sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.923 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.688 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.666 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.600 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.600 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.594 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.571 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.566 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.551 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.546 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.540 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.539 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.529 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.519 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.518 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.515 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.508 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.501 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.495 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.495 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.486 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.484 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.482 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.480 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.480 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.476 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.475 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.475 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.471 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.470 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.470 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.470 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.465 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.463 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.462 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.462 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.462 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.461 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.460 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.459 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.459 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.459 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.457 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.457 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.457 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.456 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.456 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.454 | |
| 4z0h | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic | 1.2.1.12 | 0.454 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.453 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.453 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.453 | |
| 3zuy | TCH | Transporter | / | 0.453 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.453 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.452 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.451 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.450 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.450 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.450 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2y4g | TIR | TamL | / | 0.449 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.449 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.448 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 3gob | HXX | DdmC | / | 0.448 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.448 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.448 | |
| 3wec | AUI | Cytochrome P450 | / | 0.448 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.448 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.447 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4h6p | FMN | Chromate reductase | / | 0.447 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.447 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.447 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.446 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.446 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.446 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.445 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bxm | IMN | Serum albumin | / | 0.444 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.444 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.444 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.444 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.444 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.444 | |
| 2y3r | TRK | TamL | / | 0.443 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.442 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.442 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.442 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.441 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.441 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.441 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.440 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.440 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.440 |