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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a9z26AAdenosine kinase2.7.1.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a9z26AAdenosine kinase2.7.1.201.000
2a9y26AAdenosine kinase2.7.1.200.721
2ab8MTPAdenosine kinase2.7.1.200.579
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.508
4bfxZVXPantothenate kinase2.7.1.330.492
3h3t16HCollagen type IV alpha-3-binding protein/0.490
3e8xNAPBH1520 protein/0.486
5dp2NAPCurF/0.485
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.484
3h3r14HCollagen type IV alpha-3-binding protein/0.484
2x06NADL-sulfolactate dehydrogenase/0.483
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.479
4bftZVTPantothenate kinase2.7.1.330.479
3h3sH15Collagen type IV alpha-3-binding protein/0.475
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
3pqbVGPPutative oxidoreductase/0.471
3bi6396Wee1-like protein kinase2.7.10.20.469
3fhxPXLPyridoxal kinase2.7.1.350.469
4b4vL34Bifunctional protein FolD/0.468
1kquBR4Phospholipase A2, membrane associated/0.467
4bfzZVZPantothenate kinase2.7.1.330.464
1cjtFOKAdenylate cyclase type 2/0.462
1cjtFOKAdenylate cyclase type 5/0.462
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.462
3i0pNADMalate dehydrogenase, putative/0.462
1pwuGM6Lethal factor3.4.24.830.461
1vbiNADMalate/L-lactate dehydrogenase family protein/0.460
4bfsZVSPantothenate kinase2.7.1.330.460
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.459
4lb2DM5Serum albumin/0.459
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
1xddAAYIntegrin alpha-L/0.458
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3pm1ETHTH-type transcriptional regulator QacR/0.458
3qfrFMNNADPH--cytochrome P450 reductase/0.458
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.458
4b4w9L9Bifunctional protein FolD/0.458
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2po7CHDFerrochelatase, mitochondrial4.99.1.10.457
3iktNADRedox-sensing transcriptional repressor Rex/0.457
3zoiM2WIsopenicillin N synthase1.21.3.10.457
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2q5g1FAPeroxisome proliferator-activated receptor delta/0.456
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.456
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.455
3g72A6TRenin3.4.23.150.455
4bfvZVVPantothenate kinase2.7.1.330.455
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.454
2geuCOKPantothenate kinase2.7.1.330.454
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4isuIKMGlutamate receptor 2/0.454
1cqp803Integrin alpha-L/0.453
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.453
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.453
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
3keqNADRedox-sensing transcriptional repressor Rex/0.452
3slkNDPPolyketide synthase extender module 2/0.452
1oc1ASVIsopenicillin N synthase1.21.3.10.451
3g7jGTXGlutathione transferase GST1-4/0.451
4g3jVNTLanosterol 14-alpha-demethylase/0.451
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
1diuBDMDihydrofolate reductase1.5.1.30.450
1jq5NADGlycerol dehydrogenase1.1.1.60.450
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.450
3qe2FMNNADPH--cytochrome P450 reductase/0.450
3r9uFADThioredoxin reductase/0.450
4bfuZVUPantothenate kinase2.7.1.330.450
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
1kqwRTLCellular retinol-binding protein type II/0.449
2g274LGRenin3.4.23.150.449
2xfyACXBeta-amylase3.2.1.20.449
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.449
3k1wBFXRenin3.4.23.150.449
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.449
2zymACXPeriplasmic binding protein/0.448
2zynBCDPeriplasmic binding protein/0.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.448
3vf60H6Glucokinase2.7.1.20.448
4a83DXCMajor pollen allergen Bet v 1-A/0.448
4twnB96Ephrin type-A receptor 32.7.10.10.448
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.447
1x1bSAHC-20 methyltransferase/0.447
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.447
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.447
1b2lNDCAlcohol dehydrogenase1.1.1.10.446
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.446
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
3gncQQQGlutaryl-CoA dehydrogenase/0.446
3mteSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.446
4eqwCOACoenzyme A disulfide reductase/0.446
4ktl1CQCytochrome P450/0.446
1zg32HIIsoflavone 4'-O-methyltransferase/0.445
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3ts1TYATyrosine--tRNA ligase6.1.1.10.445
4jqh1MFAlr2278 protein/0.445
1osvCHCBile acid receptor/0.444
1swtBTNStreptavidin/0.444
2gjnFMNNitronate monooxygenase1.13.12.160.444
3b7dCNIGlutamate receptor 2/0.444
3oqkS52Renin3.4.23.150.444
4i1nFOLDihydrofolate reductase1.5.1.30.444
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1culFOKAdenylate cyclase type 2/0.443
1culFOKAdenylate cyclase type 5/0.443
1h61PDNPentaerythritol tetranitrate reductase/0.443
2g1n1IGRenin3.4.23.150.443
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.443
3btjDEQHTH-type transcriptional regulator QacR/0.443
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
1eioGCHGastrotropin/0.442
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1v35NAIEnoyl-ACP reductase/0.442
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2b4yAPRNAD-dependent protein deacylase sirtuin-5, mitochondrial/0.442
2ykiYKIHeat shock protein HSP 90-alpha/0.442
3arvSAUChitinase A/0.442
3fhxPLPPyridoxal kinase2.7.1.350.442
3g70A5TRenin3.4.23.150.442
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3wquATPCell division protein FtsA/0.442
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.442
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.442
1db48INPhospholipase A2, membrane associated/0.441
1o5rFR9Adenosine deaminase3.5.4.40.441
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.441
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.441
5jy1NADPutative short-chain dehydrogenase/reductase/0.441
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.440
1xuoLA1Integrin alpha-L/0.440
2dvlFADAcyl-CoA dehydrogenase/0.440
2il2LIXRenin3.4.23.150.440
2nnqT4BFatty acid-binding protein, adipocyte/0.440
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.440
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3rsv3RSBeta-secretase 13.4.23.460.440
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
4nzhFADL-ornithine N(5)-monooxygenase/0.440
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440