Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fmqANPMitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fmqANPMitogen-activated protein kinase 12.7.11.241.000
2y9qANPMitogen-activated protein kinase 12.7.11.240.648
4h3qANPMitogen-activated protein kinase 12.7.11.240.624
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.569
4nifANPMitogen-activated protein kinase 12.7.11.240.566
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.558
3nieANPMitogen-activated protein kinase/0.552
4fv9E71Mitogen-activated protein kinase 12.7.11.240.532
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.531
4s34ANPMitogen-activated protein kinase 12.7.11.240.527
4fv6E57Mitogen-activated protein kinase 12.7.11.240.518
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.513
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.513
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.509
1tvoFRZMitogen-activated protein kinase 12.7.11.240.508
3i60E86Mitogen-activated protein kinase 12.7.11.240.507
3r83Z14Cyclin-dependent kinase 22.7.11.220.507
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.504
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.504
2ojj82AMitogen-activated protein kinase 12.7.11.240.499
2oji33AMitogen-activated protein kinase 12.7.11.240.497
4s33ANPMitogen-activated protein kinase 12.7.11.240.497
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.496
3nynSGVG protein-coupled receptor kinase 62.7.11.160.494
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.493
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.491
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.487
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
4fuxE75Mitogen-activated protein kinase 12.7.11.240.485
4ic7ANPMitogen-activated protein kinase 72.7.11.240.484
4b99R4LMitogen-activated protein kinase 72.7.11.240.483
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.482
4hge15VTyrosine-protein kinase JAK2/0.481
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.480
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.480
4fv8E63Mitogen-activated protein kinase 12.7.11.240.480
2ojg19AMitogen-activated protein kinase 12.7.11.240.479
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.479
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.476
5e8ySTUTGF-beta receptor type-22.7.11.300.476
2z7lS91Mitogen-activated protein kinase 12.7.11.240.475
3zh8C58Protein kinase C iota type2.7.11.130.475
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.475
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.474
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.473
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.473
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
4g6oE28Mitogen-activated protein kinase 12.7.11.240.471
2vtqLZACyclin-dependent kinase 22.7.11.220.470
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.470
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.469
2j0m4STFocal adhesion kinase 12.7.10.20.469
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.469
3nwq2NCGag-Pol polyprotein3.4.23.160.469
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.468
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.467
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.467
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.467
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.466
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.466
3sheI85MAP kinase-activated protein kinase 32.7.11.10.466
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.465
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.465
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.465
3hmm855TGF-beta receptor type-12.7.11.300.465
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.464
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.463
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.462
3qqlX03Cyclin-dependent kinase 22.7.11.220.462
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.462
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
5e92ANPTGF-beta receptor type-22.7.11.300.462
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.461
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3dfcANPDeath-associated protein kinase 12.7.11.10.461
4i5cC5ITyrosine-protein kinase JAK1/0.461
1e9hINRCyclin-dependent kinase 22.7.11.220.460
2c4g514Cyclin-dependent kinase 22.7.11.220.460
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.460
3gu7ADPDeath-associated protein kinase 12.7.11.10.460
3qyw6PBMitogen-activated protein kinase 12.7.11.240.460
3r7yZ04Cyclin-dependent kinase 22.7.11.220.460
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4qnyANPMitogen activated protein kinase, putative/0.460
1eh4IC1Casein kinase I homolog 12.7.11.10.459
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
3gubGUBDeath-associated protein kinase 12.7.11.10.458
3qrtX14Cyclin-dependent kinase 22.7.11.220.458
3rm618ZCyclin-dependent kinase 22.7.11.220.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4fob0USALK tyrosine kinase receptor2.7.10.10.458
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.458
4s32ANPMitogen-activated protein kinase 12.7.11.240.458
1aq1STUCyclin-dependent kinase 22.7.11.220.457
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.457
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.457
1y91CT9Cyclin-dependent kinase 22.7.11.220.457
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.457
3nwxKVSGag-Pol polyprotein3.4.23.160.457
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.457
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.457
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.457
5cnnANPEpidermal growth factor receptor2.7.10.10.457
1bygSTUTyrosine-protein kinase CSK/0.456
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4ivb1J5Tyrosine-protein kinase JAK1/0.456
1oiyN41Cyclin-dependent kinase 22.7.11.220.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.455
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3lltANPProtein serine/threonine kinase-1/0.455
2a4lRRCCyclin-dependent kinase 22.7.11.220.454
3c4xATPRhodopsin kinase/0.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
4fkv61KCyclin-dependent kinase 22.7.11.220.454
4gk3L87Ephrin type-A receptor 32.7.10.10.454
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1py5PY1TGF-beta receptor type-12.7.11.300.453
1w8cN69Cyclin-dependent kinase 22.7.11.220.453
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.453
3gc8B45Mitogen-activated protein kinase 112.7.11.240.453
3s1h56ZCyclin-dependent kinase 22.7.11.220.453
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.453
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.452
2j0lANPFocal adhesion kinase 12.7.10.20.452
3lfqA28Cyclin-dependent kinase 22.7.11.220.452
3rk708ZCyclin-dependent kinase 22.7.11.220.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.452
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2ijmADPFocal adhesion kinase 12.7.10.20.451
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.451
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.451
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.451
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2hog710Serine/threonine-protein kinase Chk12.7.11.10.450
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.450
3lfnA27Cyclin-dependent kinase 22.7.11.220.450
3r9dX6BCyclin-dependent kinase 22.7.11.220.450
3t8oATPRhodopsin kinase/0.450
1hckATPCyclin-dependent kinase 22.7.11.220.449
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.449
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.447
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
3rkb12ZCyclin-dependent kinase 22.7.11.220.447
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.447
3lpbNVBTyrosine-protein kinase JAK2/0.446
3sqq99ZCyclin-dependent kinase 22.7.11.220.446
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.446
4ji91M3Tyrosine-protein kinase JAK2/0.446
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.445
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.445
3s2pPMUCyclin-dependent kinase 22.7.11.220.445
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.445
4nk92K5Fibroblast growth factor receptor 1/0.445
1j39UPGDNA beta-glucosyltransferase/0.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.444
1oitHDTCyclin-dependent kinase 22.7.11.220.444
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.444
2cchATPCyclin-dependent kinase 22.7.11.220.444
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2fvdLIACyclin-dependent kinase 22.7.11.220.444
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.444
3qtrX36Cyclin-dependent kinase 22.7.11.220.444
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.444
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
5e8xSTUTGF-beta receptor type-12.7.11.300.444
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.443
2uzbC75Cyclin-dependent kinase 22.7.11.220.443
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
3ddqRRCCyclin-dependent kinase 22.7.11.220.443
4fv7E94Mitogen-activated protein kinase 12.7.11.240.443
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.443
1h0w207Cyclin-dependent kinase 22.7.11.220.442
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.442
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.442
2wotZZGTGF-beta receptor type-12.7.11.300.442
3iok1P6Tyrosine-protein kinase JAK2/0.442
3teiANPMitogen-activated protein kinase 12.7.11.240.442
4aguD15Cyclin-dependent kinase-like 1/0.442
4cfnJYMCyclin-dependent kinase 22.7.11.220.442
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.442
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4gk4L90Ephrin type-A receptor 32.7.10.10.442
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.441
2vttLZDCyclin-dependent kinase 22.7.11.220.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3qx4X4BCyclin-dependent kinase 22.7.11.220.441
4gt3ATPMitogen-activated protein kinase 12.7.11.240.441
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.440
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.440
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xb7GUIALK tyrosine kinase receptor2.7.10.10.440
3rak03ZCyclin-dependent kinase 22.7.11.220.440
3w32W32Epidermal growth factor receptor2.7.10.10.440
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.440
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.440
4h3pANPMitogen-activated protein kinase 12.7.11.240.440
4hjfC2EGGDEF family protein/0.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440