sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.750 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.741 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.733 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.689 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.684 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.651 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.596 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.593 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.591 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.587 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.585 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.583 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.582 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.575 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.574 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.573 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.569 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.565 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.565 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.564 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.564 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.560 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.557 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.554 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.552 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.551 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.538 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.529 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.514 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.513 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.499 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.492 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.492 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.489 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.485 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.478 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.474 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.473 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.472 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.472 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.469 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.469 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.468 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.466 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.465 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.464 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.464 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.463 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.463 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.460 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.459 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.459 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.458 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.458 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.456 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.454 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.453 | |
| 1l4m | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.452 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 2y3r | TRK | TamL | / | 0.452 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.452 | |
| 4u7w | NDP | MxaA | / | 0.452 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.451 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.451 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.451 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.451 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.450 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.450 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.449 | |
| 2bxm | IMN | Serum albumin | / | 0.449 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.449 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.449 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.448 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.448 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.448 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.447 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.447 | |
| 3k14 | 535 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.447 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.447 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 3el0 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.446 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.445 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.445 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.445 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.444 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.444 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.444 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.444 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.444 | |
| 4dja | FAD | (6-4) photolyase | / | 0.444 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1w87 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.441 | |
| 2b5v | NAP | Glucose 1-dehydrogenase | / | 0.441 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3gob | HXX | DdmC | / | 0.441 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.441 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.441 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.440 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.440 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.440 |