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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iad ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.070
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.048
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.031
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.003
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.998
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.997
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.986
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.983
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.982
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.977
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.976
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.962
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.950
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.942
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.933
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.911
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.901
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.892
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.883
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.881
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.876
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.875
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.870
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.870
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.869
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.867
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.865
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.864
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.853
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.847
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.842
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.839
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.837
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.830
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.826
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.826
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.821
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.816
4ysj ADPCalmodulin-like domain protein kinase / 0.816
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.815
5dn3 ATPAurora kinase A 2.7.11.1 0.814
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.813
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.812
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.812
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.806
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.801
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.800
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.800
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.797
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.795
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.793
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.792
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.790
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.789
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.787
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.784
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.782
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.781
4dee ADPAurora kinase A 2.7.11.1 0.781
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.781
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.779
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.778
5dr2 ATPAurora kinase A 2.7.11.1 0.778
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.776
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.776
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.774
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.773
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.769
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.766
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.765
5dt3 ATPAurora kinase A 2.7.11.1 0.764
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.760
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.759
2pyw ADPMethylthioribose kinase 2.7.1.100 0.759
4ork GDPBifunctional AAC/APH 2.3.1 0.759
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.758
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.758
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.753
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.752
4qny ANPMitogen activated protein kinase, putative / 0.751
5drd ATPAurora kinase A 2.7.11.1 0.751
1mq4 ADPAurora kinase A 2.7.11.1 0.749
5iqb GNPBifunctional AAC/APH 2.3.1 0.746
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.744
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.743
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.742
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.741
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.741
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.740
2pml ANPUncharacterized protein / 0.739
4ceg ADPAurora kinase A 2.7.11.1 0.739
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.739
1cm8 ANPMitogen-activated protein kinase 12 / 0.737
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.734
3c4z ADPRhodopsin kinase / 0.734
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.733
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.733
5dos ATPAurora kinase A 2.7.11.1 0.733
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.732
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
4utd ACPAurora kinase A 2.7.11.1 0.732
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.731
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.731
5dnr ATPAurora kinase A 2.7.11.1 0.731
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.729
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.729
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.729
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.728
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.723
4ffr ATPUncharacterized protein / 0.723
3cly ACPFibroblast growth factor receptor 2 / 0.721
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.720
2vqd AP2Biotin carboxylase 6.3.4.14 0.720
5iqh GNPBifunctional AAC/APH 2.3.1 0.720
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.717
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.716
2olc ADPMethylthioribose kinase 2.7.1.100 0.714
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.713
2zdg ADPD-alanine--D-alanine ligase / 0.712
5byl GCPBifunctional AAC/APH 2.3.1 0.712
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.710
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.710
3c50 ADPRhodopsin kinase / 0.708
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.706
3wnz ADPAlanine--anticapsin ligase / 0.704
5iqf GDPBifunctional AAC/APH 2.3.1 0.704
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.701
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.699
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.699
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.699
4gyi ADPUncharacterized protein / 0.697
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.696
2pui ADPMethylthioribose kinase 2.7.1.100 0.696
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.696
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.693
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.693
3qc9 ADPRhodopsin kinase / 0.693
3g8c ADPBiotin carboxylase 6.3.4.14 0.692
3iew CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.692
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.691
4lv8 ADPRhoptry protein 5 C / 0.691
3tdw GDPGentamicin resistance protein / 0.690
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.690
1pk8 ATPSynapsin-1 / 0.689
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.689
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.689
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.689
4o0w ADNAurora kinase A 2.7.11.1 0.688
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.688
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.687
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.686
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.686
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.686
1ol6 ATPAurora kinase A 2.7.11.1 0.685
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.685
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.685
3pff ADPATP-citrate synthase 2.3.3.8 0.684
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.684
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.683
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.682
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
4ffm ADPUncharacterized protein / 0.682
4o1p ANPRibonuclease L / 0.681
5iqd GNPBifunctional AAC/APH 2.3.1 0.681
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.680
2pup ADPMethylthioribose kinase 2.7.1.100 0.679
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.679
4xlv ACPInsulin receptor 2.7.10.1 0.679
5iqg GDPBifunctional AAC/APH 2.3.1 0.679
4c3r ACPAurora kinase A 2.7.11.1 0.678
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.677
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.677
4bn1 ADPAurora kinase A 2.7.11.1 0.677
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.676
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.676
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.676
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
5eg3 ACPFibroblast growth factor receptor 2 / 0.676
2j9g ADPBiotin carboxylase 6.3.4.14 0.675
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.675
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.674
2wqe ADPAurora kinase A 2.7.11.1 0.674
2pul ACPMethylthioribose kinase 2.7.1.100 0.673
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.672
3c4w ATPRhodopsin kinase / 0.672
3oro AGSSerine/threonine protein kinase / 0.672
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.672
5dt4 ATPAurora kinase A 2.7.11.1 0.672
5iqe GNPBifunctional AAC/APH 2.3.1 0.672
5iqi GNPBifunctional AAC/APH 2.3.1 0.672
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
3iew CTP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.671
1ol7 ADPAurora kinase A 2.7.11.1 0.670
5ce3 ADPProtein kinase YopO / 0.670
2pun ACPMethylthioribose kinase 2.7.1.100 0.669
2pz5 ACPFibroblast growth factor receptor 2 / 0.669
3wo1 ADPAlanine--anticapsin ligase / 0.669
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.669
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.668
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.668
4o4e ATPKinase / 0.668
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.668
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.668
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.667
4o4f ATPKinase / 0.667
4u0o MTALipoyl synthase 2 / 0.667
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.665
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.665
2py3 ACPFibroblast growth factor receptor 2 / 0.663
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.663
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.663
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.662
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.661
1ir3 ANPInsulin receptor 2.7.10.1 0.660
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.660
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.660
4o0s ADNAurora kinase A 2.7.11.1 0.660
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.659
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.659
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.659
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.657
2yaa ATPDeath-associated protein kinase 2 / 0.657
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.657
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.657
1rfu ADPPyridoxal kinase 2.7.1.35 0.656
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.656
3ori AGSSerine/threonine protein kinase / 0.655
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.654
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.654
3nie ANPMitogen-activated protein kinase / 0.653
3orm AGSSerine/threonine protein kinase / 0.653
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.653
3rv4 ADPBiotin carboxylase 6.3.4.14 0.653
4kpu FADElectron transfer flavoprotein alpha/beta-subunit / 0.653
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.652
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4c8e C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.650