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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hfoFMNActivator of photopigment and puc expression

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hfoFMNActivator of photopigment and puc expression/1.000
2hfnFMNActivator of photopigment and puc expression/0.587
3mziFMNActivator of photopigment and puc expression/0.567
2bycFMNBlue-light receptor of the BLUF-family/0.558
1x0pFADTll0078 protein/0.541
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.505
4yusFMNFamily 3 adenylate cyclase/0.503
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.493
3gg0FMNUncharacterized protein/0.487
3gfzFMNUncharacterized protein/0.486
5eowFAD6-hydroxynicotinate 3-monooxygenase1.14.13.1140.485
3gfxFMNUncharacterized protein/0.482
4ctaATPCinA-like protein/0.481
4nt03DUOrotidine 5'-phosphate decarboxylase4.1.1.230.474
4i4e1BQFocal adhesion kinase 12.7.10.20.472
4jrnANPRhoptry kinase family protein/0.469
2yyuC5POrotidine 5'-phosphate decarboxylase/0.467
3gfyFMNUncharacterized protein/0.466
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.463
4jhz1KVBeta-glucuronidase3.2.1.310.463
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.462
2zzaFOLDihydrofolate reductase/0.462
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4s32ANPMitogen-activated protein kinase 12.7.11.240.462
4fz70VHTyrosine-protein kinase SYK2.7.10.20.461
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.461
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.459
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
3gg1FMNUncharacterized protein/0.458
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.457
3f0gC5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.457
4bcoT6QCyclin-dependent kinase 22.7.11.220.457
2nliFMNLactate oxidase/0.456
3q5iANPProtein kinase, putative/0.456
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.456
4o4eATPKinase/0.456
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1u3cFADCryptochrome-1/0.455
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.454
2q6cHR13-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.454
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.453
3clyACPFibroblast growth factor receptor 2/0.453
3datMTXDihydrofolate reductase/0.453
3uwqU5POrotidine 5'-phosphate decarboxylase/0.453
4uuxAPRCinA-like protein/0.453
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.452
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.452
2btdADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.452
2r4fRIE3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.452
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
3ztxZTXAurora kinase B-A2.7.11.10.452
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2ghmLICMitogen-activated protein kinase 14/0.451
2pmlANPUncharacterized protein/0.451
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
3is2FADVivid PAS protein VVD/0.451
3k3bADPKinesin-like protein KIF11/0.451
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4zolACPTubulin tyrosine ligase/0.451
2iyiFMNAppA, antirepressor of ppsR, sensor of blue light/0.450
2wotZZGTGF-beta receptor type-12.7.11.300.450
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.450
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4j33FADKynurenine 3-monooxygenase/0.450
1vruAAPGag-Pol polyprotein2.7.7.490.449
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
3tdwGDPGentamicin resistance protein/0.449
3wdmADN4-phosphopantoate--beta-alanine ligase6.3.2.360.449
4o4fATPKinase/0.449
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
5auwQUEDeath-associated protein kinase 12.7.11.10.449
1ir3ANPInsulin receptor2.7.10.10.448
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.448
3juhANPCasein kinase II subunit alpha2.7.11.10.448
3wo0ADPAlanine--anticapsin ligase/0.448
4n57ADPAPH(2'')-Id/0.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.447
2vgoAD5Aurora kinase B-A2.7.11.10.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
3epoMP5Phosphomethylpyrimidine synthase/0.447
3m8p65BGag-Pol polyprotein2.7.7.490.447
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.447
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.447
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2imlFMNUncharacterized protein/0.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1gx1CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.445
2xanANPInositol-pentakisphosphate 2-kinase2.7.1.1580.445
3fgoCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
3h86AP5Adenylate kinase/0.445
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4xvuATPATPase GET3/0.445
2v7a627Tyrosine-protein kinase ABL12.7.10.20.444
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.444
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4x2dATPFic family protein putative filamentation induced by cAMP protein/0.444
4xlvACPInsulin receptor2.7.10.10.444
1adfTADAlcohol dehydrogenase E chain1.1.1.10.443
3udzADPInositol-pentakisphosphate 2-kinase2.7.1.1580.443
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.443
4jln18VDeoxycytidine kinase2.7.1.740.443
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1fnnADPORC1-type DNA replication protein/0.442
2acxANPG protein-coupled receptor kinase 62.7.11.160.442
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3ua3SAHProtein arginine N-methyltransferase 5/0.442
4brxKGWFocal adhesion kinase 12.7.10.20.442
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4kf1HT5Aryldialkylphosphatase3.1.8.10.442
4l9kEHFSerum albumin/0.442
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.441
2q6bHR23-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.441
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4lj3C2ECyclic di-GMP phosphodiesterase YahA3.1.40.441
5ez4NADBetaine-aldehyde dehydrogenase/0.441
1j39UPGDNA beta-glucosyltransferase/0.440
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2e20B4PPropionate kinase/0.440
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.440
3eek53SUncharacterized protein/0.440
3k5uPFQAurora kinase A2.7.11.10.440
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.440
4d58BI9Focal adhesion kinase 12.7.10.20.440
4y95746Tyrosine-protein kinase/0.440
5c7oNADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific1.2.1.120.440