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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mr92BXGamma-aminobutyric acid type B receptor subunit 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/1.000
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.800
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.705
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.671
2g1y5IGRenin3.4.23.150.494
2il2LIXRenin3.4.23.150.490
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.487
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.487
2iko7IGRenin3.4.23.150.486
2ifaFMNUncharacterized protein/0.482
4j4nD44Peptidylprolyl isomerase/0.482
4bfxZVXPantothenate kinase2.7.1.330.478
2rlcCHDCholoylglycine hydrolase3.5.1.240.477
2rqfJH3Hemolymph juvenile hormone binding protein/0.474
2whqHI6Acetylcholinesterase3.1.1.70.473
3phiNDPShikimate dehydrogenase (NADP(+))/0.472
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.471
2gv8NDPThiol-specific monooxygenase1.14.130.471
5stdUNNScytalone dehydratase4.2.1.940.471
1rneC60Renin3.4.23.150.470
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.469
3wagTYDGlycosyltransferase/0.469
1qtiGNTAcetylcholinesterase3.1.1.70.468
4bftZVTPantothenate kinase2.7.1.330.468
5irnADPNucleotide binding oligomerization domain containing 2/0.468
2g1r3IGRenin3.4.23.150.467
2g247IGRenin3.4.23.150.467
4b63NAPL-ornithine N(5)-monooxygenase/0.467
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.467
2g1s4IGRenin3.4.23.150.466
4kbyC2EStimulator of interferon genes protein/0.466
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.465
3q43D66M1 family aminopeptidase3.4.110.465
3oqkS52Renin3.4.23.150.464
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.464
2jb4A14Isopenicillin N synthase1.21.3.10.463
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.463
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3hl0NADMaleylacetate reductase/0.463
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.463
1obnASVIsopenicillin N synthase1.21.3.10.462
4b68NAPL-ornithine N(5)-monooxygenase/0.462
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.461
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.461
4arbC57Acetylcholinesterase3.1.1.70.460
1g6kNADGlucose 1-dehydrogenase1.1.1.470.459
1xe55FEPlasmepsin-23.4.23.390.458
2g21L1BRenin3.4.23.150.458
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.458
3fhxPLPPyridoxal kinase2.7.1.350.458
3fktSIIBeta-secretase 13.4.23.460.458
4b66NAPL-ornithine N(5)-monooxygenase/0.458
4bfvZVVPantothenate kinase2.7.1.330.458
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.458
1ex75GPGuanylate kinase2.7.4.80.457
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.457
3d91REMRenin3.4.23.150.457
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.457
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.456
1z71L17Prothrombin3.4.21.50.456
2gevCOKPantothenate kinase2.7.1.330.456
2b58COADiamine acetyltransferase 1/0.455
2g226IGRenin3.4.23.150.455
3own3OXRenin3.4.23.150.454
4brgGNPEctonucleoside triphosphate diphosphohydrolase I/0.454
4usrFADMonooxygenase/0.454
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.453
2bn4FMNNADPH--cytochrome P450 reductase/0.452
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.452
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.452
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.452
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.451
1x1bSAHC-20 methyltransferase/0.451
2iviACWIsopenicillin N synthase1.21.3.10.451
2pncCLUPrimary amine oxidase, liver isozyme/0.451
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.451
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
2w6cBM4Acetylcholinesterase3.1.1.70.450
3ekuCY9Actin-5C/0.450
3vyfVYFRenin3.4.23.150.450
4bb3KKAIsopenicillin N synthase1.21.3.10.450
1w6hTITPlasmepsin-23.4.23.390.449
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.449
4mlp2CXCryptochrome-2/0.449
1gtrATPGlutamine--tRNA ligase6.1.1.180.448
1u65CP0Acetylcholinesterase3.1.1.70.448
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.448
2g1n1IGRenin3.4.23.150.448
3dzkNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.448
4araC56Acetylcholinesterase3.1.1.70.448
4ejvLCLTranscriptional regulator TcaR/0.448
4ey6GNTAcetylcholinesterase3.1.1.70.448
1bil0IURenin3.4.23.150.447
1culFOKAdenylate cyclase type 2/0.447
1culFOKAdenylate cyclase type 5/0.447
1h22E10Acetylcholinesterase3.1.1.70.447
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.447
2c29NAPDihydroflavonol 4-reductase/0.447
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.447
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.447
3oqfS51Renin3.4.23.150.447
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.447
1icpFMN12-oxophytodienoate reductase 11.3.1.420.446
2cekN8TAcetylcholinesterase3.1.1.70.446
2z1qFADAcyl-CoA dehydrogenase/0.446
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.446
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.446
1e66HUXAcetylcholinesterase3.1.1.70.445
1p0pBCHCholinesterase3.1.1.80.445
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.445
2zsaADPPantothenate kinase2.7.1.330.445
3af0GDPPantothenate kinase2.7.1.330.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
4oztP1AEcdysone receptor, putative/0.445
4r81FMNPredicted NADH dehydrogenase/0.445
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
1w4lGL8Acetylcholinesterase3.1.1.70.444
2cmfF11Acetylcholinesterase3.1.1.70.444
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.444
2zvbSAHPrecorrin-3 C17-methyltransferase/0.444
3ai3NDPNADPH-sorbose reductase/0.444
4a81DXCMajor pollen allergen Bet v 1-A/0.444
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
4lxa1YSBeta-secretase 13.4.23.460.444
4q0kGA3Phytohormone-binding protein/0.444
1eveE20Acetylcholinesterase3.1.1.70.443
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.443
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.443
1udaUFGUDP-glucose 4-epimerase5.1.3.20.443
2c20NADUDP-glucose 4-epimerase/0.443
2vbdV10Isopenicillin N synthase1.21.3.10.443
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.443
3ohh3HHBeta-secretase 13.4.23.460.443
3tr05GPGuanylate kinase/0.443
3wqmB29Diterpene synthase3.1.7.80.443
4df2FMNNADPH dehydrogenase/0.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1b2lNDCAlcohol dehydrogenase1.1.1.10.442
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.442
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.442
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.442
3af1GDPPantothenate kinase2.7.1.330.442
4bfzZVZPantothenate kinase2.7.1.330.442
1qjfACSIsopenicillin N synthase1.21.3.10.441
2vyqFADFerredoxin--NADP reductase1.18.1.20.441
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.441
3vsxR32Renin3.4.23.150.441
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.441
4nv1TYDFormyl transferase/0.441
4psbGA3Cytokinin-specific binding protein/0.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.441
1dliUDXUDP-glucose 6-dehydrogenase/0.440
1umaIN2Prothrombin3.4.21.50.440
2bjfDXCCholoylglycine hydrolase3.5.1.240.440
2po3T4K4-dehydrase/0.440
3vswR31Renin3.4.23.150.440
3zv7NHGAcetylcholinesterase3.1.1.70.440
4esoNAPPutative oxidoreductase/0.440
4j0v1H7Beta-secretase 13.4.23.460.440