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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4blt APC NTPase P4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4blt APCNTPase P4 / 0.793
1jsz NDMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2.1.1.57 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
1m8e H4BNitric oxide synthase, inducible 1.14.13.39 0.688
2b99 RDLRiboflavin synthase 2.5.1.9 0.688
2fr8 NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.688
3e67 H4BNitric oxide synthase, inducible 1.14.13.39 0.688
3ict ADPCoenzyme A disulfide reductase / 0.688
4ug7 H4BNitric oxide synthase oxygenase 1.14.13.165 0.688
4uga H4BNitric oxide synthase oxygenase 1.14.13.165 0.688
2opn SUFFarnesyl pyrophosphate synthase 2.5.1.10 0.669
1qom H4BNitric oxide synthase, inducible 1.14.13.39 0.665
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.665
2kwi GNPRas-related protein Ral-B / 0.665
2uyq SAMPutative S-adenosyl-L-methionine-dependent methyltransferase ML2640 2.1.1 0.665
2w1d L0DAurora kinase A 2.7.11.1 0.665
2x9n AX3Pteridine reductase / 0.665
3blo QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.665
4dta ADNAPH(2'')-Id / 0.665
1c3x 8IGPurine nucleoside phosphorylase 2.4.2.1 0.660
1i7c MGBS-adenosylmethionine decarboxylase proenzyme 4.1.1.50 0.660
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
1zot EMABifunctional hemolysin/adenylate cyclase 4.6.1.1 0.660
2ofi ADK3-methyladenine DNA glycosylase I / 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
5l6w AGSLIM domain kinase 1 2.7.11.1 0.657
1dwx H4BNitric oxide synthase, inducible 1.14.13.39 0.656
1m8h H4BNitric oxide synthase, inducible 1.14.13.39 0.656
1m8i H4BNitric oxide synthase, inducible 1.14.13.39 0.656
1m9k 7NINitric oxide synthase, endothelial 1.14.13.39 0.656
1m9t H4BNitric oxide synthase, inducible 1.14.13.39 0.656
1yda AZMCarbonic anhydrase 2 4.2.1.1 0.656
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
3b2t M33Fibroblast growth factor receptor 2 / 0.656
3bmn AX3Pteridine reductase / 0.656
3djf BC3Purine nucleoside phosphorylase / 0.656
3e6o H4BNitric oxide synthase, inducible 1.14.13.39 0.656
3usn ATTStromelysin-1 3.4.24.17 0.656
4dt8 ADNAPH(2'')-Id / 0.656
4dtb GMPAPH(2'')-Id / 0.656
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.656
4jik 1KOSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.656
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.656
1wpg ADPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.655
2wwj Y28Lysine-specific demethylase 4A / 0.651
3t2g 13PFructose-1,6-bisphosphate aldolase/phosphatase / 0.650
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.650