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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ez4NADL-lactate dehydrogenase1.1.1.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ez4NADL-lactate dehydrogenase1.1.1.271.000
3wswNADL-lactate dehydrogenase/0.551
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.551
2x0iNAIMalate dehydrogenase/0.550
3gvhNADMalate dehydrogenase/0.548
2aa3AP0L-lactate dehydrogenase/0.544
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.544
2a92NAIL-lactate dehydrogenase/0.540
3d4pNADL-lactate dehydrogenase 11.1.1.270.536
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.529
4i1iNADMalate dehydrogenase/0.527
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.502
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.502
4ipw1G7Mycocyclosin synthase1.14.21.90.498
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.494
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.494
2a94AP0L-lactate dehydrogenase1.1.1.270.493
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.491
1t2cNAIL-lactate dehydrogenase1.1.1.270.488
1ie3NADMalate dehydrogenase/0.487
4uunNAIL-lactate dehydrogenase/0.485
1uxjNADMalate dehydrogenase/0.481
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
1guyNADMalate dehydrogenase/0.475
3lqfNADGalactitol dehydrogenase/0.474
2ldbNADL-lactate dehydrogenase1.1.1.270.473
1uxkNADMalate dehydrogenase/0.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.470
1mjbACOHistone acetyltransferase ESA1/0.469
1jipKTN6-deoxyerythronolide B hydroxylase/0.465
1b8uNADMalate dehydrogenase/0.463
1wziNDPMalate dehydrogenase/0.462
1ur5NADMalate dehydrogenase/0.461
2x0rNADMalate dehydrogenase/0.461
4ajn88VL-lactate dehydrogenase A chain1.1.1.270.461
4gl4NAIAlcohol dehydrogenase class-3/0.461
1xddAAYIntegrin alpha-L/0.460
1llqNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.459
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.458
1gv0NADMalate dehydrogenase/0.457
4ambDUDPutative glycosyl transferase/0.457
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.456
3gwfFADCyclohexanone monooxygenase/0.455
4qecNAPElxO/0.455
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.454
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.453
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.453
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
4lcjNADC-terminal-binding protein 2/0.452
1fy7COAHistone acetyltransferase ESA1/0.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1xe65FPPlasmepsin-23.4.23.390.451
3uylTYDProbable NDP-rhamnosyltransferase/0.451
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.451
1jioDEB6-deoxyerythronolide B hydroxylase/0.450
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.450
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1wzeNADMalate dehydrogenase/0.449
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4nbwNADShort-chain dehydrogenase/reductase SDR/0.449
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
3pqfNADL-lactate dehydrogenase1.1.1.270.447
1bdmNAXMalate dehydrogenase/0.446
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2he5NDPAldo-keto reductase family 1 member C211.1.10.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2dv5SAHDiphthine synthase/0.445
2owuSAHDiphthine synthase/0.445
2p5fSAHDiphthine synthase/0.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.445
2ejzSAHDiphthine synthase/0.444
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3c1y2BADNA integrity scanning protein DisA/0.444
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.444
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1lbcCYZGlutamate receptor 2/0.443
2ed5SAHDiphthine synthase/0.443
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.443
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.443
4k6fNAPPutative Acetoacetyl-CoA reductase/0.443
4oqyNDP(S)-imine reductase/0.443
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1mjaCOAHistone acetyltransferase ESA1/0.442
1y7tNDPMalate dehydrogenase/0.442
2hldANPATP synthase subunit alpha, mitochondrial/0.442
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.442
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
5jlaNADPutative short-chain dehydrogenase/reductase/0.442
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.441
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
2j09FMNDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
2znq401Peroxisome proliferator-activated receptor delta/0.441
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4g3jVNTLanosterol 14-alpha-demethylase/0.441
4jqh1MFAlr2278 protein/0.441
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2dv4SAHDiphthine synthase/0.440
2z6rSAHDiphthine synthase/0.440
3ijoB4DGlutamate receptor 2/0.440
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440
4o3mADPBloom syndrome protein3.6.4.120.440