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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iai ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.158
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.044
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.042
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.031
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.030
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.027
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.024
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.010
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.008
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.996
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.992
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.983
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.963
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.956
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.953
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.953
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.944
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.941
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.940
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.928
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.910
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.904
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.889
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.875
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.864
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.861
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.860
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.860
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.844
4dee ADPAurora kinase A 2.7.11.1 0.844
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.839
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.826
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.821
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.821
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.819
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.818
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.817
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.816
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.815
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.813
4ysj ADPCalmodulin-like domain protein kinase / 0.809
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.805
5dt3 ATPAurora kinase A 2.7.11.1 0.804
4ceg ADPAurora kinase A 2.7.11.1 0.800
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.800
5dn3 ATPAurora kinase A 2.7.11.1 0.800
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.799
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.799
5dr2 ATPAurora kinase A 2.7.11.1 0.799
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.796
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.796
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.794
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.791
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.788
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.787
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.786
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.786
2pyw ADPMethylthioribose kinase 2.7.1.100 0.785
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.784
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.783
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.782
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.782
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.782
2pui ADPMethylthioribose kinase 2.7.1.100 0.780
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.780
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.780
1mq4 ADPAurora kinase A 2.7.11.1 0.778
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.778
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.777
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.774
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.773
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.772
5drd ATPAurora kinase A 2.7.11.1 0.771
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.770
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.766
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.766
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.765
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.765
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.763
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4qny ANPMitogen activated protein kinase, putative / 0.758
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.755
2olc ADPMethylthioribose kinase 2.7.1.100 0.752
2vqd AP2Biotin carboxylase 6.3.4.14 0.752
5dos ATPAurora kinase A 2.7.11.1 0.751
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.750
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.750
3c4z ADPRhodopsin kinase / 0.749
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.749
4bn1 ADPAurora kinase A 2.7.11.1 0.748
4ork GDPBifunctional AAC/APH 2.3.1 0.748
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.746
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.746
4utd ACPAurora kinase A 2.7.11.1 0.746
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.745
4gyi ADPUncharacterized protein / 0.744
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.738
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.736
1m0w ANPGlutathione synthetase 6.3.2.3 0.734
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.734
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.732
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.732
4xlv ACPInsulin receptor 2.7.10.1 0.729
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.727
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.726
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
5dnr ATPAurora kinase A 2.7.11.1 0.725
5iqb GNPBifunctional AAC/APH 2.3.1 0.725
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.722
4n57 ADPAPH(2'')-Id / 0.722
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.722
2py3 ACPFibroblast growth factor receptor 2 / 0.721
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.721
3g8c ADPBiotin carboxylase 6.3.4.14 0.721
1ol6 ATPAurora kinase A 2.7.11.1 0.720
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.720
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.719
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.717
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.717
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.715
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.714
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.714
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.714
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.713
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.713
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.713
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.713
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.712
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.712
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.711
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.710
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.710
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
2pul ACPMethylthioribose kinase 2.7.1.100 0.708
2pzp ACPFibroblast growth factor receptor 2 / 0.708
2zdg ADPD-alanine--D-alanine ligase / 0.708
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.708
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.708
5iqf GDPBifunctional AAC/APH 2.3.1 0.708
2pz5 ACPFibroblast growth factor receptor 2 / 0.707
3c4w ATPRhodopsin kinase / 0.707
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.706
3qc9 ADPRhodopsin kinase / 0.706
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.706
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.706
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.704
2j9g ADPBiotin carboxylase 6.3.4.14 0.704
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.703
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.701
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.701
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.700
5iqa GNPBifunctional AAC/APH 2.3.1 0.699
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.698
3tdw GDPGentamicin resistance protein / 0.697
3c50 ADPRhodopsin kinase / 0.696
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.696
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.695
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.695
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.695
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.695
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.694
4o1p ANPRibonuclease L / 0.693
4o4d ATPKinase / 0.693
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.692
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.692
3orl AGSSerine/threonine protein kinase / 0.692
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.692
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.691
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.691
3orp AGSSerine/threonine protein kinase / 0.690
5iqi GNPBifunctional AAC/APH 2.3.1 0.690
2wqe ADPAurora kinase A 2.7.11.1 0.688
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.688
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.688
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.687
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.686
2dwb ANPAurora kinase A 2.7.11.1 0.684
5byl GCPBifunctional AAC/APH 2.3.1 0.682
2pun ACPMethylthioribose kinase 2.7.1.100 0.681
3llt ANPProtein serine/threonine kinase-1 / 0.680
4o0w ADNAurora kinase A 2.7.11.1 0.679
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.679
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.678
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.678
3ork AGSSerine/threonine protein kinase / 0.678
2pup ADPMethylthioribose kinase 2.7.1.100 0.677
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.676
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.676
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.676
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.675
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.675
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.674
5ce3 ADPProtein kinase YopO / 0.673
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.672
3nie ANPMitogen-activated protein kinase / 0.672
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.672
1cm8 ANPMitogen-activated protein kinase 12 / 0.671
3orm AGSSerine/threonine protein kinase / 0.671
2emu SAHDiphthine synthase / 0.670
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.670
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.669
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.669
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.668
4ffr ATPUncharacterized protein / 0.666
4kpu FADElectron transfer flavoprotein alpha/beta-subunit / 0.666
3t8o ATPRhodopsin kinase / 0.665
3c4x ATPRhodopsin kinase / 0.663
3crz FADFerredoxin--NADP+ reductase / 0.663
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.663
4o4e ATPKinase / 0.663
3tw6 ADPPyruvate carboxylase / 0.662
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.662
5eg3 ACPFibroblast growth factor receptor 2 / 0.662
3tdv GDPGentamicin resistance protein / 0.661
4c3r ACPAurora kinase A 2.7.11.1 0.661
4dlz GNPGTPase HRas / 0.661
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.660
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.660
2yaa ATPDeath-associated protein kinase 2 / 0.660
3m0e ATPTranscriptional regulator (NtrC family) / 0.660
3rv4 ADPBiotin carboxylase 6.3.4.14 0.660
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.660
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.659
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.659
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.658
3ori AGSSerine/threonine protein kinase / 0.658
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.657
2pck SAHDiphthine synthase / 0.656
3bu5 ATPInsulin receptor 2.7.10.1 0.656
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.656
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
5dt4 ATPAurora kinase A 2.7.11.1 0.655
3mhy ATPNitrogen regulatory protein P-II 1 / 0.654
5iqg GDPBifunctional AAC/APH 2.3.1 0.654
1ol5 ADPAurora kinase A 2.7.11.1 0.653
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.653
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.653
4rz3 ADPSite-determining protein / 0.653
4u0o MTALipoyl synthase 2 / 0.653
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.652
3g8d ADPBiotin carboxylase 6.3.4.14 0.651
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650