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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dxh NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.358
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.348
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.321
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.320
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.309
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.297
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.291
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.269
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.246
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.243
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.210
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.197
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.194
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.190
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.171
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.110
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.096
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.951
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.946
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.931
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.928
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.926
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.926
1yqd NAPSinapyl alcohol dehydrogenase / 0.919
3jv7 NADSecondary alcohol dehydrogenase / 0.913
3wle NAD(R)-specific carbonyl reductase / 0.901
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.895
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.894
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.892
3two NDPMannitol dehydrogenase / 0.877
1yqx NAPSinapyl alcohol dehydrogenase / 0.871
4oaq NDPR-specific carbonyl reductase / 0.866
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.854
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.847
2xaa NADSecondary alcohol dehydrogenase / 0.842
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.836
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.835
4c4o NADSADH / 0.834
1uxj NADMalate dehydrogenase / 0.817
1u7h NADPutative ornithine cyclodeaminase / 0.814
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.812
4cpd NADAlcohol dehydrogenase / 0.810
1uxk NADMalate dehydrogenase / 0.809
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.809
1x7d NADPutative ornithine cyclodeaminase / 0.807
4rqu NADAlcohol dehydrogenase class-P / 0.807
1gv0 NADMalate dehydrogenase / 0.804
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.797
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.794
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.788
4l0q NADAlcohol dehydrogenase class-3 / 0.779
4ejm NAPPutative zinc-binding dehydrogenase / 0.778
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.776
4jji NADAlcohol dehydrogenase class-3 / 0.774
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.770
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.770
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.769
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.768
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.763
2dph NADFormaldehyde dismutase / 0.761
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.761
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.757
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.757
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.756
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.747
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.746
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.745
2vwh NAPGlucose 1-dehydrogenase / 0.745
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.744
3wsw NADL-lactate dehydrogenase / 0.743
4i1i NADMalate dehydrogenase / 0.739
4jk3 NADUncharacterized protein / 0.739
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.739
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.737
2o4c NADErythronate-4-phosphate dehydrogenase / 0.736
4j49 NADUncharacterized protein / 0.736
4plp NADHomospermidine synthase 2.5.1.44 0.735
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.733
1ur5 NADMalate dehydrogenase / 0.733
3abi NADUncharacterized protein / 0.733
4b7x NAPProbable oxidoreductase / 0.732
1pzh NADLactate dehydrogenase / 0.731
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.730
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.730
2vhx NADAlanine dehydrogenase 1.4.1.1 0.729
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.727
2voj NADAlanine dehydrogenase 1.4.1.1 0.724
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.723
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.722
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.722
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.721
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.720
2a92 NAIL-lactate dehydrogenase / 0.718
5a1t NAIL-lactate dehydrogenase / 0.718
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.717
4xq9 NADHomospermidine synthase 2.5.1.44 0.715
1llu NADAlcohol dehydrogenase / 0.714
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.713
1sow NADL-lactate dehydrogenase 1.1.1.27 0.712
3uko NADAlcohol dehydrogenase class-3 / 0.712
2ejv NADL-threonine 3-dehydrogenase / 0.709
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
4k28 NADShikimate dehydrogenase family protein / 0.702
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.701
4xrg NADHomospermidine synthase 2.5.1.44 0.700
4j43 NADUncharacterized protein / 0.699
1pjc NADAlanine dehydrogenase / 0.698
3wfj NAD2-dehydropantoate 2-reductase / 0.698
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.696
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.695
1ie3 NADMalate dehydrogenase / 0.693
1o6z NADMalate dehydrogenase / 0.693
1wze NADMalate dehydrogenase / 0.693
2x0i NAIMalate dehydrogenase / 0.693
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.692
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.691
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.691
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.691
1c1d NAIPhenylalanine dehydrogenase / 0.689
2dfv NADL-threonine 3-dehydrogenase / 0.689
3ikt NADRedox-sensing transcriptional repressor Rex / 0.689
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.689
4xqc NADHomospermidine synthase 2.5.1.44 0.689
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.687
4j49 NAIUncharacterized protein / 0.687
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.686
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.685
1pzf A3DLactate dehydrogenase / 0.684
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.684
2aa3 AP0L-lactate dehydrogenase / 0.683
2y05 NAPProstaglandin reductase 1 / 0.681
3ggo NAIPrephenate dehydrogenase / 0.681
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.680
3q2k NAIProbable oxidoreductase / 0.680
1b8u NADMalate dehydrogenase / 0.679
3kb6 NADD-lactate dehydrogenase / 0.679
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.678
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.678
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.677
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
2cda NAPGlucose 1-dehydrogenase / 0.676
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.675
2cdc NAPGlucose 1-dehydrogenase / 0.675
2uyy NA7Putative oxidoreductase GLYR1 1 0.674
3oet NADErythronate-4-phosphate dehydrogenase / 0.674
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.673
4y0k NAPAntE / 0.673
2x0r NADMalate dehydrogenase / 0.672
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.672
4tvb NADHomospermidine synthase 2.5.1.44 0.672
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.671
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.670
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.669
3wid NAPGlucose 1-dehydrogenase / 0.669
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.668
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.667
2v7g NADUrocanate hydratase 4.2.1.49 0.667
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.666
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.665
4yai NAIC alpha-dehydrogenase / 0.665
5bsg NAPPyrroline-5-carboxylate reductase / 0.665
2yvg NADFerredoxin reductase / 0.664
3x2f NAIAdenosylhomocysteinase / 0.664
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.663
2ome NADC-terminal-binding protein 2 / 0.663
3d64 NADAdenosylhomocysteinase / 0.663
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.663
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.662
4j4b NAIUncharacterized protein / 0.662
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.661
2b5v NAPGlucose 1-dehydrogenase / 0.659
2fkn NADUrocanate hydratase 4.2.1.49 0.659
3ggp NADPrephenate dehydrogenase / 0.659
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.658
1wzi NDPMalate dehydrogenase / 0.657
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.657
3f3s NADLambda-crystallin homolog / 0.657
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
1bw9 NADPhenylalanine dehydrogenase / 0.655
3keo NADRedox-sensing transcriptional repressor Rex / 0.655
5a02 NAPGlucose-fructose oxidoreductase / 0.655
5br7 FADUDP-galactopyranose mutase / 0.655
4weq NAPNAD-dependent dehydrogenase / 0.654
1bmd NADMalate dehydrogenase / 0.653
1ib6 NADMalate dehydrogenase / 0.652
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.652
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.652
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.652
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.651
2dbz NAPGlyoxylate reductase 1.1.1.26 0.651
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.651
2hu2 NADC-terminal binding protein 1 / 0.651
3ec7 NADInositol 2-dehydrogenase / 0.650
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650