopeptidase 2/0.470
1lnmDTXBilin-binding protein/0.468
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.467
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
5liu388Aldo-keto reductase family 1 member B101.1.10.464
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.463
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
1ry0PG2Aldo-keto reductase family 1 member C3/0.462
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
1xf0ASDAldo-keto reductase family 1 member C3/0.461
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
1e66HUXAcetylcholinesterase3.1.1.70.460
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4hmn16JAldo-keto reductase family 1 member C3/0.460
3sn6P0GBeta-2 adrenergic receptor/0.460
2ea4F79Methionine aminopeptidase 2/0.459
2f3815MAldo-keto reductase family 1 member C3/0.459
2qx7NAPEugenol synthase 11.1.1.3180.459
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2zs9ADPPantothenate kinase2.7.1.330.458
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
1ekoI84Aldose reductase1.1.1.210.457
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.457
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.457
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2qimZEAClass 10 plant pathogenesis-related protein/0.457
1dx6GNTAcetylcholinesterase3.1.1.70.456
1u65CP0Acetylcholinesterase3.1.1.70.456
2oazI96Methionine aminopeptidase 2/0.456
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.456
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
2xuiTZ5Acetylcholinesterase3.1.1.70.454
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.453
1vkgCRIHistone deacetylase 83.5.1.980.453
2cmfF11Acetylcholinesterase3.1.1.70.453
3b82NADExotoxin A2.4.2.360.453
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3q9bB3NAcetylpolyamine amidohydrolase/0.453
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.452
1x1bSAHC-20 methyltransferase/0.452
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3hl0NADMaleylacetate reductase/0.452
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3r6iJMSAldo-keto reductase family 1 member C3/0.452
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4li61XOTankyrase-12.4.2.300.452
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
4e0u0MVCyclic dipeptide N-prenyltransferase/0.451
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3f3y4OABile salt sulfotransferase2.8.2.140.450
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.450
4bj9UHBTankyrase-22.4.2.300.450
4pnmNU1Tankyrase-22.4.2.300.450
1zgcA2EAcetylcholinesterase3.1.1.70.449
2cekN8TAcetylcholinesterase3.1.1.70.449
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.449
4dbs0HVAldo-keto reductase family 1 member C3/0.449
4wevSUZAldo-keto reductase family 1 member B101.1.10.449
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1s1rNAPAldo-keto reductase family 1 member C3/0.448
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.448
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2ckmAA7Acetylcholinesterase3.1.1.70.448
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.447
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.446
2xuoTZ4Acetylcholinesterase3.1.1.70.446
2zsdCOAPantothenate kinase2.7.1.330.446
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.446
3v35NTIAldose reductase1.1.1.210.446
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4kmzFOLFolate receptor beta/0.446
1votHUPAcetylcholinesterase3.1.1.70.445
2ga2A19Methionine aminopeptidase 2/0.445
2uuoLK3UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4xwtU5PRibonuclease J/0.445
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1yw9A84Methionine aminopeptidase 2/0.444
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
2fzbTOLAldose reductase1.1.1.210.444
2w6cBM4Acetylcholinesterase3.1.1.70.444
2xufTZ4Acetylcholinesterase3.1.1.70.444
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4dvi2IWTankyrase-12.4.2.300.444
4jtrIBPAldo-keto reductase family 1 member C2/0.444
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.443
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.443
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3e4vFMNUncharacterized protein/0.443
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4bfvZVVPantothenate kinase2.7.1.330.443
4dz5NAPAldo-keto reductase family 1 member C3/0.443
4jq1NPSAldo-keto reductase family 1 member C2/0.443
4k4eK4ETankyrase-12.4.2.300.443
2dw4FADLysine-specific histone demethylase 1A10.442
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.442
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.442
4jq3ZOMAldo-keto reductase family 1 member C2/0.442
4xo7NAPAldo-keto reductase family 1 member C2/0.442
5dsg0HKMuscarinic acetylcholine receptor M4/0.442
1vp5NAPOxidoreductase, aldo/keto reductase family/0.441
1zgbA1EAcetylcholinesterase3.1.1.70.441
2c6c24IGlutamate carboxypeptidase 23.4.17.210.441
2xi4AFTAcetylcholinesterase3.1.1.70.441
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3pn1IVHDNA ligase/0.441
4bfwZVWPantothenate kinase2.7.1.330.441
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.440
2rd2QSIGlutamine--tRNA ligase6.1.1.180.440
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
3af2ACPPantothenate kinase2.7.1.330.440
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.440
4dbuBT9Aldo-keto reductase family 1 member C3/0.440
4jtrIZPAldo-keto reductase family 1 member C2/0.440
4jyzATPGlutamine--tRNA ligase6.1.1.180.440
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4pnrG18Tankyrase-22.4.2.300.440