Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gvj ADP Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 1.015
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.870
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.866
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.864
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.855
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.849
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.849
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.848
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.847
1mq4 ADPAurora kinase A 2.7.11.1 0.839
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.838
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.837
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.832
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.832
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.831
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.830
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.826
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.823
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.823
4utd ACPAurora kinase A 2.7.11.1 0.821
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.820
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.819
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.816
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.813
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.805
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.803
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.802
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.798
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.796
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.793
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.791
5dn3 ATPAurora kinase A 2.7.11.1 0.791
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.788
4ceg ADPAurora kinase A 2.7.11.1 0.787
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.787
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.786
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.784
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.783
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.782
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.781
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.780
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.779
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.778
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.776
3cly ACPFibroblast growth factor receptor 2 / 0.776
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.775
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.775
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
2pyw ADPMethylthioribose kinase 2.7.1.100 0.772
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.771
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.769
5dt3 ATPAurora kinase A 2.7.11.1 0.769
4gyi ADPUncharacterized protein / 0.768
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.768
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.763
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.761
4ork GDPBifunctional AAC/APH 2.3.1 0.760
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.758
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.758
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.755
4qny ANPMitogen activated protein kinase, putative / 0.755
4dee ADPAurora kinase A 2.7.11.1 0.753
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.752
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.752
2olc ADPMethylthioribose kinase 2.7.1.100 0.750
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
4ysj ADPCalmodulin-like domain protein kinase / 0.749
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.747
2vqd AP2Biotin carboxylase 6.3.4.14 0.746
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.744
3bu5 ATPInsulin receptor 2.7.10.1 0.739
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
5iqb GNPBifunctional AAC/APH 2.3.1 0.739
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.736
5eg3 ACPFibroblast growth factor receptor 2 / 0.733
4fu0 ADPD-alanine--D-alanine ligase / 0.732
5ce3 ADPProtein kinase YopO / 0.732
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.731
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.731
5dr2 ATPAurora kinase A 2.7.11.1 0.729
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.728
2pui ADPMethylthioribose kinase 2.7.1.100 0.728
2pzp ACPFibroblast growth factor receptor 2 / 0.728
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.728
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.726
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.726
4xlv ACPInsulin receptor 2.7.10.1 0.726
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.725
5drd ATPAurora kinase A 2.7.11.1 0.724
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.723
2pml ANPUncharacterized protein / 0.723
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.723
5dnr ATPAurora kinase A 2.7.11.1 0.723
5dos ATPAurora kinase A 2.7.11.1 0.723
1m0w ANPGlutathione synthetase 6.3.2.3 0.721
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.720
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.718
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.717
2py3 ACPFibroblast growth factor receptor 2 / 0.716
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.716
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.714
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.714
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.713
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.713
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.712
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.711
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.710
1cm8 ANPMitogen-activated protein kinase 12 / 0.709
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.709
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.709
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.709
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.709
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.709
1ol7 ADPAurora kinase A 2.7.11.1 0.708
5iqh GNPBifunctional AAC/APH 2.3.1 0.707
1ol5 ADPAurora kinase A 2.7.11.1 0.706
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.706
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.705
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.705
4bn1 ADPAurora kinase A 2.7.11.1 0.703
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.703
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.702
3tdw GDPGentamicin resistance protein / 0.702
3wnz ADPAlanine--anticapsin ligase / 0.702
5ckw ANPUncharacterized protein / 0.702
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.701
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.701
4ffm ADPUncharacterized protein / 0.701
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.701
1ol6 ATPAurora kinase A 2.7.11.1 0.700
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.700
4o1p ANPRibonuclease L / 0.700
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.697
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.697
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.697
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.695
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.695
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.695
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.693
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4ix5 ANPUncharacterized protein / 0.693
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.691
1i44 ACPInsulin receptor 2.7.10.1 0.690
3c4z ADPRhodopsin kinase / 0.690
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
5iqa GNPBifunctional AAC/APH 2.3.1 0.690
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.689
5dt4 ATPAurora kinase A 2.7.11.1 0.689
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.688
4ffl ADPUncharacterized protein / 0.688
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.686
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.685
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.685
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.684
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.684
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.683
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.683
2pun ACPMethylthioribose kinase 2.7.1.100 0.682
2pup ADPMethylthioribose kinase 2.7.1.100 0.682
5iqd GNPBifunctional AAC/APH 2.3.1 0.682
5iqi GNPBifunctional AAC/APH 2.3.1 0.682
2dwb ANPAurora kinase A 2.7.11.1 0.681
3c50 ADPRhodopsin kinase / 0.681
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.681
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.681
1v8k ANPKinesin-like protein KIF2C / 0.680
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.680
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.680
2dwp ACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.679
2hgs ADPGlutathione synthetase 6.3.2.3 0.679
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.678
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.678
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.678
5iqe GNPBifunctional AAC/APH 2.3.1 0.678
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.677
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.677
3ori AGSSerine/threonine protein kinase / 0.677
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.677
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.677
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.676
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.676
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4zol ACPTubulin tyrosine ligase / 0.675
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.674
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.674
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.672
3tw6 ADPPyruvate carboxylase / 0.672
5byl GCPBifunctional AAC/APH 2.3.1 0.672
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.671
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.671
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.670
1u54 ACPActivated CDC42 kinase 1 / 0.670
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.670
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.670
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.669
2pvy ACPFibroblast growth factor receptor 2 / 0.669
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.668
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
3qc9 ADPRhodopsin kinase / 0.667
3wo0 ADPAlanine--anticapsin ligase / 0.667
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5iqf GDPBifunctional AAC/APH 2.3.1 0.667
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.666
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.666
4db1 ANPMyosin-7 / 0.666
5l8j ADPAurora kinase A 2.7.11.1 0.666
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.665
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.664
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4o4e ATPKinase / 0.664
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.663
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.663
1aq2 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.662
1px2 ATPSynapsin-1 / 0.662
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.662
3orm AGSSerine/threonine protein kinase / 0.662
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.662
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
4j95 ACPFibroblast growth factor receptor 2 / 0.662
4o4f ATPKinase / 0.662
3g8d ADPBiotin carboxylase 6.3.4.14 0.661
3sqw ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.661
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.661
2wqe ADPAurora kinase A 2.7.11.1 0.660
3myk ANPMyosin-2 heavy chain / 0.660
3t8o ATPRhodopsin kinase / 0.660
5l8k ADPAurora kinase A 2.7.11.1 0.660
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.659
4c3r ACPAurora kinase A 2.7.11.1 0.659
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.658
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.658
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
3wo1 ADPAlanine--anticapsin ligase / 0.658
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.658
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
4o0u ADNAurora kinase A 2.7.11.1 0.658
1ayl ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.657
3i5x ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.657
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.657
3zfd ANPChromosome-associated kinesin KIF4 / 0.657
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4ffr ATPUncharacterized protein / 0.657
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.656
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.656
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.656
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.655
3g8c ADPBiotin carboxylase 6.3.4.14 0.655
2cl6 CAGGTPase HRas / 0.654
2pz5 ACPFibroblast growth factor receptor 2 / 0.654
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.654
4bix ADPSensor histidine kinase CpxA / 0.654
1rfu ADPPyridoxal kinase 2.7.1.35 0.653
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.653
4q5h ANPProtein kinase OspG 2.7 0.653
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.652
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3ibq ATPPyridoxal kinase / 0.652
1ir3 ANPInsulin receptor 2.7.10.1 0.651
2yaa ATPDeath-associated protein kinase 2 / 0.651
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.651
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.650
4j98 ACPFibroblast growth factor receptor 2 / 0.650
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.650
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.650