Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3s4qNK0Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3s4qNK0Mitogen-activated protein kinase 14/1.000
1zyjBI5Mitogen-activated protein kinase 14/0.586
3fklFKLMitogen-activated protein kinase 14/0.584
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.569
3uvqFS8Mitogen-activated protein kinase 14/0.556
3gfeP37Mitogen-activated protein kinase 14/0.549
3mvl38PMitogen-activated protein kinase 14/0.541
4nka2K7Fibroblast growth factor receptor 1/0.540
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.539
3mpt1GKMitogen-activated protein kinase 14/0.539
4kiq1RAMitogen-activated protein kinase 14/0.538
3iphG11Mitogen-activated protein kinase 14/0.532
4f640S8Fibroblast growth factor receptor 1/0.530
3fskRO6Mitogen-activated protein kinase 14/0.528
3nww3NWMitogen-activated protein kinase 14/0.528
4aacAAVMitogen-activated protein kinase 14/0.528
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.527
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.525
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.523
2balPQAMitogen-activated protein kinase 14/0.521
3l8xN4DMitogen-activated protein kinase 14/0.518
4aa4QC0Mitogen-activated protein kinase 14/0.518
3u8w09JMitogen-activated protein kinase 14/0.517
4kip1R9Mitogen-activated protein kinase 14/0.516
3hl7I47Mitogen-activated protein kinase 14/0.515
3hllI45Mitogen-activated protein kinase 14/0.514
3gc9B45Mitogen-activated protein kinase 112.7.11.240.512
2rg5279Mitogen-activated protein kinase 14/0.511
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.510
3fln3FNMitogen-activated protein kinase 14/0.510
3uvp048Mitogen-activated protein kinase 14/0.509
3flyFLYMitogen-activated protein kinase 14/0.508
4eh60ONMitogen-activated protein kinase 14/0.508
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.507
4nks2M2Fibroblast growth factor receptor 1/0.507
1ywrLI9Mitogen-activated protein kinase 14/0.505
2rg6287Mitogen-activated protein kinase 14/0.505
3dt1P40Mitogen-activated protein kinase 14/0.504
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.503
3flsFLSMitogen-activated protein kinase 14/0.503
4aa5NQBMitogen-activated protein kinase 14/0.503
2zb0GK3Mitogen-activated protein kinase 14/0.502
3hp552PMitogen-activated protein kinase 14/0.502
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.502
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.500
4nk92K5Fibroblast growth factor receptor 1/0.500
3itzP66Mitogen-activated protein kinase 14/0.499
4kin1M8Mitogen-activated protein kinase 14/0.499
2zb1GK4Mitogen-activated protein kinase 14/0.497
3fi4FI4Mitogen-activated protein kinase 14/0.497
3roc29AMitogen-activated protein kinase 14/0.497
1ouk084Mitogen-activated protein kinase 14/0.491
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.491
4lopSB4Mitogen-activated protein kinase 14/0.491
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3flwFLWMitogen-activated protein kinase 14/0.490
1m17AQ4Epidermal growth factor receptor2.7.10.10.489
2fgiPD1Fibroblast growth factor receptor 1/0.489
4f630S7Fibroblast growth factor receptor 1/0.489
3gubGUBDeath-associated protein kinase 12.7.11.10.488
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.488
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
1oecAA2Fibroblast growth factor receptor 2/0.484
3mpaSB2Mitogen-activated protein kinase 14/0.484
4gk3L87Ephrin type-A receptor 32.7.10.10.484
4looSB4Mitogen-activated protein kinase 14/0.484
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.482
1m7qDQOMitogen-activated protein kinase 14/0.481
1vjy460TGF-beta receptor type-12.7.11.300.481
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.480
2itzIREEpidermal growth factor receptor2.7.10.10.479
3fmkFMKMitogen-activated protein kinase 14/0.479
3fmn530Mitogen-activated protein kinase 14/0.479
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.479
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.478
4jr3KJREpidermal growth factor receptor2.7.10.10.478
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.477
3fmh533Mitogen-activated protein kinase 14/0.477
4eym0RXMitogen-activated protein kinase 132.7.11.240.476
2hk51BMTyrosine-protein kinase HCK2.7.10.20.474
4gk2L66Ephrin type-A receptor 32.7.10.10.474
3nwxKVSGag-Pol polyprotein3.4.23.160.473
1di9MSQMitogen-activated protein kinase 14/0.472
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.472
2of2547Tyrosine-protein kinase Lck2.7.10.20.471
2of4979Tyrosine-protein kinase Lck2.7.10.20.471
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.471
3flzFLZMitogen-activated protein kinase 14/0.471
3ocgOCGMitogen-activated protein kinase 14/0.471
3vs3VSETyrosine-protein kinase HCK2.7.10.20.471
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.471
4i231C9Epidermal growth factor receptor2.7.10.10.471
4jq8KJ8Epidermal growth factor receptor2.7.10.10.471
1ouy094Mitogen-activated protein kinase 14/0.470
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.470
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
1ove358Mitogen-activated protein kinase 14/0.469
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.469
3uibSB2Putative mitogen-activated protein kinase/0.469
4hvh19RTyrosine-protein kinase JAK32.7.10.20.469
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
3fkoFKOMitogen-activated protein kinase 14/0.468
3js2VM1Fibroblast growth factor receptor 1/0.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
4loqSB4Mitogen-activated protein kinase 14/0.468
4nfn2KCTau-tubulin kinase 12.7.11.10.468
5e8xSTUTGF-beta receptor type-12.7.11.300.468
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.467
3bv3P39Mitogen-activated protein kinase 14/0.467
4yuqKS1Calmodulin-like domain protein kinase/0.467
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
2itqITQEpidermal growth factor receptor2.7.10.10.466
2excJNKMitogen-activated protein kinase 102.7.11.240.465
2qd9LGFMitogen-activated protein kinase 14/0.465
3ds6A17Mitogen-activated protein kinase 14/0.465
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
1wvxBD4Death-associated protein kinase 12.7.11.10.464
4r20AERCytochrome P450 family 17 polypeptide 2/0.464
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.463
2itpAEEEpidermal growth factor receptor2.7.10.10.463
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.463
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.462
2hog710Serine/threonine-protein kinase Chk12.7.11.10.462
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3zewSTUEphrin type-B receptor 42.7.10.10.462
3zh8C58Protein kinase C iota type2.7.11.130.462
4j97ACPFibroblast growth factor receptor 2/0.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.462
1finATPCyclin-dependent kinase 22.7.11.220.461
2vd5BI8Myotonin-protein kinase2.7.11.10.461
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
4anqVGHALK tyrosine kinase receptor2.7.10.10.461
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.461
1zz2B11Mitogen-activated protein kinase 14/0.460
3a62STURibosomal protein S6 kinase beta-12.7.11.10.460
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.460
3zsh469Mitogen-activated protein kinase 14/0.460
4gk4L90Ephrin type-A receptor 32.7.10.10.460
4ic7ANPMitogen-activated protein kinase 72.7.11.240.460
4j55031Gag-Pol polyprotein3.4.23.160.460
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.459
3w2rW2REpidermal growth factor receptor2.7.10.10.459
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.459
4jq7KJQEpidermal growth factor receptor2.7.10.10.459
2eb3ANPEpidermal growth factor receptor2.7.10.10.458
3fc152PMitogen-activated protein kinase 14/0.458
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.457
2i0ePDSProtein kinase C beta type2.7.11.130.457
3el4ROCGag-Pol polyprotein3.4.23.160.457
3obgSB2Mitogen-activated protein kinase 14/0.457
4dce0JFALK tyrosine kinase receptor2.7.10.10.457
4fnzNZFALK tyrosine kinase receptor2.7.10.10.457
4hvg19QTyrosine-protein kinase JAK32.7.10.20.457
4j5j478Gag-Pol polyprotein3.4.23.160.457
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.457
1ida0POGag-Pol polyprotein3.4.23.470.456
1pmn984Mitogen-activated protein kinase 102.7.11.240.456
3gi6D78Gag-Pol polyprotein/0.456
3gxlQIGTGF-beta receptor type-12.7.11.300.456
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.456
3w33W19Epidermal growth factor receptor2.7.10.10.456
4jrvKJVEpidermal growth factor receptor2.7.10.10.456
4qnaX11Serine/threonine-protein kinase 242.7.11.10.456
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.455
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
3hvcGG5Mitogen-activated protein kinase 14/0.455
4bcqTJFCyclin-dependent kinase 22.7.11.220.455
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1hvsA77Gag-Pol polyprotein/0.454
2f3kRO1Protease/0.454
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.454
3nwq2NCGag-Pol polyprotein3.4.23.160.454
4ye3G04Gag-Pol polyprotein3.4.23.160.454
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3em6017Gag-Pol polyprotein3.4.23.160.453
3gc7B45Mitogen-activated protein kinase 14/0.453
4b7sQLECytochrome P450 monooxygenase PikC/0.453
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.453
4j54G52Gag-Pol polyprotein3.4.23.160.453
1bygSTUTyrosine-protein kinase CSK/0.452
1d4lPI9Gag-Pol polyprotein3.4.23.160.452
2qo9ANPEphrin type-A receptor 32.7.10.10.452
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.452
3vjoANPEpidermal growth factor receptor2.7.10.10.452
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4eh70OOMitogen-activated protein kinase 14/0.452
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.451
5f0a1FBcGMP-dependent protein kinase, putative/0.451
1bxoPP7Penicillopepsin-13.4.23.200.450
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2itwITQEpidermal growth factor receptor2.7.10.10.450
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.450
3ekp478Gag-Pol polyprotein3.4.23.160.450
3ttp017Gag-Pol polyprotein3.4.23.160.450
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4ewqMWLMitogen-activated protein kinase 14/0.450
3mvm39PMitogen-activated protein kinase 14/0.449
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.449
5aacVGHALK tyrosine kinase receptor2.7.10.10.449
2qd7065Gag-Pol polyprotein3.4.23.160.448
2qoqANPEphrin type-A receptor 32.7.10.10.448
3bheBZNGag-Pol polyprotein3.4.23.160.448
3ha85JZMitogen-activated protein kinase 14/0.448
3l8p0CEAngiopoietin-1 receptor2.7.10.10.448
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.448
4njt017Protease/0.448
1kzkJE2Gag-Pol polyprotein3.4.23.160.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
1t7i017Gag-Pol polyprotein3.4.23.160.447
1u4dDBQActivated CDC42 kinase 1/0.447
1u54ACPActivated CDC42 kinase 1/0.447
1yw2PGJMitogen-activated protein kinase 14/0.447
3nbwTR4Ketohexokinase/0.447
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.447
3nduROCGag-Pol polyprotein3.4.23.160.447
3qpjN4IGag-Pol polyprotein3.4.23.160.447
4ansVGHALK tyrosine kinase receptor2.7.10.10.447
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.447
4o0wADNAurora kinase A2.7.11.10.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.446
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.446
3kf7L9GMitogen-activated protein kinase 14/0.446
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.446
2aidTHKGag-Pol polyprotein3.4.23.160.445
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2itnANPEpidermal growth factor receptor2.7.10.10.445
2vwz7X6Ephrin type-B receptor 42.7.10.10.445
3ttiKBIMitogen-activated protein kinase 102.7.11.240.445
3w2sW2REpidermal growth factor receptor2.7.10.10.445
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.445
4ih8B43Calmodulin-domain protein kinase 1/0.445
5dr9SKEAurora kinase A2.7.11.10.445
1agwSU2Fibroblast growth factor receptor 1/0.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.444
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
1xkkFMMEpidermal growth factor receptor2.7.10.10.444
2ckeIQUDeath-associated protein kinase 2/0.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2qnqQN3Gag-Pol polyprotein3.4.23.160.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.444
3dcrKVSProtease/0.444
3s85LK0Gag-Pol polyprotein/0.444
4e4m0NHTyrosine-protein kinase JAK2/0.444
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.444
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4o0sADNAurora kinase A2.7.11.10.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1zzlTZYMitogen-activated protein kinase 14/0.443
2h96893Mitogen-activated protein kinase 82.7.11.240.443
2py3ACPFibroblast growth factor receptor 2/0.443
2qd8065Gag-Pol polyprotein3.4.23.160.443
2vx07X7Ephrin type-B receptor 42.7.10.10.443
2vx17X8Ephrin type-B receptor 42.7.10.10.443
2xclANPPhosphoribosylamine--glycine ligase/0.443
3ac1KZITyrosine-protein kinase Lck2.7.10.20.443
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.443
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.443
4cd2FOLDihydrofolate reductase1.5.1.30.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.442
2f8g017Gag-Pol polyprotein3.4.23.160.442
2fdd385Pol protein/0.442
2nnpROCProtease/0.442
2r43G3GGag-Pol polyprotein3.4.23.160.442
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.442
2zybKSLTyrosine-protein kinase Lck2.7.10.20.442
3bgbLJGGag-Pol polyprotein3.4.23.160.442
3fknFKNMitogen-activated protein kinase 14/0.442
3nu3478Gag-Pol polyprotein3.4.23.160.442
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
4cd0AWJALK tyrosine kinase receptor2.7.10.10.442
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4hdfG52Gag-Pol polyprotein3.4.23.160.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1gih1PUCyclin-dependent kinase 22.7.11.220.441
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.441
1u3cFADCryptochrome-1/0.441
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.441
3q5iANPProtein kinase, putative/0.441
3rinI2OMitogen-activated protein kinase 14/0.441
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.441
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.441
1vikBAYGag-Pol polyprotein/0.440
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.440
3bx5304Mitogen-activated protein kinase 14/0.440
3fmmXI2Mitogen-activated protein kinase 14/0.440
3igoANPCalmodulin-domain protein kinase 1, putative/0.440
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.440
3nuo478Gag-Pol polyprotein3.4.23.160.440
3q92XNBKetohexokinase/0.440
3qp0NI8Gag-Pol polyprotein3.4.23.160.440
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.440
4c02TAKActivin receptor type-12.7.11.300.440
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440