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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2f2kTGGAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2f2kTGGAldose reductase1.1.1.211.000
3u2cSUZAldose reductase1.1.1.210.725
2pdyFIDAldose reductase1.1.1.210.666
3v35NTIAldose reductase1.1.1.210.642
3s3gTLTAldose reductase1.1.1.210.614
1ef3FIDAldose reductase1.1.1.210.609
2inzOHPAldose reductase1.1.1.210.607
2pdwFIDAldose reductase1.1.1.210.604
2nvcITAAldose reductase1.1.1.210.599
2pd9FIDAldose reductase1.1.1.210.586
1pwmFIDAldose reductase1.1.1.210.584
2pdkSBIAldose reductase1.1.1.210.580
4gabFIDAldo-keto reductase family 1 member B101.1.10.576
3p2vDOYAldose reductase1.1.1.210.575
5liu388Aldo-keto reductase family 1 member B101.1.10.568
2agtFIDAldose reductase1.1.1.210.566
2is72CLAldose reductase1.1.1.210.566
2pdj393Aldose reductase1.1.1.210.566
2pdu393Aldose reductase1.1.1.210.566
1ekoI84Aldose reductase1.1.1.210.565
2iqdLPAAldose reductase1.1.1.210.555
2fz8ZSTAldose reductase1.1.1.210.554
1ah0SBIAldose reductase1.1.1.210.553
2pdfZSTAldose reductase1.1.1.210.552
3ghsLDTAldose reductase1.1.1.210.551
1el3I84Aldose reductase1.1.1.210.540
4wevSUZAldo-keto reductase family 1 member B101.1.10.540
2pdxZSTAldose reductase1.1.1.210.538
3ghrLDTAldose reductase1.1.1.210.537
2iki388Aldose reductase1.1.1.210.531
2pdp393Aldose reductase1.1.1.210.530
3ghtLDTAldose reductase1.1.1.210.529
4gca2X9Aldose reductase1.1.1.210.529
2fz9ZSTAldose reductase1.1.1.210.528
1ieiZESAldose reductase1.1.1.210.527
2i17LDTAldose reductase1.1.1.210.524
2pzn393Aldose reductase1.1.1.210.520
2dv0ZSTAldose reductase1.1.1.210.516
2hvoZSTAldose reductase1.1.1.210.516
1t40ID5Aldose reductase1.1.1.210.515
2pdh47DAldose reductase1.1.1.210.510
4ga8SBIAldo-keto reductase family 1 member B101.1.10.510
2hvnZSTAldose reductase1.1.1.210.509
3lboLDTAldose reductase1.1.1.210.508
3lqlLDTAldose reductase1.1.1.210.508
3m4h388Aldose reductase1.1.1.210.507
2pdg47DAldose reductase1.1.1.210.506
2hv5ZSTAldose reductase1.1.1.210.505
2pdlTOLAldose reductase1.1.1.210.502
3m64393Aldose reductase1.1.1.210.502
2fzdTOLAldose reductase1.1.1.210.501
1z3n3NAAldose reductase1.1.1.210.500
3mb9ZSTAldose reductase1.1.1.210.500
3ld5LDTAldose reductase1.1.1.210.498
4yu153NAldose reductase1.1.1.210.498
3lz5LDTAldose reductase1.1.1.210.497
2i16LDTAldose reductase1.1.1.210.496
3ghuLDTAldose reductase1.1.1.210.495
1z8962PAldose reductase1.1.1.210.494
2cbqTH2Neocarzinostatin/0.494
3lenZSTAldose reductase1.1.1.210.494
2ikj393Aldose reductase1.1.1.210.487
2qxwLDTAldose reductase1.1.1.210.487
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.482
1zgbA1EAcetylcholinesterase3.1.1.70.482
2jl1NAPTriphenylmethane reductase/0.480
3nu03TUDihydrofolate reductase1.5.1.30.480
2fzbTOLAldose reductase1.1.1.210.478
3g5eQ74Aldose reductase1.1.1.210.478
1us0LDTAldose reductase1.1.1.210.477
1u70MTXDihydrofolate reductase1.5.1.30.475
1frbZSTAldose reductase-related protein 2/0.474
2vbpVB1Isopenicillin N synthase1.21.3.10.473
3qeoLLTDeoxycytidine kinase2.7.1.740.473
2duxZSTAldose reductase1.1.1.210.471
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.471
4bfwZVWPantothenate kinase2.7.1.330.470
1ry8RUTAldo-keto reductase family 1 member C3/0.469
1rxjBNIStreptavidin/0.468
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.468
1kmsLIHDihydrofolate reductase1.5.1.30.467
1zq5E04Aldo-keto reductase family 1 member C3/0.467
2ipw2CLAldose reductase1.1.1.210.467
2xupTZ5Acetylcholinesterase3.1.1.70.467
3mc5393Aldose reductase1.1.1.210.466
1w76GNTAcetylcholinesterase3.1.1.70.465
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.465
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.465
5d6lCAUBeta-2 adrenergic receptor/0.465
1hfrMOTDihydrofolate reductase1.5.1.30.464
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.464
4kebFOLDihydrofolate reductase1.5.1.30.463
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.462
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.461
1lnmDTXBilin-binding protein/0.460
1q84TZ4Acetylcholinesterase3.1.1.70.460
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.460
2vcmM11Isopenicillin N synthase1.21.3.10.460
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.460
1ut6A8NAcetylcholinesterase3.1.1.70.459
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.459
1blzACVIsopenicillin N synthase1.21.3.10.458
1n0sFLUBilin-binding protein/0.458
1t41ID5Aldose reductase1.1.1.210.458
3qe2FMNNADPH--cytochrome P450 reductase/0.458
1lkeDOGBilin-binding protein/0.457
1mvtDTMDihydrofolate reductase1.5.1.30.457
1ohjCOPDihydrofolate reductase1.5.1.30.457
1pwlBFIAldose reductase1.1.1.210.457
3gyf51PDihydrofolate reductase1.5.1.30.457
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.457
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.457
1jumBERHTH-type transcriptional regulator QacR/0.456
2pdn47DAldose reductase1.1.1.210.456
3f3y4OABile salt sulfotransferase2.8.2.140.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.455
4bfuZVUPantothenate kinase2.7.1.330.455
4nv10FXFormyl transferase/0.455
4xo7ASDAldo-keto reductase family 1 member C2/0.455
1drfFOLDihydrofolate reductase1.5.1.30.454
1odcA8BAcetylcholinesterase3.1.1.70.454
2ckmAA7Acetylcholinesterase3.1.1.70.454
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.454
3zoiM2WIsopenicillin N synthase1.21.3.10.454
2pb1NFGGlucan 1,3-beta-glucosidase/0.453
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
1h22E10Acetylcholinesterase3.1.1.70.452
2aclL05Oxysterols receptor LXR-alpha/0.452
2pdbZSTAldose reductase1.1.1.210.452
2xlpNAPPutative flavin-containing monooxygenase/0.452
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3t423T4Aldose reductase1.1.1.210.452
3ntz3TZDihydrofolate reductase1.5.1.30.451
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.451
2xltNA0Putative flavin-containing monooxygenase/0.450
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.450
4bftZVTPantothenate kinase2.7.1.330.450
4m6l21VDihydrofolate reductase1.5.1.30.450
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2pdc393Aldose reductase1.1.1.210.449
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.449
2wzySQXSoluble acetylcholine receptor/0.449
2xugTZ4Acetylcholinesterase3.1.1.70.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
3n0hTOPDihydrofolate reductase1.5.1.30.448
3sfy3FYUncharacterized protein/0.448
4mqt2CUMuscarinic acetylcholine receptor M2/0.448
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.447
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
2bjsACVIsopenicillin N synthase1.21.3.10.447
2f3815MAldo-keto reductase family 1 member C3/0.447
2ikhLITAldose reductase1.1.1.210.447
2w3mFOLDihydrofolate reductase1.5.1.30.447
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.447
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.20.447
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.446
1eveE20Acetylcholinesterase3.1.1.70.446
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1pd9CO4Dihydrofolate reductase1.5.1.30.446
1xf0ASDAldo-keto reductase family 1 member C3/0.446
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.446
2gg3U13Methionine aminopeptidase/0.446
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.446
2w6cBM4Acetylcholinesterase3.1.1.70.446
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.446
1fvpFMANon-fluorescent flavoprotein/0.445
1zgcA2EAcetylcholinesterase3.1.1.70.445
2pdq47DAldose reductase1.1.1.210.445
4m6kFOLDihydrofolate reductase1.5.1.30.445
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.444
1hb3SCVIsopenicillin N synthase1.21.3.10.444
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.444
2aovC2MHistamine N-methyltransferase2.1.1.80.444
3c3xNAPEugenol synthase 11.1.1.3180.444
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
1qiqACCIsopenicillin N synthase1.21.3.10.443
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2vqzMGTPolymerase basic protein 2/0.443
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.443
2xuhTZ4Acetylcholinesterase3.1.1.70.443
2xujTZ5Acetylcholinesterase3.1.1.70.443
4dbs0HVAldo-keto reductase family 1 member C3/0.443
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.443
4j7hTRHPCZA361.3/0.443
4jpg1OXPyruvate kinase PKM2.7.1.400.443
4qa2SHHHistone deacetylase 83.5.1.980.443
1s1rNAPAldo-keto reductase family 1 member C3/0.442
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2vqqTFGHistone deacetylase 43.5.1.980.442
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
3sytNADGlutamine-dependent NAD(+) synthetase6.3.5.10.442
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.442
1p0pBCHCholinesterase3.1.1.80.441
2d06ESTSulfotransferase 1A12.8.2.10.441
2j3qTFLAcetylcholinesterase3.1.1.70.441
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3c1oNAPEugenol synthase/0.441
3uweVJJAldo-keto reductase family 1 member C3/0.441
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.441
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.440
1obnASVIsopenicillin N synthase1.21.3.10.440
1ry0PG2Aldo-keto reductase family 1 member C3/0.440
2r7nADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.440
2xuiTZ5Acetylcholinesterase3.1.1.70.440
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3l3rOAGDihydrofolate reductase1.5.1.30.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.440
4kfjFOLDihydrofolate reductase1.5.1.30.440