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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bls APC NTPase P4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bls APCNTPase P4 / 0.810
1xxj UNCUricase 1.7.3.3 0.744
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.744
3f8p NADNADH oxidase/thioredoxin reductase / 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
4e5l DBHPolymerase acidic protein / 0.744
1w48 APCNTPase P4 / 0.693
1gle ADPGlycerol kinase / 0.674
1jhr P2PNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2.4.2.21 0.671
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.671
1ftl DNQGlutamate receptor 2 / 0.670
1xz8 5GPBifunctional protein PyrR 2.4.2.9 0.670
2e9z UTPGenome polyprotein / 0.670
2ydb NAP2',3'-cyclic-nucleotide 3'-phosphodiesterase 3.1.4.37 0.670
3hz6 ADPXylulokinase / 0.670
3ms5 REEGamma-butyrobetaine dioxygenase 1.14.11.1 0.670
5htx ADPPutative xylulose kinase / 0.670
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1o51 ADPUPF0166 protein TM_0021 / 0.660
1ybu APCProbable lignin peroxidase LipJ / 0.660
2g6j 7APNitric oxide synthase, brain 1.14.13.39 0.660
2oem 1AE2,3-diketo-5-methylthiopentyl-1-phosphate enolase 5.3.2.5 0.660
2qf2 GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3beg ANPSRSF protein kinase 1 2.7.11.1 0.660
3lm9 ADPPutative fructokinase 2.7.1.4 0.660
3ppo DCKGlycine betaine/carnitine/choline-binding protein OpuCC / 0.660
4uga H4BNitric oxide synthase oxygenase 1.14.13.165 0.655
2yoz OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase 3.1.4.37 0.654
2e20 B4PPropionate kinase / 0.650