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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.153

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1531.000
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.611
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.599
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.598
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.595
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.583
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.571
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.570
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.566
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.564
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.560
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.559
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.553
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.549
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.544
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.543
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.541
4fa60TAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.539
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.539
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.538
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.536
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.535
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.531
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.529
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.527
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.525
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.522
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.522
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.514
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.513
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.513
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.512
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.501
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.501
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.500
2pvnP63Casein kinase II subunit alpha2.7.11.10.494
4bcmT7ZCyclin-dependent kinase 22.7.11.220.493
5av2KMPDeath-associated protein kinase 12.7.11.10.491
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.489
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.487
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.486
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.485
5av3KMPDeath-associated protein kinase 12.7.11.10.482
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.481
3at4CCKCasein kinase II subunit alpha2.7.11.10.476
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
1aq1STUCyclin-dependent kinase 22.7.11.220.475
3be9P04Casein kinase II subunit alpha2.7.11.10.472
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.472
1oiyN41Cyclin-dependent kinase 22.7.11.220.471
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.471
2zjwREFCasein kinase II subunit alpha2.7.11.10.469
3ibeL64Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.469
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.468
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4dgnLU2Casein kinase II subunit alpha2.7.11.10.466
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.464
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.464
3lfnA27Cyclin-dependent kinase 22.7.11.220.463
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.463
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4y93746Tyrosine-protein kinase/0.463
2ckeIQUDeath-associated protein kinase 2/0.462
3lltANPProtein serine/threonine kinase-1/0.462
3rak03ZCyclin-dependent kinase 22.7.11.220.462
1gii1PUCyclin-dependent kinase 22.7.11.220.461
2yaaATPDeath-associated protein kinase 2/0.460
3pe2E1BCasein kinase II subunit alpha2.7.11.10.460
2izuP01Casein kinase I isoform gamma-32.7.11.10.459
2pvlP55Casein kinase II subunit alpha2.7.11.10.459
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3gubGUBDeath-associated protein kinase 12.7.11.10.459
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.459
4ocvANPAminoglycoside phosphotransferase/0.459
3zewSTUEphrin type-B receptor 42.7.10.10.458
5cvfATPCasein kinase II subunit alpha2.7.11.10.458
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
4jqeANPCasein kinase II subunit alpha2.7.11.10.457
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
3q9xEMOCasein kinase II subunit alpha2.7.11.10.455
3r7yZ04Cyclin-dependent kinase 22.7.11.220.455
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.455
3bhy7CPDeath-associated protein kinase 3/0.454
4grb0XGCasein kinase II subunit alpha2.7.11.10.454
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.454
2vttLZDCyclin-dependent kinase 22.7.11.220.453
4dgo0JWCasein kinase II subunit alpha2.7.11.10.453
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.452
4mcb21WtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.452
1r78FMDCyclin-dependent kinase 22.7.11.220.451
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.451
4anmWULCasein kinase II subunit alpha2.7.11.10.451
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
3my5RFZCyclin-dependent kinase 22.7.11.220.450
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.449
3gu83GUDeath-associated protein kinase 12.7.11.10.449
3ral04ZCyclin-dependent kinase 22.7.11.220.449
4fob0USALK tyrosine kinase receptor2.7.10.10.449
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
3bqr4RBDeath-associated protein kinase 3/0.448
3ezvEZVCyclin-dependent kinase 22.7.11.220.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.448
3sheI85MAP kinase-activated protein kinase 32.7.11.10.448
1zp3FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.447
2ijmADPFocal adhesion kinase 12.7.10.20.447
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.447
3dfcANPDeath-associated protein kinase 12.7.11.10.446
4j99ACPFibroblast growth factor receptor 2/0.446
4jia1K3Tyrosine-protein kinase JAK2/0.446
5cshATPCasein kinase II subunit alpha2.7.11.10.446
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.445
1wvySTUDeath-associated protein kinase 12.7.11.10.445
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.445
4j95ACPFibroblast growth factor receptor 2/0.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.444
3nga3NGCasein kinase II subunit alpha2.7.11.10.444
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.444
3r7vZ02Cyclin-dependent kinase 22.7.11.220.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
3u4uLNHCasein kinase II subunit alpha2.7.11.10.443
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.443
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.443
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.443
1h1s4SPCyclin-dependent kinase 22.7.11.220.442
2fvdLIACyclin-dependent kinase 22.7.11.220.442
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
3lpbNVBTyrosine-protein kinase JAK2/0.442
3oqkS52Renin3.4.23.150.442
5e8xSTUTGF-beta receptor type-12.7.11.300.442
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1urwI1PCyclin-dependent kinase 22.7.11.220.441
2pvmP29Casein kinase II subunit alpha2.7.11.10.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.441
3kvxFMYMitogen-activated protein kinase 102.7.11.240.441
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.441
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
3ezrEZRCyclin-dependent kinase 22.7.11.220.440
3igoANPCalmodulin-domain protein kinase 1, putative/0.440