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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2rehFADNitroalkane oxidase1.7.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2rehFADNitroalkane oxidase1.7.3.11.000
4iae1DXAlr2278 protein/0.493
2vcmM11Isopenicillin N synthase1.21.3.10.492
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.487
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.485
1bk0ACVIsopenicillin N synthase1.21.3.10.484
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.481
2iviACWIsopenicillin N synthase1.21.3.10.481
2c20NADUDP-glucose 4-epimerase/0.479
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.478
2rqfJH3Hemolymph juvenile hormone binding protein/0.478
1qiqACCIsopenicillin N synthase1.21.3.10.477
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.476
3zoiM2WIsopenicillin N synthase1.21.3.10.476
4bfuZVUPantothenate kinase2.7.1.330.476
4bfzZVZPantothenate kinase2.7.1.330.476
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
4b4vL34Bifunctional protein FolD/0.472
2ejzSAHDiphthine synthase/0.471
3qeoLLTDeoxycytidine kinase2.7.1.740.471
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.470
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.469
3gncQQQGlutaryl-CoA dehydrogenase/0.469
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
1zdwFLVPrenyltransferase/0.468
3nmpPYVAbscisic acid receptor PYL2/0.468
3nx2FERFerulic acid decarboxylase/0.468
1obnASVIsopenicillin N synthase1.21.3.10.467
2huxSAHDiphthine synthase/0.467
2vbpVB1Isopenicillin N synthase1.21.3.10.467
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.467
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
2jb4A14Isopenicillin N synthase1.21.3.10.465
2uxoTACHTH-type transcriptional regulator TtgR/0.465
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.465
1hb3SCVIsopenicillin N synthase1.21.3.10.464
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.463
4bb3KKAIsopenicillin N synthase1.21.3.10.462
5irnADPNucleotide binding oligomerization domain containing 2/0.462
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.461
1hfqMOTDihydrofolate reductase1.5.1.30.461
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.461
2bxmIMNSerum albumin/0.461
2zbaZBATrichothecene 3-O-acetyltransferase/0.461
3fznD7KBenzoylformate decarboxylase4.1.1.70.461
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.461
4zj8SUVOrexin receptor type 1/0.461
1ay0TPPTransketolase 12.2.1.10.460
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.460
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4e470N6Histone-lysine N-methyltransferase SETD72.1.1.430.460
4g3jVNTLanosterol 14-alpha-demethylase/0.460
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.460
1qjfACSIsopenicillin N synthase1.21.3.10.459
2ylzFADPhenylacetone monooxygenase1.14.13.920.459
4egbNADdTDP-glucose 4,6-dehydratase/0.459
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.458
1xddAAYIntegrin alpha-L/0.458
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.458
2rlcCHDCholoylglycine hydrolase3.5.1.240.458
2x7hPFNProstaglandin reductase 310.458
2xvfFADPutative flavin-containing monooxygenase/0.458
2ym2FADPhenylacetone monooxygenase1.14.13.920.458
3ixp834Ecdysone receptor/0.457
4l0qNADAlcohol dehydrogenase class-3/0.457
5dozNDPJamJ/0.457
1yqzCOACoenzyme A disulfide reductase/0.456
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.456
2bjfDXCCholoylglycine hydrolase3.5.1.240.455
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.455
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.455
2lfoGCHFatty acid-binding protein, liver/0.455
3gnvXNZGenome polyprotein2.7.7.480.455
3h3t16HCollagen type IV alpha-3-binding protein/0.455
4cdmFO1Deoxyribodipyrimidine photolyase/0.455
4m83ERYOleandomycin glycosyltransferase2.4.10.455
1towCRZFatty acid-binding protein, adipocyte/0.454
2nr4FMNConserved protein/0.454
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.454
2xlrFADPutative flavin-containing monooxygenase/0.454
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
1s7gNADNAD-dependent protein deacylase 2/0.453
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.453
2ed3SAHDiphthine synthase/0.453
2gblATPCircadian clock protein kinase KaiC2.7.11.10.453
2qw034Z4-chlorobenzoyl CoA ligase/0.453
4jlm1NNDeoxycytidine kinase2.7.1.740.453
1c7oPPGHemolysin/0.452
1cs4FOKAdenylate cyclase type 2/0.452
1cs4FOKAdenylate cyclase type 5/0.452
2bu9HFVIsopenicillin N synthase1.21.3.10.452
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.452
2vbdV10Isopenicillin N synthase1.21.3.10.452
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3mjrAC2Deoxycytidine kinase2.7.1.740.452
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.452
5dp2NAPCurF/0.452
1cjkFOKAdenylate cyclase type 2/0.451
1cjkFOKAdenylate cyclase type 5/0.451
1hb1OCVIsopenicillin N synthase1.21.3.10.451
1p8dCO1Oxysterols receptor LXR-beta/0.451
2a5kAZPReplicase polyprotein 1ab3.4.220.451
2rhrEMOPutative ketoacyl reductase1.3.10.451
4b4w9L9Bifunctional protein FolD/0.451
4bftZVTPantothenate kinase2.7.1.330.451
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4q0kGA3Phytohormone-binding protein/0.451
2e8qSAHDiphthine synthase/0.450
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.450
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4iah1DXAlr2278 protein/0.450
1toiHCIAspartate aminotransferase2.6.1.10.449
2xviFADPutative flavin-containing monooxygenase/0.449
3eksCY9Actin-5C/0.449
3hk1B64Fatty acid-binding protein, adipocyte/0.449
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.449
4bfxZVXPantothenate kinase2.7.1.330.449
4boeCLRJapanin/0.449
4enhFVXCholesterol 24-hydroxylase/0.449
4g95OAGDihydrofolate reductase1.5.1.30.449
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.449
1g63FMNEpidermin decarboxylase4.1.10.448
1rszDIHPurine nucleoside phosphorylase2.4.2.10.448
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2wo7ASVIsopenicillin N synthase1.21.3.10.448
2xvq9DSSerum albumin/0.448
3dd125DGlycogen phosphorylase, liver form2.4.1.10.448
3tk3CPZCytochrome P450 2B41.14.14.10.448
3uyk0CXProbable NDP-rhamnosyltransferase/0.448
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.448
1d3pBT3Prothrombin3.4.21.50.447
2eh5SAHDiphthine synthase/0.447
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.447
2iyaZIOOleandomycin glycosyltransferase/0.447
3fr4F8AFatty acid-binding protein, adipocyte/0.447
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3mauEXTPutative sphingosine-1-phosphate lyase/0.447
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4a83DXCMajor pollen allergen Bet v 1-A/0.447
5c1mCLRMu-type opioid receptor/0.447
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.447
1fm4DXCMajor pollen allergen Bet v 1-L/0.446
1qorNDPQuinone oxidoreductase 1/0.446
1wngSAHDiphthine synthase/0.446
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
2po7CHDFerrochelatase, mitochondrial4.99.1.10.446
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
2w9hTOPDihydrofolate reductase1.5.1.30.446
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.446
3k0fATPCircadian clock protein kinase KaiC2.7.11.10.446
4iaq2GM5-hydroxytryptamine receptor 1B/0.446
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.446
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.446
1gnwGTXGlutathione S-transferase F22.5.1.180.445
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.445
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.445
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.445
3h3qH13Collagen type IV alpha-3-binding protein/0.445
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
4c73TLH3-oxoacyl-ACP synthase/0.445
4cukNAID-lactate dehydrogenase/0.445
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.445
1dhfFOLDihydrofolate reductase1.5.1.30.444
1jkx138Phosphoribosylglycinamide formyltransferase/0.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.444
4eqrCOACoenzyme A disulfide reductase/0.444
4n1gCEIObelin/0.444
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.444
1dr3TAPDihydrofolate reductase1.5.1.30.443
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.443
1me6IVSPlasmepsin-23.4.23.390.443
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.443
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.443
2gv8NDPThiol-specific monooxygenase1.14.130.443
2pchSAHDiphthine synthase/0.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.443
2wpxACOOrf14/0.443
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4a81DXCMajor pollen allergen Bet v 1-A/0.443
4fhf0TTSpore photoproduct lyase/0.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
1kzjCB3Thymidylate synthase/0.442
1w0kADPATP synthase subunit alpha, mitochondrial/0.442
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2dv4SAHDiphthine synthase/0.442
2flhZEACytokinin-specific binding protein/0.442
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.442
2w6pOA4Biotin carboxylase6.3.4.140.442
2yoj8Y6Genome polyprotein2.7.7.480.442
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.442
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.442
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.441
1v453DGPurine nucleoside phosphorylase2.4.2.10.441
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.441
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.441
2uxpCLMHTH-type transcriptional regulator TtgR/0.441
3c3xNAPEugenol synthase 11.1.1.3180.441
3dvlATPCircadian clock protein kinase KaiC2.7.11.10.441
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.441
3r5zF42Uncharacterized protein/0.441
3tfyCOAN-alpha-acetyltransferase 502.3.10.441
4fgh0U6Dihydrofolate reductase1.5.1.30.441
1dr2TAPDihydrofolate reductase1.5.1.30.440
1ypeUIPProthrombin3.4.21.50.440
2eglSAHDiphthine synthase/0.440
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.440
2fonFADAcyl-coenzyme A oxidase/0.440
3br3ETHTH-type transcriptional regulator QacR/0.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3qe2FMNNADPH--cytochrome P450 reductase/0.440
3wv9FEGHmd co-occurring protein HcgE/0.440
4tldAGSCircadian clock protein kinase KaiC2.7.11.10.440
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440