sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.769 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.744 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.717 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.714 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.707 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.682 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.681 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.677 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.665 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.659 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.654 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.647 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.627 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.620 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.611 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.601 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.597 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.593 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.593 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.584 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.584 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.583 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.581 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.580 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.580 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.579 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.579 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.576 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.575 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.575 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.573 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.568 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.567 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.562 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.558 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.558 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.552 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.552 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.546 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.539 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.538 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.516 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.515 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.515 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.511 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.510 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.493 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.492 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.484 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.482 | |
| 1lke | DOG | Bilin-binding protein | / | 0.481 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.478 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.474 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.472 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.468 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.468 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.466 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.464 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.464 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.463 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.462 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.460 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.458 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.458 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.456 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.456 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.455 | |
| 4phl | PIL | Phosphodiesterase | / | 0.455 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.453 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.451 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.450 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.450 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.450 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.449 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.448 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.448 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.448 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.448 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.447 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.445 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.443 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.440 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.440 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.440 |