sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2inz | OHP | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.844 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.681 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.647 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.647 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.642 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.638 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.636 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.612 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.611 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.603 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.599 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.599 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.593 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.593 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.590 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.586 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.580 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.577 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.575 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.572 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.571 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.571 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.570 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.569 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.568 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.567 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.559 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.557 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.556 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.555 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.551 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.544 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.541 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.540 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.536 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.535 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.535 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.530 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.526 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.525 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.520 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.516 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.515 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.514 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.514 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.513 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.513 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.512 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.512 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.509 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.508 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.506 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.506 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.505 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.504 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.504 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.504 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.503 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.502 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.501 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.499 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.499 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.498 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.497 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.496 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.495 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.492 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.492 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.491 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.489 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.486 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.486 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.483 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.483 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.482 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.480 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.479 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.478 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.477 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.476 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.475 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.475 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.475 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.473 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.471 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.471 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.471 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.470 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.469 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.469 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.469 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.467 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.466 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.466 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.466 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.465 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4hcy | 0YN | Transketolase | / | 0.465 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.465 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.464 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.464 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.463 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.463 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1rxj | BNI | Streptavidin | / | 0.462 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.462 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.462 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.461 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.461 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.461 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.461 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.460 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.460 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.459 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.459 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.459 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.457 | |
| 2vxa | RBF | Dodecin | / | 0.457 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.457 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.457 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.455 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.455 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.455 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.454 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.454 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.454 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.454 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.454 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.454 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 1uhj | CZB | Aequorin-2 | / | 0.453 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.453 | |
| 2ohh | FMN | Type A flavoprotein FprA | 1 | 0.453 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.453 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.452 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.452 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.452 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.452 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.451 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.451 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.451 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.451 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.450 | |
| 4j7g | TRH | PCZA361.3 | / | 0.450 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.450 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.450 | |
| 4xcz | T3Q | Qdtf | / | 0.450 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1s36 | CEI | Obelin | / | 0.449 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.449 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.449 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.449 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.449 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.449 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.449 | |
| 1qv0 | CZH | Obelin | / | 0.448 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.448 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.448 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.448 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.448 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.448 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.447 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.447 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.447 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.447 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.446 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.446 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.446 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.445 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.445 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.445 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.445 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2hzq | STR | Apolipoprotein D | / | 0.444 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.444 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.443 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.443 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4qtn | NNR | Nicotinamide riboside transporter PnuC | / | 0.443 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.442 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.442 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.442 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.442 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3n61 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.441 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.441 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.441 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 3c1o | NAP | Eugenol synthase | / | 0.440 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.440 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.440 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4bvh | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.440 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.440 |