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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2owuSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2owuSAHDiphthine synthase/1.000
2eeqSAHDiphthine synthase/0.860
2e17SAHDiphthine synthase/0.794
2z6rSAHDiphthine synthase/0.778
2e07SAHDiphthine synthase/0.767
2p6iSAHDiphthine synthase/0.753
2e15SAHDiphthine synthase/0.751
2dsiSAHDiphthine synthase/0.744
2e08SAHDiphthine synthase/0.723
2p2xSAHDiphthine synthase/0.723
2ek2SAHDiphthine synthase/0.717
2hutSAHDiphthine synthase/0.714
2ek3SAHDiphthine synthase/0.709
2egbSAHDiphthine synthase/0.705
2ejjSAHDiphthine synthase/0.700
2p5fSAHDiphthine synthase/0.695
2ed5SAHDiphthine synthase/0.693
2p5cSAHDiphthine synthase/0.692
2e8hSAHDiphthine synthase/0.691
2dshSAHDiphthine synthase/0.690
1wngSAHDiphthine synthase/0.689
2egsSAHDiphthine synthase/0.689
2dv4SAHDiphthine synthase/0.688
2huqSAHDiphthine synthase/0.686
2dv7SAHDiphthine synthase/0.685
2owkSAHDiphthine synthase/0.684
2eniSAHDiphthine synthase/0.674
2p6kSAHDiphthine synthase/0.671
2dekSAHDiphthine synthase/0.665
2dv5SAHDiphthine synthase/0.665
2pckSAHDiphthine synthase/0.661
2ed3SAHDiphthine synthase/0.658
2dxxSAHDiphthine synthase/0.655
2pb5SAHDiphthine synthase/0.655
1vceSAHDiphthine synthase/0.654
2eh2SAHDiphthine synthase/0.653
2owvSAHDiphthine synthase/0.653
2el0SAHDiphthine synthase/0.651
2eh4SAHDiphthine synthase/0.649
2dxwSAHDiphthine synthase/0.644
2e4nSAHDiphthine synthase/0.644
2ejkSAHDiphthine synthase/0.641
2pciSAHDiphthine synthase/0.633
2dxvSAHDiphthine synthase/0.627
2eglSAHDiphthine synthase/0.623
2dsgSAHDiphthine synthase/0.618
2hr8SAHDiphthine synthase/0.618
2e7rSAHDiphthine synthase/0.617
2huvSAHDiphthine synthase/0.616
2p9dSAHDiphthine synthase/0.616
2p6lSAHDiphthine synthase/0.614
2owgSAHDiphthine synthase/0.613
2ehlSAHDiphthine synthase/0.609
2emrSAHDiphthine synthase/0.604
2owfSAHDiphthine synthase/0.604
2e16SAHDiphthine synthase/0.601
2pb6SAHDiphthine synthase/0.601
2el3SAHDiphthine synthase/0.595
2dv3SAHDiphthine synthase/0.591
2emuSAHDiphthine synthase/0.588
2pcaSAHDiphthine synthase/0.582
2pb4SAHDiphthine synthase/0.579
2eh5SAHDiphthine synthase/0.578
2ek7SAHDiphthine synthase/0.578
2en5SAHDiphthine synthase/0.576
2e8rSAHDiphthine synthase/0.572
2e8qSAHDiphthine synthase/0.571
2p6dSAHDiphthine synthase/0.571
2eleSAHDiphthine synthase/0.567
2pcgSAHDiphthine synthase/0.561
2e8sSAHDiphthine synthase/0.560
2pcmSAHDiphthine synthase/0.554
2ejzSAHDiphthine synthase/0.553
2huxSAHDiphthine synthase/0.553
2ekaSAHDiphthine synthase/0.551
2eldSAHDiphthine synthase/0.549
2ek4SAHDiphthine synthase/0.548
2pchSAHDiphthine synthase/0.538
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.503
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.491
1xe55FEPlasmepsin-23.4.23.390.490
2gjlFMNNitronate monooxygenase1.13.12.160.484
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
5c77SAHProtein arginine N-methyltransferase SFM1/0.482
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.478
3gw9VNILanosterol 14-alpha-demethylase/0.473
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.472
3to6LYS_CMCHistone acetyltransferase ESA1/0.468
3ox4NADAlcohol dehydrogenase 21.1.1.10.467
1v9aSAHUncharacterized protein/0.466
2xhd7T9Glutamate receptor 2/0.466
4m83ERYOleandomycin glycosyltransferase2.4.10.466
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.466
4g3jVNTLanosterol 14-alpha-demethylase/0.465
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.464
4g7gVFVLanosterol 14-alpha-demethylase/0.464
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.463
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
1g63FMNEpidermin decarboxylase4.1.10.462
1zeoC01Peroxisome proliferator-activated receptor gamma/0.462
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.462
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1x1aSAMC-20 methyltransferase/0.461
3zh8C58Protein kinase C iota type2.7.11.130.461
1x1bSAHC-20 methyltransferase/0.460
2pswCOAN-alpha-acetyltransferase 50/0.460
2q5g1FAPeroxisome proliferator-activated receptor delta/0.460
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.460
3gqvNAPEnoyl reductase LovC10.460
1dirNADDihydropteridine reductase1.5.1.340.459
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.459
1rneC60Renin3.4.23.150.459
1tqf32PBeta-secretase 13.4.23.460.459
1x1cSAHC-20 methyltransferase/0.459
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.459
2rcyNAPPyrroline-5-carboxylate reductase/0.459
2y3sTIRTamL/0.459
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.459
4egbNADdTDP-glucose 4,6-dehydratase/0.459
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.458
2y3rTIRTamL/0.458
3lqfNADGalactitol dehydrogenase/0.458
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
2q4bNAPUncharacterized protein At5g02240/0.457
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.457
4dpuAGSMevalonate diphosphate decarboxylase/0.457
5af7FADAcyl-CoA dehydrogenase/0.457
1k7fIAVTryptophan synthase alpha chain/0.456
1mj9COAHistone acetyltransferase ESA1/0.456
2givACOHistone acetyltransferase KAT8/0.456
2zvcSAHPrecorrin-3 C17-methyltransferase/0.456
3d8bADPFidgetin-like protein 13.6.40.456
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.456
4f650S9Fibroblast growth factor receptor 1/0.456
5dozNDPJamJ/0.456
5hwsNAP2-dehydropantoate 2-reductase/0.456
2ou2ACOHistone acetyltransferase KAT5/0.455
2rlcCHDCholoylglycine hydrolase3.5.1.240.455
1w6hTITPlasmepsin-23.4.23.390.454
1xddAAYIntegrin alpha-L/0.454
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2ifaFMNUncharacterized protein/0.454
2qbuSAHPrecorrin-2 methyltransferase/0.454
3gvhNADMalate dehydrogenase/0.454
3ijoB4DGlutamate receptor 2/0.454
3kb1ADPIron-sulfur cluster carrier protein/0.454
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.454
5irnADPNucleotide binding oligomerization domain containing 2/0.454
1me6IVSPlasmepsin-23.4.23.390.453
1pjcNADAlanine dehydrogenase/0.453
1qorNDPQuinone oxidoreductase 1/0.453
1x1dSAHC-20 methyltransferase/0.453
3pqbVGPPutative oxidoreductase/0.453
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
2ahrNAPPyrroline-5-carboxylate reductase/0.452
2g1s4IGRenin3.4.23.150.452
2nq8ZIDEnoyl-ACP reductase/0.452
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.452
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4xumIMNPeroxisome proliferator-activated receptor gamma/0.452
5d3qGDPDynamin-13.6.5.50.452
5dp2NAPCurF/0.452
1f8wFADNADH peroxidase1.11.1.10.451
1tehNADAlcohol dehydrogenase class-31.1.1.10.451
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.451
2uxoTACHTH-type transcriptional regulator TtgR/0.451
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.451
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4oztP1AEcdysone receptor, putative/0.451
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.450
1lbcCYZGlutamate receptor 2/0.450
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.450
2z54AB1Gag-Pol polyprotein3.4.23.160.450
3vqsJT1Genome polyprotein/0.450
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.450
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.450
4yaoFMNNADPH--cytochrome P450 reductase/0.450
1mjaCOAHistone acetyltransferase ESA1/0.449
1pd9CO4Dihydrofolate reductase1.5.1.30.449
1y4lSVRBasic phospholipase A2 homolog 2/0.449
2oapANPType II secretion system protein (GspE-2)/0.449
2vbdV10Isopenicillin N synthase1.21.3.10.449
3enkUPGUDP-glucose 4-epimerase/0.449
3gwfNAPCyclohexanone monooxygenase/0.449
4eb7PLPCysteine desulfurase IscS 2/0.449
4i1iNADMalate dehydrogenase/0.449
4ji91M3Tyrosine-protein kinase JAK2/0.449
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.448
1vikBAYGag-Pol polyprotein/0.448
2ebaFADPutative glutaryl-CoA dehydrogenase/0.448
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.448
2xtnGTPGTPase IMAP family member 2/0.448
3r9uFADThioredoxin reductase/0.448
4djy0KRBeta-secretase 13.4.23.460.448
4h3j10WBeta-secretase 13.4.23.460.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.448
1xe65FPPlasmepsin-23.4.23.390.447
2a94AP0L-lactate dehydrogenase1.1.1.270.447
2c27ACOMycothiol acetyltransferase2.3.1.1890.447
2fznFADBifunctional protein PutA1.5.5.20.447
2wedPP6Penicillopepsin-13.4.23.200.447
2y3rTRKTamL/0.447
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.447
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.447
4i8zG08Gag-Pol polyprotein3.4.23.160.447
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.447
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.447
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.447
1f8fNADBenzyl alcohol dehydrogenase/0.446
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.446
2zjmF1MBeta-secretase 13.4.23.460.446
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3nutSAHPrecorrin-3 methylase/0.446
3pwm017Gag-Pol polyprotein3.4.23.160.446
1bwsNDPGDP-L-fucose synthase/0.445
1bxoPP7Penicillopepsin-13.4.23.200.445
1dr3TAPDihydrofolate reductase1.5.1.30.445
2a87FADThioredoxin reductase1.8.1.90.445
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.445
2g1r3IGRenin3.4.23.150.445
2g226IGRenin3.4.23.150.445
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.445
3hl0NADMaleylacetate reductase/0.445
3slkNDPPolyketide synthase extender module 2/0.445
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.445
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
1yb5NAPQuinone oxidoreductase1.6.5.50.444
2g247IGRenin3.4.23.150.444
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.444
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.444
3a3gDLZLumazine protein/0.444
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
3ig6438Urokinase-type plasminogen activator3.4.21.730.444
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.444
3qwbNDPProbable quinone oxidoreductase1.6.5.50.444
3sz0FADSulfide-quinone reductase/0.444
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.444
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.444
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.444
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.444
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1xl5190Gag-Pol polyprotein3.4.23.160.443
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.443
2gz7D3FOrf1a polyprotein/0.443
2vwqNAPGlucose 1-dehydrogenase/0.443
3phiNDPShikimate dehydrogenase (NADP(+))/0.443
3so9017Pol protein/0.443
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.443
4q73FADBifunctional protein PutA/0.443
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1orrNADCDP-paratose 2-epimerase/0.442
2rhgIGPTryptophan synthase alpha chain/0.442
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
3syiFADSulfide-quinone reductase/0.442
3wv9FEGHmd co-occurring protein HcgE/0.442
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.442
1zdwFLVPrenyltransferase/0.441
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.441
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.441
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2p5uNADUDP-glucose 4-epimerase/0.441
2pj4414Carboxypeptidase B/0.441
3toxNAPPutative oxidoreductase/0.441
4a8v2ANMajor pollen allergen Bet v 1-J/0.441
4bfzZVZPantothenate kinase2.7.1.330.441
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.441
1ie3NADMalate dehydrogenase/0.440
2is0I03Beta-secretase 13.4.23.460.440
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.440
3f1kNAPUncharacterized oxidoreductase YciK10.440
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.440
3mdmFJZCholesterol 24-hydroxylase/0.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3t14FADSulfide-quinone reductase/0.440
3tneRITCandidapepsin-13.4.23.240.440
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.440
4a81DXCMajor pollen allergen Bet v 1-A/0.440
4wudANPDNA gyrase subunit B/0.440