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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gegNADShort-chain dehydrogenase/reductase SDR

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gegNADShort-chain dehydrogenase/reductase SDR/1.000
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.581
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.557
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.542
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.528
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.520
1zemNADXylitol dehydrogenase/0.519
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.516
5jlaNADPutative short-chain dehydrogenase/reductase/0.513
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.503
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.502
3toxNAPPutative oxidoreductase/0.501
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.499
4fn4NADShort chain dehydrogenase/0.499
3lqfNADGalactitol dehydrogenase/0.497
4qecNAPElxO/0.496
1ipeNDPTropinone reductase 21.1.1.2360.494
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.494
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.493
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.493
1g6kNADGlucose 1-dehydrogenase1.1.1.470.491
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.491
1gcoNADGlucose 1-dehydrogenase1.1.1.470.490
1iy8NADLevodione reductase/0.489
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.489
4gh5NADShort-chain dehydrogenase/reductase SDR/0.488
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.487
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.487
1g1aNADdTDP-glucose 4,6-dehydratase/0.486
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.484
1x7hNDPPutative ketoacyl reductase1.3.10.484
3wdsNADNADH-dependent quinuclidinone reductase/0.484
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.483
4hwkNAPSepiapterin reductase1.1.1.1530.481
1ae1NAPTropinone reductase 1/0.479
3r3sNADPutative oxidoreductase/0.479
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.479
5jydNADShort chain dehydrogenase/0.479
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.477
4esoNAPPutative oxidoreductase/0.477
3ak4NADNADH-dependent quinuclidinone reductase/0.476
3s55NADPutative short-chain dehydrogenase/reductase/0.476
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.474
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.474
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.474
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.473
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.473
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.472
4j7xNAPSepiapterin reductase1.1.1.1530.472
4qedNAPElxO/0.472
4yagNAIC alpha-dehydrogenase/0.472
1axeNADAlcohol dehydrogenase E chain1.1.1.10.471
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.471
1w4zNAPPutative ketoacyl reductase1.3.10.471
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.471
5lc1NADL-threonine 3-dehydrogenase/0.471
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.470
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.469
4j7uNAPSepiapterin reductase1.1.1.1530.469
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.468
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.467
2jahNDPClavaldehyde dehydrogenase/0.467
3d3wNAPL-xylulose reductase1.1.1.100.467
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.467
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.467
4bmvNAPShort-chain dehydrogenase/0.465
5ig2NADShort-chain dehydrogenase/reductase SDR/0.464
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.463
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.462
1kolNADGlutathione-independent formaldehyde dehydrogenase/0.462
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.462
3ai3NDPNADPH-sorbose reductase/0.462
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.462
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.462
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.461
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
1xg5NAPDehydrogenase/reductase SDR family member 11/0.460
2dteNAIGlucose 1-dehydrogenase related protein/0.460
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.460
3f1kNAPUncharacterized oxidoreductase YciK10.460
4egbNADdTDP-glucose 4,6-dehydratase/0.460
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.459
4b79NADProbable short-chain dehydrogenase/0.459
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.459
4yaiNAIC alpha-dehydrogenase/0.459
1f8fNADBenzyl alcohol dehydrogenase/0.458
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.458
3rj9NADAlcohol dehydrogenase1.1.1.10.458
4idgNADPutative UDP-glucose 4-epimerase/0.458
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.458
1h2bNAJNAD-dependent alcohol dehydrogenase/0.457
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.457
3ai2NDPNADPH-sorbose reductase/0.457
3bmoNAPPteridine reductase/0.457
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.457
4gl4NAIAlcohol dehydrogenase class-3/0.456
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.456
3w8eNAD3-hydroxybutyrate dehydrogenase/0.455
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.455
1geeNADGlucose 1-dehydrogenase1.1.1.470.454
3jv7NADSecondary alcohol dehydrogenase/0.454
5idwNAPShort-chain dehydrogenase/reductase SDR/0.454
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
4nbwNADShort-chain dehydrogenase/reductase SDR/0.453
1hldNADAlcohol dehydrogenase E chain1.1.1.10.452
1x7gNAPPutative ketoacyl reductase1.3.10.452
3vdqNAD3-hydroxybutyrate dehydrogenase/0.452
1e3lNADAlcohol dehydrogenase 41.1.1.10.451
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.451
3tscNADUncharacterized protein/0.450
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.449
3sx2NADUncharacterized protein/0.448
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.448
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
3p19NDPPutative blue fluorescent protein/0.447
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.447
5kj6NAJAlcohol dehydrogenase E chain1.1.1.10.447
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.446
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.446
4cpdNADAlcohol dehydrogenase/0.446
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.446
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.445
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.445
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.445
2wdzNADGalactitol dehydrogenase/0.445
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.445
3u4cNDPNADPH-dependent reductase BacG/0.445
1hetNADAlcohol dehydrogenase E chain1.1.1.10.444
1ma0NADAlcohol dehydrogenase class-31.1.1.10.444
1rwbNADGlucose 1-dehydrogenase1.1.1.470.444
1sowNADL-lactate dehydrogenase1.1.1.270.444
2p5uNADUDP-glucose 4-epimerase/0.444
1snyNAPLD36273p/0.443
3a1nNADNDP-sugar epimerase/0.443
3p8z36AGenome polyprotein2.1.1.560.443
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.443
1hszNADAlcohol dehydrogenase 1B1.1.1.10.442
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.441
1mg5NAIAlcohol dehydrogenase1.1.1.10.441
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.441
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
2wsbNADGalactitol dehydrogenase/0.440
3a4vNADNDP-sugar epimerase/0.440
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.440
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.440
4jjiNADAlcohol dehydrogenase class-3/0.440
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.440