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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.291.000
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.724
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.640
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.625
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.624
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.622
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.615
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.600
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.599
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.591
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.581
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.581
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.578
4gcxPRFQueuine tRNA-ribosyltransferase2.4.2.290.574
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.572
3bllBPQQueuine tRNA-ribosyltransferase2.4.2.290.569
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.567
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.558
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.549
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.547
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.537
1q65BHBQueuine tRNA-ribosyltransferase2.4.2.290.536
3sm0AEKQueuine tRNA-ribosyltransferase2.4.2.290.535
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.531
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.531
4hvxQEIQueuine tRNA-ribosyltransferase2.4.2.290.530
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.290.529
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.524
1p0ePRFQueuine tRNA-ribosyltransferase2.4.2.290.514
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.506
4gkt0O1Queuine tRNA-ribosyltransferase2.4.2.290.506
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.503
3gc52MQQueuine tRNA-ribosyltransferase2.4.2.290.498
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.494
1r5yDQUQueuine tRNA-ribosyltransferase2.4.2.290.488
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.487
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.290.487
4y1bNAPAntE/0.485
4ndnSAMS-adenosylmethionine synthase isoform type-22.5.1.60.480
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.477
4s1iPLPPyridoxal kinase, putative/0.472
1y5vNE8Queuine tRNA-ribosyltransferase2.4.2.290.471
4q8pCKRQueuine tRNA-ribosyltransferase2.4.2.290.470
4pkwGM6Lethal factor3.4.24.830.469
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.467
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.466
1p33MTXPteridine reductase 11.5.1.330.464
2mokFMNFlavodoxin 1/0.463
2bn4FMNNADPH--cytochrome P450 reductase/0.462
3sl2ATPSensor histidine kinase WalK/0.459
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.459
4ocvANPAminoglycoside phosphotransferase/0.458
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
3bi6396Wee1-like protein kinase2.7.10.20.456
3gncQQQGlutaryl-CoA dehydrogenase/0.456
3hk1B64Fatty acid-binding protein, adipocyte/0.456
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.455
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.455
2b8jADNClass B acid phosphatase3.1.3.20.453
3fhxPXLPyridoxal kinase2.7.1.350.453
1kruIPTGalactoside O-acetyltransferase2.3.1.180.452
1ygkRRCPyridoxal kinase2.7.1.350.452
3eon341Glutaryl-CoA dehydrogenase/0.452
3pdqKC6Lysine-specific demethylase 4A1.14.110.452
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.452
4jva1ORcAMP-dependent protein kinase type II-beta regulatory subunit/0.450
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.449
1ove358Mitogen-activated protein kinase 14/0.448
2potGUNQueuine tRNA-ribosyltransferase2.4.2.290.448
1dliUDXUDP-glucose 6-dehydrogenase/0.447
2ejzSAHDiphthine synthase/0.447
3nxyD2HDihydrofolate reductase1.5.1.30.447
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.447
1el4CTZObelin/0.445
1vbiNADMalate/L-lactate dehydrogenase family protein/0.445
1ygjRMCPyridoxal kinase2.7.1.350.445
3evaSAHGenome polyprotein2.1.1.560.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.444
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.444
1bsvNDPGDP-L-fucose synthase/0.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
3rm8RM8Acidic mammalian chitinase3.2.1.140.443
5fm7ADPRuvB-like helicase/0.443
1ay0TPPTransketolase 12.2.1.10.442
1lb9DNQGlutamate receptor 2/0.442
1n3sGTPGTP cyclohydrolase 13.5.4.160.442
1oc1ASVIsopenicillin N synthase1.21.3.10.442
3c3eFO12-phospho-L-lactate transferase/0.442
3fhxPLPPyridoxal kinase2.7.1.350.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
4ryvZEAProtein LlR18A/0.442
4u0mGTPCyclic GMP-AMP synthase/0.442
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.441
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.441
3ivgFG5Pantothenate synthetase6.3.2.10.441
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4kttSAMS-adenosylmethionine synthase isoform type-22.5.1.60.441
1a9cGTPGTP cyclohydrolase 13.5.4.160.440
1dfoFFOSerine hydroxymethyltransferase2.1.2.10.440
3biz61EWee1-like protein kinase2.7.10.20.440
3fr5I4AFatty acid-binding protein, adipocyte/0.440
4eb5PLPCysteine desulfurase IscS 2/0.440
4f3gKAIGlutamate receptor 3/0.440