sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.715 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.681 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.677 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.662 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.660 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.658 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.658 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.655 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.653 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.649 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.648 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.643 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.639 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.637 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.633 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.629 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.629 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.628 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.623 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.622 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.614 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.614 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.610 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.597 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.597 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.594 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.594 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.593 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.589 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.584 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.582 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.580 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.577 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.577 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.574 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.571 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.567 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.567 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.566 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.559 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.555 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.537 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.524 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.517 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.514 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.511 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.508 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.506 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.500 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.499 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.487 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.485 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.483 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.479 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.478 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.478 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.474 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.474 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.472 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.472 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.470 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.468 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.468 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.464 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.463 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.460 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.460 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.459 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.458 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.457 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.454 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.454 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.453 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.453 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 2vro | NDP | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | / | 0.450 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.448 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.445 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.445 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.444 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.444 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.443 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.442 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.442 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.441 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.441 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 4hcy | 0YN | Transketolase | / | 0.441 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.440 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.440 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.440 |