Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pup ADP Methylthioribose kinase 2.7.1.100

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pup ADPMethylthioribose kinase 2.7.1.100 1.011
2pui ADPMethylthioribose kinase 2.7.1.100 0.909
2pul ACPMethylthioribose kinase 2.7.1.100 0.881
2pun ACPMethylthioribose kinase 2.7.1.100 0.825
3c4z ADPRhodopsin kinase / 0.822
4ceg ADPAurora kinase A 2.7.11.1 0.821
2pyw ADPMethylthioribose kinase 2.7.1.100 0.814
1mq4 ADPAurora kinase A 2.7.11.1 0.811
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.790
4utd ACPAurora kinase A 2.7.11.1 0.788
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.782
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.780
3t8o ATPRhodopsin kinase / 0.773
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.771
5dos ATPAurora kinase A 2.7.11.1 0.771
3c50 ADPRhodopsin kinase / 0.769
4dee ADPAurora kinase A 2.7.11.1 0.769
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.768
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.768
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.767
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.766
2olc ADPMethylthioribose kinase 2.7.1.100 0.763
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.759
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.757
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.755
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.751
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.749
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.748
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.748
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.747
3ori AGSSerine/threonine protein kinase / 0.747
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.746
4n57 ADPAPH(2'')-Id / 0.746
5dn3 ATPAurora kinase A 2.7.11.1 0.746
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.743
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.742
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.741
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.741
3c4x ATPRhodopsin kinase / 0.738
5iqb GNPBifunctional AAC/APH 2.3.1 0.738
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
4gyi ADPUncharacterized protein / 0.734
5dr2 ATPAurora kinase A 2.7.11.1 0.734
3qc9 ADPRhodopsin kinase / 0.733
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.732
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.731
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.731
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.731
5dt3 ATPAurora kinase A 2.7.11.1 0.731
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.729
5dt4 ATPAurora kinase A 2.7.11.1 0.729
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.728
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.727
2pzp ACPFibroblast growth factor receptor 2 / 0.727
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.727
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.724
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.724
2pz5 ACPFibroblast growth factor receptor 2 / 0.722
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
3c4w ATPRhodopsin kinase / 0.720
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.720
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.719
5drd ATPAurora kinase A 2.7.11.1 0.719
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.718
4ork GDPBifunctional AAC/APH 2.3.1 0.718
2py3 ACPFibroblast growth factor receptor 2 / 0.715
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.714
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.714
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.713
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.712
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.712
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.712
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.711
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.711
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.711
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.711
3cly ACPFibroblast growth factor receptor 2 / 0.708
5dnr ATPAurora kinase A 2.7.11.1 0.708
3bu5 ATPInsulin receptor 2.7.10.1 0.707
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.706
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.705
5l8l ADPAurora kinase A 2.7.11.1 0.705
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.704
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.704
4c3r ACPAurora kinase A 2.7.11.1 0.704
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
5l8j ADPAurora kinase A 2.7.11.1 0.704
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.703
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.702
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.701
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.701
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.700
4zgn ATPCell division cycle protein 123 / 0.699
4o4d ATPKinase / 0.698
4qny ANPMitogen activated protein kinase, putative / 0.698
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.697
4bn1 ADPAurora kinase A 2.7.11.1 0.697
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.696
2x0q ATPAlcaligin biosynthesis protein / 0.696
4ysj ADPCalmodulin-like domain protein kinase / 0.696
5byl GCPBifunctional AAC/APH 2.3.1 0.696
4xlv ACPInsulin receptor 2.7.10.1 0.695
5iqf GDPBifunctional AAC/APH 2.3.1 0.694
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.693
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.692
3tdw GDPGentamicin resistance protein / 0.692
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.692
2j9g ADPBiotin carboxylase 6.3.4.14 0.691
3q5i ANPProtein kinase, putative / 0.691
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.690
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.688
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.687
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.687
1i44 ACPInsulin receptor 2.7.10.1 0.686
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.686
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.683
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.683
4o1p ANPRibonuclease L / 0.683
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.682
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.682
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
3g8d ADPBiotin carboxylase 6.3.4.14 0.681
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.681
2pml ANPUncharacterized protein / 0.680
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.680
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.679
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.678
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.678
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.678
4q5h ANPProtein kinase OspG 2.7 0.678
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.678
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.676
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.676
3orm AGSSerine/threonine protein kinase / 0.676
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
3tdv GDPGentamicin resistance protein / 0.676
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.676
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.675
3pff ADPATP-citrate synthase 2.3.3.8 0.675
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.675
1ol6 ATPAurora kinase A 2.7.11.1 0.674
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.674
5iqd GNPBifunctional AAC/APH 2.3.1 0.674
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.673
5iqe GNPBifunctional AAC/APH 2.3.1 0.673
5l8k ADPAurora kinase A 2.7.11.1 0.673
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.672
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.672
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.671
3hyo ADPPyridoxal kinase / 0.670
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.669
1u54 ACPActivated CDC42 kinase 1 / 0.668
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.668
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.667
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.666
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
3nie ANPMitogen-activated protein kinase / 0.665
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.665
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.664
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.664
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.664
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.663
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.663
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.663
5eg3 ACPFibroblast growth factor receptor 2 / 0.663
5iqh GNPBifunctional AAC/APH 2.3.1 0.663
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.662
4dt8 ADNAPH(2'')-Id / 0.662
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.661
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.661
1ol5 ADPAurora kinase A 2.7.11.1 0.660
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.660
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
5iqa GNPBifunctional AAC/APH 2.3.1 0.660
2dwb ANPAurora kinase A 2.7.11.1 0.659
2fsn ADPArchaeal actin homolog / 0.659
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.658
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.658
1m0w ANPGlutathione synthetase 6.3.2.3 0.657
4ix5 ANPUncharacterized protein / 0.657
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.657
2p0a ANPSynapsin-3 / 0.656
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.656
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.656
4e32 DWNMethyltransferase / 0.656
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.656
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.656
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.655
1vc9 ATPDiadenosine hexaphosphate hydrolase 3.6.1.61 0.655
1z6t ADPApoptotic protease-activating factor 1 / 0.655
3r5f ATPD-alanine--D-alanine ligase / 0.655
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.655
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.654
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.654
3m0e ATPTranscriptional regulator (NtrC family) / 0.654
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.654
3a8w ATPProtein kinase C iota type 2.7.11.13 0.653
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1pk8 ATPSynapsin-1 / 0.652
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.652
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.652
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.652
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.651
4b8l A0PAurora kinase B-A 2.7.11.1 0.651
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.651
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.651
2cl6 CAGGTPase HRas / 0.650
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.650
3orp AGSSerine/threonine protein kinase / 0.650
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.650
4f0f ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.650