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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pun ACP Methylthioribose kinase 2.7.1.100

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pun ACPMethylthioribose kinase 2.7.1.100 1.015
2pul ACPMethylthioribose kinase 2.7.1.100 0.969
2olc ADPMethylthioribose kinase 2.7.1.100 0.869
2pui ADPMethylthioribose kinase 2.7.1.100 0.866
2pup ADPMethylthioribose kinase 2.7.1.100 0.825
3t8o ATPRhodopsin kinase / 0.812
2pyw ADPMethylthioribose kinase 2.7.1.100 0.797
2pz5 ACPFibroblast growth factor receptor 2 / 0.791
3c4w ATPRhodopsin kinase / 0.789
3c4z ADPRhodopsin kinase / 0.788
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.786
3c50 ADPRhodopsin kinase / 0.784
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.781
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.779
4dee ADPAurora kinase A 2.7.11.1 0.777
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.769
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.766
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.763
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.757
2py3 ACPFibroblast growth factor receptor 2 / 0.755
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.752
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
4o4d ATPKinase / 0.750
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.747
4xlv ACPInsulin receptor 2.7.10.1 0.747
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.745
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.745
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.744
3qc9 ADPRhodopsin kinase / 0.744
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.743
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.736
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.736
3c4x ATPRhodopsin kinase / 0.735
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.734
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.731
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.731
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.730
5dn3 ATPAurora kinase A 2.7.11.1 0.730
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.729
5dr2 ATPAurora kinase A 2.7.11.1 0.728
4ceg ADPAurora kinase A 2.7.11.1 0.727
4qny ANPMitogen activated protein kinase, putative / 0.727
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.726
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.726
3bu5 ATPInsulin receptor 2.7.10.1 0.725
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.721
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.720
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.719
2pzp ACPFibroblast growth factor receptor 2 / 0.719
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.718
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.718
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.717
3cly ACPFibroblast growth factor receptor 2 / 0.717
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.717
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.717
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.715
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.715
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.715
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.715
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.714
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.713
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.712
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.711
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.710
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.709
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.709
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.708
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.707
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.707
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.706
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.705
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.704
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.703
4q5h ANPProtein kinase OspG 2.7 0.703
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.701
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.700
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.699
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.698
5eg3 ACPFibroblast growth factor receptor 2 / 0.698
1ol6 ATPAurora kinase A 2.7.11.1 0.697
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.697
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.697
1cm8 ANPMitogen-activated protein kinase 12 / 0.696
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.696
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.695
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.695
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.695
5dnr ATPAurora kinase A 2.7.11.1 0.695
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.692
2dwb ANPAurora kinase A 2.7.11.1 0.692
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.692
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.691
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.691
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.691
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.691
1mq4 ADPAurora kinase A 2.7.11.1 0.690
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.690
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.690
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.689
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.688
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.688
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.687
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.687
4gyi ADPUncharacterized protein / 0.687
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.687
3ibq ATPPyridoxal kinase / 0.686
4ork GDPBifunctional AAC/APH 2.3.1 0.686
4utd ACPAurora kinase A 2.7.11.1 0.686
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.685
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.683
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.683
1ol5 ADPAurora kinase A 2.7.11.1 0.682
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.682
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.682
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
5dos ATPAurora kinase A 2.7.11.1 0.681
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.680
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.680
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.679
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.679
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.678
1u54 ACPActivated CDC42 kinase 1 / 0.678
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
2vqd AP2Biotin carboxylase 6.3.4.14 0.677
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.677
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.676
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.676
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3llt ANPProtein serine/threonine kinase-1 / 0.675
4n57 ADPAPH(2'')-Id / 0.675
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.674
2zdg ADPD-alanine--D-alanine ligase / 0.674
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5dt4 ATPAurora kinase A 2.7.11.1 0.674
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.673
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.672
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.671
4bn1 ADPAurora kinase A 2.7.11.1 0.671
4ffr ATPUncharacterized protein / 0.671
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.669
3q5i ANPProtein kinase, putative / 0.669
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.668
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.668
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.666
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.666
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.666
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.665
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.665
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
5l8j ADPAurora kinase A 2.7.11.1 0.664
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.663
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.663
2j9g ADPBiotin carboxylase 6.3.4.14 0.662
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.662
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.662
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.661
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.661
4ffm ADPUncharacterized protein / 0.661
5dt3 ATPAurora kinase A 2.7.11.1 0.661
2pml ANPUncharacterized protein / 0.660
5l8l ADPAurora kinase A 2.7.11.1 0.660
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.659
1m0w ANPGlutathione synthetase 6.3.2.3 0.658
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.658
4c3p ACPAurora kinase A 2.7.11.1 0.658
3rv4 ADPBiotin carboxylase 6.3.4.14 0.657
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.657
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2pbz ATPUncharacterized protein / 0.656
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
1i44 ACPInsulin receptor 2.7.10.1 0.655
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.655
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.655
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
4ffl ADPUncharacterized protein / 0.654
4jrn ANPRhoptry kinase family protein / 0.654
4db1 ANPMyosin-7 / 0.653
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.653
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.652
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.652
1ol7 ADPAurora kinase A 2.7.11.1 0.652
1z6t ADPApoptotic protease-activating factor 1 / 0.652
4fu0 ADPD-alanine--D-alanine ligase / 0.652
5byl GCPBifunctional AAC/APH 2.3.1 0.652
5iqa GNPBifunctional AAC/APH 2.3.1 0.652
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.651
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.651
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.651
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.651
4idp GNPAtlastin-1 3.6.5 0.651
4dt8 ADNAPH(2'')-Id / 0.650
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.650