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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5kj1 NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.358
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.352
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.352
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.347
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.320
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.320
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.308
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.308
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.295
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.281
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.254
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.237
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.231
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.226
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.210
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.196
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.194
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.186
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.171
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.095
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.965
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.960
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.940
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.921
1yqd NAPSinapyl alcohol dehydrogenase / 0.919
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.917
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.909
3jv7 NADSecondary alcohol dehydrogenase / 0.897
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.891
3wle NAD(R)-specific carbonyl reductase / 0.885
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.872
4oaq NDPR-specific carbonyl reductase / 0.870
1yqx NAPSinapyl alcohol dehydrogenase / 0.866
3two NDPMannitol dehydrogenase / 0.863
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.850
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.844
4c4o NADSADH / 0.837
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.835
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.831
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.819
4cpd NADAlcohol dehydrogenase / 0.809
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.809
4rqu NADAlcohol dehydrogenase class-P / 0.807
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.806
1u7h NADPutative ornithine cyclodeaminase / 0.805
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.805
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.803
1uxj NADMalate dehydrogenase / 0.800
2xaa NADSecondary alcohol dehydrogenase / 0.800
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.798
1x7d NADPutative ornithine cyclodeaminase / 0.794
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.793
1gv0 NADMalate dehydrogenase / 0.789
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.782
1uxk NADMalate dehydrogenase / 0.778
4ejm NAPPutative zinc-binding dehydrogenase / 0.778
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.774
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.771
1o6z NADMalate dehydrogenase / 0.765
4l0q NADAlcohol dehydrogenase class-3 / 0.763
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.760
2dph NADFormaldehyde dismutase / 0.758
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.757
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.752
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.752
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.750
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.746
2vwh NAPGlucose 1-dehydrogenase / 0.744
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.742
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.742
2o4c NADErythronate-4-phosphate dehydrogenase / 0.741
4j49 NADUncharacterized protein / 0.738
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.737
4k28 NADShikimate dehydrogenase family protein / 0.736
4plp NADHomospermidine synthase 2.5.1.44 0.735
1ur5 NADMalate dehydrogenase / 0.734
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.733
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.731
4jji NADAlcohol dehydrogenase class-3 / 0.730
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.728
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.726
1sow NADL-lactate dehydrogenase 1.1.1.27 0.726
4b7x NAPProbable oxidoreductase / 0.726
2voj NADAlanine dehydrogenase 1.4.1.1 0.724
4i1i NADMalate dehydrogenase / 0.724
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.722
1guy NADMalate dehydrogenase / 0.721
4j43 NADUncharacterized protein / 0.719
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.719
3abi NADUncharacterized protein / 0.718
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.717
1llu NADAlcohol dehydrogenase / 0.714
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.711
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.711
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.709
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.707
1qor NDPQuinone oxidoreductase 1 / 0.706
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.705
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.701
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.701
5a02 NAPGlucose-fructose oxidoreductase / 0.701
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.700
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.700
1pzh NADLactate dehydrogenase / 0.697
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.696
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.695
3wfj NAD2-dehydropantoate 2-reductase / 0.695
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.695
1ie3 NADMalate dehydrogenase / 0.693
1wze NADMalate dehydrogenase / 0.692
2x0i NAIMalate dehydrogenase / 0.692
4xq9 NADHomospermidine synthase 2.5.1.44 0.688
1b8u NADMalate dehydrogenase / 0.687
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.686
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.686
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.686
3uko NADAlcohol dehydrogenase class-3 / 0.686
2y05 NAPProstaglandin reductase 1 / 0.685
2dfv NADL-threonine 3-dehydrogenase / 0.684
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.684
4xrg NADHomospermidine synthase 2.5.1.44 0.684
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.683
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.683
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.683
2vhx NADAlanine dehydrogenase 1.4.1.1 0.683
4j4b NAIUncharacterized protein / 0.683
2aa3 AP0L-lactate dehydrogenase / 0.682
5a1t NAIL-lactate dehydrogenase / 0.682
3ggo NAIPrephenate dehydrogenase / 0.680
3q2k NAIProbable oxidoreductase / 0.680
3kb6 NADD-lactate dehydrogenase / 0.679
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.679
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.678
2x0r NADMalate dehydrogenase / 0.676
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.675
2cda NAPGlucose 1-dehydrogenase / 0.674
4xqc NADHomospermidine synthase 2.5.1.44 0.674
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.673
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.673
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.673
4tvb NADHomospermidine synthase 2.5.1.44 0.673
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.672
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.671
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.671
3f3s NADLambda-crystallin homolog / 0.671
4jk3 NADUncharacterized protein / 0.671
5bsg NAPPyrroline-5-carboxylate reductase / 0.671
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.670
2yvg NADFerredoxin reductase / 0.670
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.669
3ggp NADPrephenate dehydrogenase / 0.669
1c1d NAIPhenylalanine dehydrogenase / 0.668
1pjc NADAlanine dehydrogenase / 0.667
4j49 NAIUncharacterized protein / 0.667
1pzf A3DLactate dehydrogenase / 0.666
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.665
3d64 NADAdenosylhomocysteinase / 0.664
2cdc NAPGlucose 1-dehydrogenase / 0.663
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.663
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.663
2c29 NAPDihydroflavonol 4-reductase / 0.662
3x2f NAIAdenosylhomocysteinase / 0.662
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.661
2hu2 NADC-terminal binding protein 1 / 0.661
2b5v NAPGlucose 1-dehydrogenase / 0.659
2uyy NA7Putative oxidoreductase GLYR1 1 0.659
1wzi NDPMalate dehydrogenase / 0.658
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.657
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
3ikt NADRedox-sensing transcriptional repressor Rex / 0.655
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.655
5br7 FADUDP-galactopyranose mutase / 0.655
3jyn NDPQuinone oxidoreductase / 0.654
2fkn NADUrocanate hydratase 4.2.1.49 0.653
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.652
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.652
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.652
1ib6 NADMalate dehydrogenase / 0.651
2dbz NAPGlyoxylate reductase 1.1.1.26 0.651
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.651
3hwr NDP2-dehydropantoate 2-reductase / 0.651
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650
3ec7 NADInositol 2-dehydrogenase / 0.650
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.650