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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cdt NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.358
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.352
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.347
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.320
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.295
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.285
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.278
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.268
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.237
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.222
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.195
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.179
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.094
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.079
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.064
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.959
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.956
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.941
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.926
1yqd NAPSinapyl alcohol dehydrogenase / 0.921
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.905
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.902
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.895
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.894
3jv7 NADSecondary alcohol dehydrogenase / 0.887
3two NDPMannitol dehydrogenase / 0.884
4oaq NDPR-specific carbonyl reductase / 0.875
1yqx NAPSinapyl alcohol dehydrogenase / 0.871
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.870
3wle NAD(R)-specific carbonyl reductase / 0.869
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.861
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.855
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.849
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.846
4c4o NADSADH / 0.830
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.826
1u7h NADPutative ornithine cyclodeaminase / 0.813
1x7d NADPutative ornithine cyclodeaminase / 0.811
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.810
4cpd NADAlcohol dehydrogenase / 0.809
4rqu NADAlcohol dehydrogenase class-P / 0.807
1uxj NADMalate dehydrogenase / 0.800
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.797
1f8f NADBenzyl alcohol dehydrogenase / 0.795
2xaa NADSecondary alcohol dehydrogenase / 0.795
2dph NADFormaldehyde dismutase / 0.791
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.787
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.782
1gv0 NADMalate dehydrogenase / 0.774
4jji NADAlcohol dehydrogenase class-3 / 0.774
1uxk NADMalate dehydrogenase / 0.772
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.771
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.770
1o6z NADMalate dehydrogenase / 0.766
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.766
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.765
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.760
4ejm NAPPutative zinc-binding dehydrogenase / 0.759
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.758
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.752
4l0q NADAlcohol dehydrogenase class-3 / 0.751
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.746
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.744
4j49 NADUncharacterized protein / 0.744
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.743
2voj NADAlanine dehydrogenase 1.4.1.1 0.743
4jk3 NADUncharacterized protein / 0.743
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.741
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.738
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.738
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.737
2o4c NADErythronate-4-phosphate dehydrogenase / 0.735
1ur5 NADMalate dehydrogenase / 0.733
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.731
1pzh NADLactate dehydrogenase / 0.728
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.728
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.727
2ejv NADL-threonine 3-dehydrogenase / 0.725
4i1i NADMalate dehydrogenase / 0.723
3wsw NADL-lactate dehydrogenase / 0.722
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.722
4j43 NADUncharacterized protein / 0.720
4plp NADHomospermidine synthase 2.5.1.44 0.717
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.717
1c1d NAIPhenylalanine dehydrogenase / 0.716
1sow NADL-lactate dehydrogenase 1.1.1.27 0.714
4b7x NAPProbable oxidoreductase / 0.714
3wfj NAD2-dehydropantoate 2-reductase / 0.712
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.712
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.711
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.711
3abi NADUncharacterized protein / 0.709
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.707
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.706
4xq9 NADHomospermidine synthase 2.5.1.44 0.705
4xrg NADHomospermidine synthase 2.5.1.44 0.705
1ie3 NADMalate dehydrogenase / 0.704
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
1llu NADAlcohol dehydrogenase / 0.703
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.702
3uko NADAlcohol dehydrogenase class-3 / 0.702
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.702
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.701
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.701
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.701
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.700
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.698
2vhx NADAlanine dehydrogenase 1.4.1.1 0.694
2vwh NAPGlucose 1-dehydrogenase / 0.693
3f3s NADLambda-crystallin homolog / 0.692
4tvb NADHomospermidine synthase 2.5.1.44 0.692
1wze NADMalate dehydrogenase / 0.691
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.691
4xqc NADHomospermidine synthase 2.5.1.44 0.689
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.687
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.685
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.685
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.683
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.683
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.683
1pjc NADAlanine dehydrogenase / 0.680
3oet NADErythronate-4-phosphate dehydrogenase / 0.680
1b8u NADMalate dehydrogenase / 0.679
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.679
3kb6 NADD-lactate dehydrogenase / 0.679
4j4b NAIUncharacterized protein / 0.678
2x0i NAIMalate dehydrogenase / 0.676
2x0r NADMalate dehydrogenase / 0.676
2cda NAPGlucose 1-dehydrogenase / 0.675
2d8a NADL-threonine 3-dehydrogenase / 0.675
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.675
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
2b5v NAPGlucose 1-dehydrogenase / 0.674
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.673
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.673
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.672
2v7g NADUrocanate hydratase 4.2.1.49 0.672
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.672
4k28 NADShikimate dehydrogenase family protein / 0.672
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.671
5a1t NAIL-lactate dehydrogenase / 0.671
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.670
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.670
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.669
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.669
3ggo NAIPrephenate dehydrogenase / 0.668
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.668
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.667
5a04 NDPGlucose-fructose oxidoreductase / 0.667
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.666
3hwr NDP2-dehydropantoate 2-reductase / 0.666
3d64 NADAdenosylhomocysteinase / 0.665
3x2f NAIAdenosylhomocysteinase / 0.664
5br7 FADUDP-galactopyranose mutase / 0.664
1bmd NADMalate dehydrogenase / 0.663
2cdc NAPGlucose 1-dehydrogenase / 0.663
2gsd NADFormate dehydrogenase / 0.663
2yvg NADFerredoxin reductase / 0.663
2c29 NAPDihydroflavonol 4-reductase / 0.662
3wid NAPGlucose 1-dehydrogenase / 0.661
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.660
3tqh NDPQuinone oxidoreductase / 0.660
4yai NAIC alpha-dehydrogenase / 0.660
2fkn NADUrocanate hydratase 4.2.1.49 0.659
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.657
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
4j49 NAIUncharacterized protein / 0.656
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.655
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.655
3ikt NADRedox-sensing transcriptional repressor Rex / 0.655
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.655
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.654
3keo NADRedox-sensing transcriptional repressor Rex / 0.654
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.654
3ggp NADPrephenate dehydrogenase / 0.653
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.653
1ib6 NADMalate dehydrogenase / 0.651
1jq5 NADGlycerol dehydrogenase 1.1.1.6 0.651
2dbz NAPGlyoxylate reductase 1.1.1.26 0.651
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.651
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.650