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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3d4pNADL-lactate dehydrogenase 11.1.1.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3d4pNADL-lactate dehydrogenase 11.1.1.271.000
2x0iNAIMalate dehydrogenase/0.556
4i1iNADMalate dehydrogenase/0.541
2aa3AP0L-lactate dehydrogenase/0.535
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.529
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.526
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.525
1ez4NADL-lactate dehydrogenase1.1.1.270.519
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.514
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.508
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.507
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.499
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.498
1uxjNADMalate dehydrogenase/0.488
2a94AP0L-lactate dehydrogenase1.1.1.270.488
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.484
4g3jVNTLanosterol 14-alpha-demethylase/0.484
5a1tNAIL-lactate dehydrogenase/0.483
3wswNADL-lactate dehydrogenase/0.482
1t2cNAIL-lactate dehydrogenase1.1.1.270.481
1nzdUPGDNA beta-glucosyltransferase/0.480
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.478
4ipw1G7Mycocyclosin synthase1.14.21.90.478
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.477
3gw9VNILanosterol 14-alpha-demethylase/0.475
2ldbNADL-lactate dehydrogenase1.1.1.270.474
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.472
3m6iNADL-arabinitol 4-dehydrogenase1.1.1.120.470
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.468
4ajn88VL-lactate dehydrogenase A chain1.1.1.270.468
1e3eNAIAlcohol dehydrogenase 41.1.1.10.466
3lqfNADGalactitol dehydrogenase/0.466
1uxkNADMalate dehydrogenase/0.465
2ejzSAHDiphthine synthase/0.465
3to6LYS_CMCHistone acetyltransferase ESA1/0.465
1tehNADAlcohol dehydrogenase class-31.1.1.10.464
3p62FMNPentaerythritol tetranitrate reductase/0.464
4yaoFMNNADPH--cytochrome P450 reductase/0.464
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
2gjlFMNNitronate monooxygenase1.13.12.160.463
2pwcG3GGag-Pol polyprotein3.4.23.160.463
3h3jNADL-lactate dehydrogenase 11.1.1.270.463
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.463
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.462
1guyNADMalate dehydrogenase/0.461
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1w6hTITPlasmepsin-23.4.23.390.460
3mk6ACOPantothenate kinase 32.7.1.330.460
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.460
1emdNADMalate dehydrogenase/0.459
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.459
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.458
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
3s1dZIRCytokinin dehydrogenase 11.5.99.120.457
4gddNAIUDP-galactopyranose mutase/0.457
4ambDUDPutative glycosyl transferase/0.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
4xguADPPutative pachytene checkpoint protein 2/0.456
2gevCOKPantothenate kinase2.7.1.330.455
3gfbNADL-threonine 3-dehydrogenase/0.455
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.455
1xe55FEPlasmepsin-23.4.23.390.454
1xe65FPPlasmepsin-23.4.23.390.454
3a3gDLZLumazine protein/0.454
1gv0NADMalate dehydrogenase/0.453
3b6zCO7Enoyl reductase LovC10.453
4gl4NAIAlcohol dehydrogenase class-3/0.453
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.452
1msmJE2Gag-Pol polyprotein3.4.23.160.451
2gv8NDPThiol-specific monooxygenase1.14.130.451
2q5g1FAPeroxisome proliferator-activated receptor delta/0.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.451
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.451
4bfsZVSPantothenate kinase2.7.1.330.451
4g7gVFVLanosterol 14-alpha-demethylase/0.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
1b8vNADMalate dehydrogenase/0.450
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2iko7IGRenin3.4.23.150.450
2uxoTACHTH-type transcriptional regulator TtgR/0.450
1ur5NADMalate dehydrogenase/0.449
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.448
3tjzGNPADP-ribosylation factor 1/0.447
4rosAPRMalate dehydrogenase/0.447
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.447
5jscFADPutative acyl-CoA dehydrogenase/0.447
1fm4DXCMajor pollen allergen Bet v 1-L/0.446
2i7pACOPantothenate kinase 32.7.1.330.446
3e8xNAPBH1520 protein/0.446
4bfvZVVPantothenate kinase2.7.1.330.446
1xddAAYIntegrin alpha-L/0.445
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.445
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.445
4m83ERYOleandomycin glycosyltransferase2.4.10.445
1ib6NADMalate dehydrogenase/0.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
3zuyTCHTransporter/0.444
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.444
4jjiNADAlcohol dehydrogenase class-3/0.444
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.444
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.444
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
1me7MOAInosine-5'-monophosphate dehydrogenase/0.443
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3bg7FADPyranose 2-oxidase/0.443
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.443
4b4vL34Bifunctional protein FolD/0.443
1mp0NADAlcohol dehydrogenase class-31.1.1.10.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.442
3gvhNADMalate dehydrogenase/0.442
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.442
4a83DXCMajor pollen allergen Bet v 1-A/0.442
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
1u3dFADCryptochrome-1/0.441
2iypNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.441
2r43G3GGag-Pol polyprotein3.4.23.160.441
3hl0NADMaleylacetate reductase/0.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4irnFADAnaB/0.441
3c1y2BADNA integrity scanning protein DisA/0.440
3ensENSCoagulation factor X3.4.21.60.440
3h3r14HCollagen type IV alpha-3-binding protein/0.440
3kkzSAMUncharacterized protein/0.440
4dc0NDPPutative ketoacyl reductase1.3.10.440
4gdcNDPUDP-galactopyranose mutase/0.440
4i9h1E4L-lactate dehydrogenase A chain1.1.1.270.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.440