scPDB - Distribution of Binding site Similarity values of 4igf entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4igf	CHV	Enoyl-acyl carrier reductase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4igf	CHV	Enoyl-acyl carrier reductase	/	1.000
1d7o	TCL	Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	1.3.1.9	0.540
4rlh	0WE	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.506
3fnh	JPJ	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.488
4tzk	641	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.484
2ga2	A19	Methionine aminopeptidase 2	/	0.481
4uwm	FMN	3,6-diketocamphane 1,6 monooxygenase	1.14.13	0.479
2g1o	2IG	Renin	3.4.23.15	0.478
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.477
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.473
3cgt	BCD	Cyclomaltodextrin glucanotransferase	2.4.1.19	0.472
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.471
4kby	C2E	Stimulator of interferon genes protein	/	0.470
5fd8	A5A	Putative carboxypeptidase yocD	/	0.467
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.466
3of2	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.465
1eno	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	1.3.1.9	0.464
1rr6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.461
2ea2	F77	Methionine aminopeptidase 2	/	0.461
4bgi	I4I	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.461
1f20	FAD	Nitric oxide synthase, brain	1.14.13.39	0.460
4dre	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.460
4ey6	GNT	Acetylcholinesterase	3.1.1.7	0.460
2ea4	F79	Methionine aminopeptidase 2	/	0.459
2hr8	SAH	Diphthine synthase	/	0.459
3p3z	P3Z	Putative cytochrome P450	/	0.459
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.458
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
1yw7	A41	Methionine aminopeptidase 2	/	0.458
2xuf	TZ4	Acetylcholinesterase	3.1.1.7	0.457
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.456
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.456
1thn	ADP	Anti-sigma F factor	/	0.455
2b36	5PP	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.455
2b37	8PS	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.455
2g24	7IG	Renin	3.4.23.15	0.455
3v2b	AR6	Poly [ADP-ribose] polymerase 15	2.4.2.30	0.455
4fm8	0UQ	Beta-secretase 1	3.4.23.46	0.455
4g09	0VD	Histidinol dehydrogenase	/	0.455
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.455
4mv1	ADP	Biotin carboxylase	6.3.4.14	0.455
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.455
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.454
1lcb	TMP	Thymidylate synthase	/	0.454
2aq8	NAI	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.454
4trj	665	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.454
3fr2	8CA	Fatty acid-binding protein, adipocyte	/	0.453
4a87	NAR	Major pollen allergen Bet v 1-A	/	0.453
1zpt	NAI	5,10-methylenetetrahydrofolate reductase	1.5.1.20	0.452
3mjh	GTP	Ras-related protein Rab-5A	/	0.452
1amo	FMN	NADPH--cytochrome P450 reductase	/	0.451
1p0p	BCH	Cholinesterase	3.1.1.8	0.451
1xh7	R96	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.451
2g1r	3IG	Renin	3.4.23.15	0.451
2oaz	I96	Methionine aminopeptidase 2	/	0.451
3ehe	NAD	UDP-glucose 4-epimerase (GalE-1)	/	0.451
3mjr	AC2	Deoxycytidine kinase	2.7.1.74	0.451
3otw	COA	Phosphopantetheine adenylyltransferase	/	0.451
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.450
2jn3	JN3	Fatty acid-binding protein, liver	/	0.450
2xug	TZ4	Acetylcholinesterase	3.1.1.7	0.450
2zcv	NDP	Quinone oxidoreductase 2	1.6.5.2	0.450
3sxj	SAM	Putative methyltransferase	/	0.450
3zho	FMN	NAD(P)H dehydrogenase (quinone)	/	0.449
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.449
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.448
1uh5	TCL	Enoyl-ACP reductase	/	0.448
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.448
3nhp	HGZ	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.448
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.448
3v2u	ATP	Protein GAL3	/	0.448
1nuu	NAD	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.447
1yw9	A84	Methionine aminopeptidase 2	/	0.447
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.447
3c16	FOK	Adenylate cyclase type 2	/	0.447
3c16	FOK	Adenylate cyclase type 5	/	0.447
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.447
4kfq	KFQ	Glutamate receptor ionotropic, NMDA 1	/	0.447
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.446
2hun	NAD	336aa long hypothetical dTDP-glucose 4,6-dehydratase	/	0.446
2on6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.446
3h3q	H13	Collagen type IV alpha-3-binding protein	/	0.446
1cjt	FOK	Adenylate cyclase type 2	/	0.445
1cjt	FOK	Adenylate cyclase type 5	/	0.445
1gzu	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	2.7.7.1	0.445
1nja	DCM	Thymidylate synthase	/	0.445
2uxo	TAC	HTH-type transcriptional regulator TtgR	/	0.445
2xuo	TZ4	Acetylcholinesterase	3.1.1.7	0.445
3d91	REM	Renin	3.4.23.15	0.445
1xe6	5FP	Plasmepsin-2	3.4.23.39	0.444
1zsn	TN2	Enoyl-ACP reductase	/	0.444
2e9a	B28	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.444
2fr0	NDP	6-deoxyerythronolide-B synthase EryA1, modules 1 and 2	/	0.444
3pww	ROC	Endothiapepsin	3.4.23.22	0.444
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.444
4yp5	NAP	Nicotinamide-nucleotide adenylyltransferase	2.7.7.1	0.444
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.444
2a1o	CAM	Camphor 5-monooxygenase	1.14.15.1	0.443
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.443
2gvd	FKP	Adenylate cyclase type 2	/	0.443
2gvd	FKP	Adenylate cyclase type 5	/	0.443
2i4q	UA4	Renin	3.4.23.15	0.443
2o2s	TCL	Enoyl-acyl carrier reductase	/	0.443
3iqi	ASN_GLU_ASN_ILE	Cysteine synthase	2.5.1.47	0.443
1bvr	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.442
1xh5	R68	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.442
1zgb	A1E	Acetylcholinesterase	3.1.1.7	0.442
3dmh	SAM	Probable ribosomal RNA small subunit methyltransferase	/	0.442
3qvi	K95	HAP protein	/	0.442
4xo7	ASD	Aldo-keto reductase family 1 member C2	/	0.442
1bil	0IU	Renin	3.4.23.15	0.441
1dnp	MHF	Deoxyribodipyrimidine photo-lyase	4.1.99.3	0.441
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.441
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.441
2op0	7PC	Enoyl-ACP reductase	/	0.441
2rqf	JH3	Hemolymph juvenile hormone binding protein	/	0.441
3gwf	NAP	Cyclohexanone monooxygenase	/	0.441
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.441
4bfw	ZVW	Pantothenate kinase	2.7.1.33	0.441
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.441
4rvf	TYD	D-mycarose 3-C-methyltransferase	/	0.441
1gpn	HUB	Acetylcholinesterase	3.1.1.7	0.440
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.440
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.440
1odc	A8B	Acetylcholinesterase	3.1.1.7	0.440
3apw	DP0	Alpha-1-acid glycoprotein 2	/	0.440
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.440
4j0v	1H7	Beta-secretase 1	3.4.23.46	0.440
4pyo	SAH	Catechol O-methyltransferase	2.1.1.6	0.440