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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3s3gTLTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3s3gTLTAldose reductase1.1.1.211.000
3v35NTIAldose reductase1.1.1.210.705
2pdwFIDAldose reductase1.1.1.210.668
2f2kTGGAldose reductase1.1.1.210.663
1pwmFIDAldose reductase1.1.1.210.652
3u2cSUZAldose reductase1.1.1.210.641
1ef3FIDAldose reductase1.1.1.210.631
2inzOHPAldose reductase1.1.1.210.630
2pdyFIDAldose reductase1.1.1.210.628
2is72CLAldose reductase1.1.1.210.619
3p2vDOYAldose reductase1.1.1.210.612
2pdj393Aldose reductase1.1.1.210.600
2nvcITAAldose reductase1.1.1.210.597
4gabFIDAldo-keto reductase family 1 member B101.1.10.595
2pdh47DAldose reductase1.1.1.210.590
1ekoI84Aldose reductase1.1.1.210.586
2pdkSBIAldose reductase1.1.1.210.585
2pd9FIDAldose reductase1.1.1.210.584
2agtFIDAldose reductase1.1.1.210.576
1ah0SBIAldose reductase1.1.1.210.562
4wevSUZAldo-keto reductase family 1 member B101.1.10.560
2iqdLPAAldose reductase1.1.1.210.557
2hvnZSTAldose reductase1.1.1.210.554
1el3I84Aldose reductase1.1.1.210.549
2pdu393Aldose reductase1.1.1.210.549
2fz8ZSTAldose reductase1.1.1.210.545
2hvoZSTAldose reductase1.1.1.210.533
3ghsLDTAldose reductase1.1.1.210.533
3ghrLDTAldose reductase1.1.1.210.531
5liu388Aldo-keto reductase family 1 member B101.1.10.528
2pdp393Aldose reductase1.1.1.210.523
2iki388Aldose reductase1.1.1.210.520
3lboLDTAldose reductase1.1.1.210.520
3mb9ZSTAldose reductase1.1.1.210.517
2ikj393Aldose reductase1.1.1.210.516
4ga8SBIAldo-keto reductase family 1 member B101.1.10.514
2i17LDTAldose reductase1.1.1.210.513
2pdlTOLAldose reductase1.1.1.210.512
3m64393Aldose reductase1.1.1.210.511
4fam0SZAldo-keto reductase family 1 member C3/0.511
2fzdTOLAldose reductase1.1.1.210.510
2i16LDTAldose reductase1.1.1.210.505
1z3n3NAAldose reductase1.1.1.210.504
2fzbTOLAldose reductase1.1.1.210.503
2pdxZSTAldose reductase1.1.1.210.502
2duzZSTAldose reductase1.1.1.210.501
2pb1NFGGlucan 1,3-beta-glucosidase/0.499
3ghuLDTAldose reductase1.1.1.210.497
4gca2X9Aldose reductase1.1.1.210.497
3m4h388Aldose reductase1.1.1.210.495
2pzn393Aldose reductase1.1.1.210.494
1ah3TOLAldose reductase1.1.1.210.493
2pdbZSTAldose reductase1.1.1.210.493
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.20.493
3ld5LDTAldose reductase1.1.1.210.493
3lqlLDTAldose reductase1.1.1.210.493
2dv0ZSTAldose reductase1.1.1.210.492
1ry0PG2Aldo-keto reductase family 1 member C3/0.491
2pdn47DAldose reductase1.1.1.210.487
1us0LDTAldose reductase1.1.1.210.486
1pwlBFIAldose reductase1.1.1.210.485
3lz5LDTAldose reductase1.1.1.210.485
1t40ID5Aldose reductase1.1.1.210.483
1z8962PAldose reductase1.1.1.210.482
2ipw2CLAldose reductase1.1.1.210.482
4mqt2CUMuscarinic acetylcholine receptor M2/0.482
1ieiZESAldose reductase1.1.1.210.481
2fz9ZSTAldose reductase1.1.1.210.481
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.481
3g5eQ74Aldose reductase1.1.1.210.481
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.480
1ry8RUTAldo-keto reductase family 1 member C3/0.479
2pd5ZSTAldose reductase1.1.1.210.479
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.478
4bfwZVWPantothenate kinase2.7.1.330.477
1rxjBNIStreptavidin/0.475
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.475
2cbqTH2Neocarzinostatin/0.474
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.474
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.472
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.472
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.471
2qxwLDTAldose reductase1.1.1.210.470
3f3y4OABile salt sulfotransferase2.8.2.140.470
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.470
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.469
4yu153NAldose reductase1.1.1.210.469
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.468
2aot2PMHistamine N-methyltransferase2.1.1.80.468
2hv5ZSTAldose reductase1.1.1.210.468
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.468
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.468
3sfy3FYUncharacterized protein/0.468
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.468
3lenZSTAldose reductase1.1.1.210.467
1zgcA2EAcetylcholinesterase3.1.1.70.466
2duxZSTAldose reductase1.1.1.210.466
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
3r8gIZPAldo-keto reductase family 1 member C3/0.464
3zkuHCVIsopenicillin N synthase1.21.3.10.464
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.463
2xlpNAPPutative flavin-containing monooxygenase/0.462
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
1t41ID5Aldose reductase1.1.1.210.461
2pdc393Aldose reductase1.1.1.210.461
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.461
3mc5393Aldose reductase1.1.1.210.461
3r8hZOMAldo-keto reductase family 1 member C3/0.461
4bfuZVUPantothenate kinase2.7.1.330.461
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.460
1nbhSAMGlycine N-methyltransferase2.1.1.200.460
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.460
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3q9bB3NAcetylpolyamine amidohydrolase/0.460
4dbuBT9Aldo-keto reductase family 1 member C3/0.460
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.459
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.459
3n0hTOPDihydrofolate reductase1.5.1.30.459
1hfrMOTDihydrofolate reductase1.5.1.30.458
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.458
2xltNA0Putative flavin-containing monooxygenase/0.458
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.458
5dsg0HKMuscarinic acetylcholine receptor M4/0.458
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.457
1h22E10Acetylcholinesterase3.1.1.70.457
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.457
3af1GDPPantothenate kinase2.7.1.330.457
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.457
2j3qTFLAcetylcholinesterase3.1.1.70.456
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.456
1sjwNGVNogalonic acid methyl ester cyclase/0.455
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2hzqSTRApolipoprotein D/0.455
2nvdITBAldose reductase1.1.1.210.455
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.455
1odcA8BAcetylcholinesterase3.1.1.70.454
1p0pBCHCholinesterase3.1.1.80.454
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.454
2w3mFOLDihydrofolate reductase1.5.1.30.454
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.454
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3gyf51PDihydrofolate reductase1.5.1.30.454
3ug8IMNAldo-keto reductase family 1 member C3/0.454
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.454
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.454
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.453
1s3uTQDDihydrofolate reductase1.5.1.30.453
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2bjsACVIsopenicillin N synthase1.21.3.10.453
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.453
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4yfy0FXVioF/0.453
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1w4lGL8Acetylcholinesterase3.1.1.70.452
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1z71L17Prothrombin3.4.21.50.452
2ckmAA7Acetylcholinesterase3.1.1.70.452
2jl1NAPTriphenylmethane reductase/0.452
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.452
4dyp0MSNucleoprotein/0.452
4dz5NAPAldo-keto reductase family 1 member C3/0.452
4hmn16JAldo-keto reductase family 1 member C3/0.452
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2f3815MAldo-keto reductase family 1 member C3/0.451
2ikhLITAldose reductase1.1.1.210.451
2ycnP61Tyrosine phenol-lyase4.1.99.20.451
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.451
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
3ny9JSZBeta-2 adrenergic receptor/0.451
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.450
1zq5E04Aldo-keto reductase family 1 member C3/0.450
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.450
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.450
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.450
4m6kFOLDihydrofolate reductase1.5.1.30.450
2ycxP32Beta-1 adrenergic receptor/0.450
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1u70MTXDihydrofolate reductase1.5.1.30.449
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.449
3klbFMNUncharacterized protein/0.449
4bfsZVSPantothenate kinase2.7.1.330.449
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.449
1dx6GNTAcetylcholinesterase3.1.1.70.448
2dhfDZFDihydrofolate reductase1.5.1.30.448
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3rl45GPMetallophosphoesterase MPPED23.10.448
1kmsLIHDihydrofolate reductase1.5.1.30.447
1xf0ASDAldo-keto reductase family 1 member C3/0.447
2gyuHI6Acetylcholinesterase3.1.1.70.447
2xi4AFTAcetylcholinesterase3.1.1.70.447
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.447
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.447
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.447
2pdq47DAldose reductase1.1.1.210.446
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1blzACVIsopenicillin N synthase1.21.3.10.445
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.445
1ohjCOPDihydrofolate reductase1.5.1.30.445
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
2zsbADPPantothenate kinase2.7.1.330.445
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4kfjFOLDihydrofolate reductase1.5.1.30.445
1lkeDOGBilin-binding protein/0.444
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
4c49HCYCorticosteroid-binding globulin/0.444
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.444
4lcw1VYMajor histocompatibility complex class I-related gene protein/0.444
3d4sTIMBeta-2 adrenergic receptor/0.444
1jumBERHTH-type transcriptional regulator QacR/0.443
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.443
3ugrIMNAldo-keto reductase family 1 member C3/0.443
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.443
1eveE20Acetylcholinesterase3.1.1.70.442
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1zuaTOLAldo-keto reductase family 1 member B101.1.10.442
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.442
3aezGDPPantothenate kinase2.7.1.330.442
4bftZVTPantothenate kinase2.7.1.330.442
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
4nv10FXFormyl transferase/0.442
4phlPILPhosphodiesterase/0.442
4xo7ASDAldo-keto reductase family 1 member C2/0.442
5jr34MUCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.442
5d6lCAUBeta-2 adrenergic receptor/0.442
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1zgbA1EAcetylcholinesterase3.1.1.70.441
2f99AKVAklanonic acid methyl ester cyclase AcmA5.5.1.230.441
3r6iJMSAldo-keto reductase family 1 member C3/0.441
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.441
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4qa2SHHHistone deacetylase 83.5.1.980.441
1w6jR71Lanosterol synthase5.4.99.70.440
2b8jADNClass B acid phosphatase3.1.3.20.440
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.440
2xlrFADPutative flavin-containing monooxygenase/0.440
2xufTZ4Acetylcholinesterase3.1.1.70.440
2xukTZ5Acetylcholinesterase3.1.1.70.440
3nu03TUDihydrofolate reductase1.5.1.30.440
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.440