Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2g1m4HGEgl nine homolog 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2g1m4HGEgl nine homolog 1/1.000
4bqwQNMEgl nine homolog 1/0.657
4jzr4JREgl nine homolog 1/0.638
4bqyFNTEgl nine homolog 1/0.601
4xmxBESAminopeptidase N3.4.11.20.489
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.488
4xgxADPFAD:protein FMN transferase/0.488
2jl1NAPTriphenylmethane reductase/0.482
3fr5I4AFatty acid-binding protein, adipocyte/0.479
4kbz1QAEgl nine homolog 1/0.478
3nh8DC2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)3.5.1.1140.472
2freFMNNAD(P)H-flavin oxidoreductase/0.470
3af3GCPPantothenate kinase2.7.1.330.469
3gh8FMNIodotyrosine deiodinase 11.21.1.10.469
3hpqAP5Adenylate kinase/0.469
4a5lNDPThioredoxin reductase/0.469
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.468
4fxy0W2Neurolysin, mitochondrial3.4.24.160.465
1p4aPCPPur operon repressor/0.464
4nmdFDABifunctional protein PutA/0.464
5idwNAPShort-chain dehydrogenase/reductase SDR/0.462
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.461
4yp05IQHistidyl-tRNA synthetase, putative/0.461
1towCRZFatty acid-binding protein, adipocyte/0.460
1zgi382Prothrombin3.4.21.50.460
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.460
3af1GDPPantothenate kinase2.7.1.330.460
4cf7ADPAdenylate kinase/0.460
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.459
4df2FMNNADPH dehydrogenase/0.459
1x2hLPALipoate-protein ligase A6.3.1.200.458
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.458
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.458
2x06NADL-sulfolactate dehydrogenase/0.457
4nauAGSPhosphopantetheine adenylyltransferase/0.457
4qaiFMNNADPH dehydrogenase/0.457
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.456
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.456
1xq6NAPUncharacterized protein At5g02240/0.456
4a6aTTPdCTP deaminase3.5.4.130.456
1kqbFMNOxygen-insensitive NAD(P)H nitroreductase/0.455
3lm8VIBThiamine pyrophosphokinase2.7.6.20.455
3otwCOAPhosphopantetheine adenylyltransferase/0.455
4hnhNAPNAD-dependent epimerase/dehydratase/0.455
4yal2AMNADPH--cytochrome P450 reductase/0.455
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1rpnNDPGDP-mannose 4,6-dehydratase/0.454
2a94AP0L-lactate dehydrogenase1.1.1.270.454
3to3ATPPetrobactin biosynthesis protein AsbB/0.454
1v93FADMethylenetetrahydrofolate reductase/0.453
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.453
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.453
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3fql79ZGenome polyprotein2.7.7.480.452
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.452
1nzfUPGDNA beta-glucosyltransferase/0.451
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
4oztP1AEcdysone receptor, putative/0.451
4twnB96Ephrin type-A receptor 32.7.10.10.451
1u1f183Uridine phosphorylase2.4.2.30.450
2an9GDPGuanylate kinase2.7.4.80.450
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.450
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
4m5pFMNNADPH dehydrogenase/0.450
1z0dGDPRas-related protein Rab-5C/0.449
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.449
2b9yFADPutative aminooxidase/0.449
3isjA8DPantothenate synthetase6.3.2.10.449
3ixp834Ecdysone receptor/0.449
4jx1CAHCamphor 5-monooxygenase1.14.15.10.449
4xyeNADFormate dehydrogenase/0.449
2xf3J01Uncharacterized protein/0.448
3h06VBPGlutamate receptor 2/0.448
3p8iFMNPentaerythritol tetranitrate reductase/0.448
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.447
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.447
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.447
2q4bNAPUncharacterized protein At5g02240/0.447
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.447
3sopGDPNeuronal-specific septin-3/0.447
4ddhMS0Pantothenate synthetase6.3.2.10.447
5cwa0GAAnthranilate synthase component 14.1.3.270.447
1lb9DNQGlutamate receptor 2/0.446
1lkeDOGBilin-binding protein/0.446
1pq944BOxysterols receptor LXR-beta/0.446
2bacFADPutative aminooxidase/0.446
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.446
3bv2P38Mitogen-activated protein kinase 14/0.446
3ekuCY9Actin-5C/0.446
3vhxGTPADP-ribosylation factor 6/0.446
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4djaFAD(6-4) photolyase/0.446
4h9tHL4Phosphotriesterase/0.446
4j36FADKynurenine 3-monooxygenase/0.446
4nu0AP5Adenylate kinase/0.446
4uugPXGBranched-chain amino acid aminotransferase, putative/0.446
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.446
1axeNADAlcohol dehydrogenase E chain1.1.1.10.445
1h51FMNPentaerythritol tetranitrate reductase/0.445
2rqfJH3Hemolymph juvenile hormone binding protein/0.445
2tpsTPSThiamine-phosphate synthase/0.445
3cluFADElectron transfer flavoprotein subunit alpha/0.445
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.445
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.445
4z0g5GPInosine-5'-monophosphate dehydrogenase/0.445
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.444
1icsFMN12-oxophytodienoate reductase 11.3.1.420.444
1kp2ATPArgininosuccinate synthase6.3.4.50.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
2hdjNDPAldo-keto reductase family 1 member C2/0.444
2yvgNADFerredoxin reductase/0.444
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.444
3fr28CAFatty acid-binding protein, adipocyte/0.444
3hl0NADMaleylacetate reductase/0.444
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.444
3r9iADPSeptum site-determining protein MinD/0.444
3rpeFADPutative modulator of drug activity/0.444
3wb2YGPUncharacterized protein MJ0488/0.444
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
1h50FMNPentaerythritol tetranitrate reductase/0.443
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.443
1pwuGM6Lethal factor3.4.24.830.443
2bpoNAPNADPH--cytochrome P450 reductase/0.443
2f3rG5PGuanylate kinase2.7.4.80.443
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4bfsZVSPantothenate kinase2.7.1.330.443
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4r1lADPPhenylacetate-coenzyme A ligase/0.443
4w5jAP5Adenylate kinase/0.443
4wzhFMNDihydroorotate dehydrogenase (fumarate)/0.443
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.442
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.442
4a2aATPCell division protein FtsA/0.442
4gvzADPArginine kinase2.7.3.30.442
4n3l2FNProthrombin3.4.21.50.442
4p13FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
1eioGCHGastrotropin/0.441
1wc1TATAdenylate cyclase/0.441
2pc4ASP_TRP_ASNFructose-bisphosphate aldolase4.1.2.130.441
2wzmNA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346/0.441
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.441
3clrFADElectron transfer flavoprotein subunit alpha/0.441
3jzdNADMaleylacetate reductase/0.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.441
1hk2T44Serum albumin/0.440
1hldNADAlcohol dehydrogenase E chain1.1.1.10.440
1ojtFADDihydrolipoyl dehydrogenase/0.440
2d29FADAcyl-CoA dehydrogenase/0.440
2rc3NADCBS domain/0.440
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4bfzZVZPantothenate kinase2.7.1.330.440
4hdhATPGenome polyprotein2.7.7.480.440
4ifn12OKelch-like ECH-associated protein 1/0.440
4y8vADPAcyl-CoA synthetase (NDP forming)/0.440
5dozNDPJamJ/0.440